Sam S. Yoon: Publications


Poteat HT, Ramstedt U, Yoon S, Dardik M, Terwilliger E, Sodroski JG.  Cyclic AMP-mediated growth arrest is associated with increased expression of human T cell leukemia virus type I structural and transforming genes.  AIDS Research & Human Retroviruses 12(6):527-533, Apr. 10. 1996.

Choi SH, Takahashi K, Eto H, Yoon SS, Tanabe KK.  CD44H alternative splicing in colon carcinomas influences metastatic potential.  Surgical Forum 49:402-3, 1998.

Yoon SS, Carroll NM, Chiocca EA, Tanabe KK.  Cancer gene therapy using a replication- competent herpes simplex virus type 1 vector.  Annals of Surgery 228(3):366-374, Sept. 1998.

Yoon SS, Eto H, Tanabe KK.  Gene transfer of mouse endostatin into colon carcinoma cells inhibits endothelial cell proliferation, tumor growth, and liver metastasis.  Surgical Forum 50:402-3, 1999

Yoon SS, Carroll NM, Chiocca EA, Tanabe KK.  Influence of p53 on herpes simplex virus type 1 vectors for cancer gene therapy.  Journal of Gastrointestinal Surgery 3(1):34-48, Jan./Feb. 1999.

Yoon SS, Eto H, Lin CM, Nakamura H, Pawlik TM, Song SU, Tanabe KK.  Mouse endostatin inhibits the formation of lung and liver metastases.  Cancer Research 59(24):6251-6256, Dec. 15, 1999.

Nakamura H, Yoon SS, Pawlik TM, Mullen JT, Chandrasekhar S, Chiocca EA, Chung RY, Tanabe KK.  Mechanism of specific infection and destruction of diffuse liver metastases by a replication-competent herpes simplex virus.  Surgical Forum 51:284-6, 2000.

Yoon SS, Nakamura H, Carroll NM, Bode BP, Chiocca EA, Tanabe KK.  An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma.  FASEB Journal 14(2):301-311, Feb. 2000.

Choi SH, Takahashi K, Eto H, Yoon SS, Tanabe KK.  CD44s expression in human colon carcinomas influences growth of liver metastases.  International Journal of Cancer 85(4):523-526, Feb. 15, 2000.

Pawlik TM, Nakamura H, Yoon SS, Mullen JT, Chandrasekhar S, Chiocca EA, Tanabe KK.  Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpes virus.  Cancer Research 60(11):2790-2795, June 1, 2000.

Eto H, Yoon SS, Bode BP, Kamidono S, Makino K, Saya H, Nakamura H, Tanabe KK.  Mapping and regulation of the tumor-associated epitope recognized by monoclonal antibody RS-11.  Journal of Biological Chemistry 275(35):27075-27083, Sept. 1, 2000.

Nakamura H, Mullen JT, Chandrasekhar S, Pawlik TM, Yoon SS, Tanabe KK.  Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil.  Cancer Research 61(14):5447-5452, July 15, 2001.

Nakamura H, Kasuya H, Mullen JT, Yoon SS, Pawlik TM, Chandrasekhar S, Donahue JM, Chiocca EA, Chung RY, Tanabe KK.  Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5.  Journal of Clinical Investigation 109(7):871-882, Apr. 2002.

Pawlik TM, Nakamura H, Mullen JT, Kasuya H, Yoon SS, Chandrasekhar S, Chiocca EA, Tanabe KK.  Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.  Cancer 95(5):1171-1181, Sept. 1, 2002.

Mullen JT, Kasuya H, Yoon SS, Carroll NM, Pawlik TM, Chandrasekhar S, Nakamura H, Donahue JM, Tanabe KK.  Regulation of herpes simplex virus 1 replication using tumor-associated promoters.  Annals of Surgery 236(4):502-513, Oct. 2002.

Yoon SS, Charny CK, Fong Y, Jarnagin WR, Schwartz LH, Blumgart LH, DeMatteo RP.  Diagnosis, management, and outcomes of 115 patients with hepatic hemangioma.  Journal of the American College of Surgeons 197(3):392-402, Sept. 2003.

