Projects

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DNA damage repair in prostate cancer

Understanding the impact of DNA damage repair (DDR) abnormalities in prostate cancer progression. 

Genetic Epidemiology of prostate cancer

Understanding the roles of germline variations in antioxidant, hormone signaling, and hormone transporters in prostate cancer development and progression.

Resistance Mechanisms to hormonal and chemotherapy

Understanding mechanisms of resistance to androgen deprivation therapy, enzalutamide, abiraterone, docetaxel and PARP inhibitors.

Non-Coding RNAs and their role in prostate cancer

Understanding the role of non-coding RNAs (including miRNAs, LncRNAs, and NC sponge mechanism) in prostate cancer development and progression.

Androgen Transporters

Understanding how androgen transporters (SLCO family) participate in progression of prostate cancer and resistance mechanisms.

Studies of the Y chromosome

Investigating the effect of Y-chromosome loss in castration-resistant prostate cancer (CRPC) progression. 

Transcription factors and aggressive prostate cancer

Understanding the role of transcription factors in aggressive prostate cancer. 

Cholesterol metabolism in prostate cancer

Understanding the role of cholesterol metabolism in progression of Localized prostate cancer to a lethal disease