I am a clinician-scientist with experience in the application of a wide range of molecular imaging tools in both preclinical and clinical settings. At Memorial Sloan Kettering, I direct a laboratory that focuses on the development, characterization, and evaluation of translational silica nanomaterials for cancer applications. We use these materials in conjunction with imaging tools (including PET and optical devices) to individualize patient care. In addition, my team explores the biological and chemical interactions of these materials at multiple spatial scales — from the cellular/molecular level to that of organs and tissues. We then link these findings to sites of disease using whole-body imaging studies of small animal models and humans.
Michelle S. Bradbury, MD, PhD
Director of Intraoperative Imaging, Radiology
Research FocusClinician-scientist Michelle Bradbury develops translational, tumor-targeting, PET-optical silica nanoparticle probes for diagnostics, drug delivery, and sensing.
- Suteewong T, Sai H, Hovden R, Muller D, Bradbury MS, Gruner S, Wiesner U. Multicompartment Mesoporous Silica Nanoparticles with Branched Shapes: An Epitaxial Growth Mechanism. Science 340: 337–341, 2013.
- Phillips E, Penate-Medina O, Zanzonico PB, Carvajal RD, Mohan P, Ye Y, Humm J, Gönen M, Kalaigian H, Schöder H, Strauss HW, Larson SM, Wiesner U, Bradbury MS.Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe. Sci Transl Med. 2014 Oct 29;6(260):260ra149. doi: 10.1126/scitranslmed.3009524. Epub 2014 Oct 29. Abstract | Reprint | Full Text