Yoon SS, Jarnagin WR, Fong Y, DeMatteo RP, Barakat RR, Blumgart LH, Chi DS.  Resection of recurrent ovarian or fallopian tube carcinoma involving the liver.  Gynecologic Oncology 91(2):383-388, Nov. 2003.

Yoon SS, Segal NH, Olshen AB, Brennan MF, Singer S.  Circulating angiogenic factor levels correlate with extent of disease and risk of recurrence in patients with soft tissue sarcoma.  Annals of Oncology 15(8):1261-1266, Aug. 2004.

Mullen JT, Donahue JM, Chandrasekhar S, Yoon SS, Liu W, Ellis LM, Nakamura H, Kasuya H, Pawlik TM, Tanabe KK.  Oncolysis by viral replication and inhibition of angiogenesis by a replication-conditional herpes simplex virus that expresses mouse endostatin.  Cancer 101(4):869-877, Aug. 15, 2004.

Yoon SS, Tanabe KK, Warshaw AL.  Adult primary retroperitoneal teratoma.  Surgery 137(6):663-664, June 2005.

Detwiller KY, Fernando NT, Segal NH, Ryeom SW, D’Amore PA, Yoon SS.  Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A.  Cancer Research 65(13):5881-5889, July 1, 2005.

Yoon SS, Kim SH, Gonen M, Heffernan NM, Detwiller KY, Jarnagin WR, D’Angelica M, Blumgart LH, Tanabe KK, Dematteo RP.  Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases.  Annals of Surgical Oncology 13(3):353-362, Mar. 2006.

Stipa F, Yoon SS, Liau KH, Fong Y, Jarnagin WR, D’Angelica M, Abou-Alfa G, Blumgart LH, DeMatteo RP.  Outcome of patients with fibrolamellar hepatocellular carcinoma.  Cancer 106(6):1331-1338, Mar. 15, 2006.

Yoon SS, Segal NH, Park PJ, Detwiller KY, Fernando NT, Ryeom SW, Brennan MF, Singer S.  Angiogenic profile of soft tissue sarcomas based on analysis of circulating factors and microarray gene expression.  Journal of Surgical Research 135(2):282-290, Oct. 2006.

Delaney TF, Kepka L, Goldberg SI, Hornicek FJ, Gebhardt MC, Yoon SS, Springfield DS, Raskin KA, Harmon DC, Kirsch DG, Mankin HJ, Rosenberg AE, Nielsen GP, Suit HD.  Radiation therapy for control of soft-tissue sarcomas resected with positive margins.  Inter-national Journal of Radiation Oncology, Biology, Physics 67(5):1460-1469, Apr. 1, 2007.

Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, Desphpande V, Suit HD, DeLaney TF, Yoon SS.  Treatment and outcome of 82 patients with angiosarcoma.  Annals of Surgical Oncology 14(6):1953-1967, June 2007.

Kaurah P, MacMillan A, Boyd N, Senz J, De Luca A, Chun N, Suriano G, Zaor S, Van Manen L, Gilpin C, Nikkel S, Connolly-Wilson M, Weissman S, Rubinstein WS, Sebold C, Greenstein R, Stroop J, Yim D, Panzini B, McKinnon W, Greenblatt M, Wirtzfeld D, Fontaine D, Coit D, Yoon S, Chung D, Lauwers G, Pizzuti A, Vaccaro C, Redal MA, Oliveira C, Tischkowitz M, Olschwang S, Gallinger S, Lynch H, Green J, Ford J, Pharoah P, Fernandez B, Huntsman D.  Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer.  Journal of the American Medical Association 297(21):2360-2372, June 6, 2007.

Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T.  A spatially and temporally restricted mouse model of soft tissue sarcoma.  Nature Medicine 13(8):992-997, Aug. 2007.

Gollogly LK, Ryeom SW, Yoon SS.  Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis.  Journal of Surgical Research 142(1):129-136, Sept. 2007.

Fernando NT, Koch M, Rothrock C, Gollogly LK, D’Amore PA, Ryeom S, Yoon SS.  Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors.  Clinical Cancer Research 14(5):1529-1539, Mar. 1, 2008.

