Research into the immunobiology of allogeneic hematopoietic cell transplantation and adoptive cell therapies may be instrumental in developing effective cancer treatments. Our laboratory’s program of research has as its goal the elucidation and therapeutic exploitation of the biology of cell-based adoptive immunotherapies used in conjunction with allogeneic hematopoietic cell transplants. These transplants are designed to confer enhanced tumor resistance to patients transplanted for hematopoietic malignancies and to promote reconstitution of immunity to viral pathogens in the post transplant period.
Richard J. O'Reilly, MD
Research FocusPhysician-scientist Richard O’Reilly investigates the genetic disparities and cellular interactions between donor and host that affect allogeneic hematopoietic cell transplantation.
- MD, University of Rochester School of Medicine
- Koehne G, Gallardo H, Sadelain M, O’Reilly RJ. Rapid selection of antigen-specific T-lymphocytes by retroviral transduction. Blood, 96:109-117, 2000.
- Koehne G, Smith KM, Dupont B, O’Reilly RJ. Quantitation, selection and functional characterization of EBV-specific and alloreactive T cells detected by intracellular interferon-g production and growth of cytotoxic precursors. Blood, 99:1730-1740, 2002.