Ongoing Projects

  • Development of high-resolution ultra-deep pan-proteomic profiling of primary human tumors by mass spectrometry
  • Integrated proteogenomic “big data” analyses of tumors using WGS/WES, RNA-Seq, and LC-MS datasets
  • Characterization of phosphoproteomic tumor signaling adaptation under targeted therapies (response vs. resistance)
  • Highly multiplexed quantitative protein biomarker assessment in clinical trials using LC-MS/MS
  • Elucidating the “antigen-ome” of autoreactive immunogenic tumor neoantigens in solid tumors