Design of Novel SERS and SERRS Nanoparticles
We are currently developing and testing novel surface-enhanced Raman spectroscopy (SERS) and surface-enhanced resonant Raman spectroscopy (SERRS) nanoparticles. The goal is to further optimize individual factors contributing to the Raman signal enhancement (e.g., particle geometry, Raman dye chemistry) as well as to optimize biodistribution and tumor-targeting properties via rational surface modification.
Pre- and Intraoperative Brain Tumor Imaging with Raman-MRI-Photoacoustic Triple-Modality Nanoparticles
Validation of a recently developed multimodal molecular brain tumor imaging strategy is currently under way. In collaboration with the Holland lab we are testing multimodal nanoparticles in a mouse glioma model (RCAS/tv-a), which closely replicates the human glioblastoma growth pattern.
Pre- and Intraoperative Detection of Metastases with Multimodal SERRS Nanoparticles
We are developing and testing novel multimodal SERRS nanoparticles for combined pre- and intraoperative in vivo visualization of primary tumor and metastases.
In Vivo Tumor Profiling
The goal of this project is to develop a Raman-based strategy to perform in vivo tumor profiling.
Skin Cancer Detection with Raman Nanoprobes
The aim of this project aims is to develop an imaging method to be used as an alternative to skin lesion biopsies. This involves development of Raman-detectable skin-penetrating and cancer-targeted nanoprobes.