My research program has focused on 2 areas of cell biology: the molecular mechanisms of mammalian cell differentiation and mitotic checkpoint control. Though seemingly unrelated, both areas as described below continue to provide fertile ground for the analysis of molecular mechanisms and direct application to cancer biology. In the most general terms, we are exploring the role of the Id proteins in controlling the growth and differentiation of tumor cells and the vasculature that supports their growth. In addition, we are examining the role of the mitotic checkpoint gene Mad2 in maintaining genome stability by ensuring proper chromosome segregation during mitosis.
Robert Benezra, PhD
Research FocusCancer biologist Robert Benezra studies the molecular mechanisms of tumor growth and progression using mouse Id1 and Id3 knockout models and analysis of the spindle assembly checkpoint.
- PhD, Columbia University
- Sotillo, R., Hernando, E., Diaz-Rodriguez, E., Teruya-Feldstein, J., Cordon-Cardo, C., Lowe, S.W. and Benezra, R. (2007). Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11:9-23.
- Jankovic, V., Ciarrocchi, A., Boccuni, P., Deblasio, T., Benezra, R. and Nimer, S (2007) Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells. PNAS 104: 1260-1265.