Ryeom S, Baek KH, Rioth MJ, Lynch RC, Zaslavsky A, Birsner A, Yoon SS, McKeon F.  Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth.  Cancer Cell 13(5):420-431, May 2008.

Kirkham JC, Nero CJ, Tambouret RH, Yoon SS.  Leiomyoma and leiomyosarcoma arising from the round ligament of the uterus.  Journal of the American College of Surgeons 207(3):452, Sept. 2008.

Wagner TD, Kobayashi W, Dean S, Goldberg SI, Kirsch DG, Suit HD, Hornicek FJ, Pedlow FX, Raskin KA, Springfield DS, Yoon SS, Gebhardt MC, Mankin HJ, Delaney TF.  Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the bone.  International Journal of Radiation Oncology, Biology, Physics 73(1):259-266, Jan. 1, 2009.

Maduekwe UN, Hornicek, FJ, Springfield DS, Raskin, KA, Harmon DC, Choy E, Rosenberg AE, Nielsen GP, DeLaney TF, Chen YL, Ott MJ, Yoon SS.  Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas.  Annals of Surgical Oncology 16(5):1356-1363, May 2009

Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, Sindhwani V, Blaszkowsky LS, Yoon SS, Lahdenranta J, Bhargava P, Meyerhardt J, Clark JW, Kwak EL, Hezel AF, Miksad R, Abrams TA, Enzinger PC, Fuchs CS, Ryan DP, Jain RK.  Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: A phase II study.  Journal of Clinical Oncology 27(18):3027-3035, June 20, 2009.

Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch W, Park IH, Yoon SS, Minami T, Reeves R, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S. Down syndrome: protection against tumor growth and the role of the calcineurin inhibitor DSCR1. Nature 459(7250):1126-1130, June 25, 2009.

Schwab J, Antonescu C, Boland P, Healey J, Rosenberg A, Nielsen P, Iafrate J, Delaney T, Yoon S, Choy E, Harmon D, Raskin K, Yang C, Mankin H, Springfield D, Hornicek F, Duan Z. Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma.  Anticancer Research 29(6):1867-1871, June 2009.

DeLaney TF, Liebsch NJ, Pedlow FX, Adams J, Dean S, Yeap BY, McManus P, Rosenberg AE, Nielsen GP, Harmon DC, Spiro IJ, Raskin KA, Suit HD, Yoon SS, Hornicek FJ.  Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas.  International Journal of Radiation Oncology, Biology, Physics 74(3):732-739, July 1, 2009.

Yoon SS, Stangenberg L, Lee YL, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR,  Nielsen GP, Weissleder R, Mahmood U, Park PJ,  Jacks T, Dodd RD, Fisher CJ, Ryeom S, Kirsch DG.  Efficacy of sunitinib and radiation therapy in a genetically engineered mouse model of soft tissue sarcoma.  International Journal of Radiation Oncology, Biology, Physics 74(4):1207-1216, July 15, 2009.

Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, Stangenberg L, Eward WC, Hornicek FJ, Yoon SS, Brigman BE, Jacks T, Lev D, Mukherjee S, Kirsch DG. Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.  PLoS One 4(11):e8075, Nov 30, 2009.

Lee YJ, Koch M, Karl D, Torres-Collado AX, Fernando NT, Rothrock C, Kuruppu D, Ryeom S, Iruela-Arispe ML, Yoon SS. Variable efficacy of thrombospondin 1 against liver and lung metastases due to differential activity of ADAMTS1.  Cancer Research 70(3):948-56, Feb 1, 2010.

Maduekwe UN., Lauwers GY, Fernandez-del-Castillo C, Berger DL, Ferguson CM, Rattner DW, Yoon SS. A new metastatic lymph node ratio system reduces stage migration in patients undergoing D1 lymphadenectomy for gastric adenocarcinoma.  Annals of Surgical Oncology 17(5):1267-77, May 2010.

Yoon SS, Chen YL, Kirsch DG, Maduekwe U, Rosenberg AE, Nielsen GP, Sahani DS, Choy E, Harmon DC, DeLaney TF. Proton beam, intensity modulated, and/or intra-operative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas.  Annals of Surgical Oncology 17(6):1515-29, June 2010.

Kim B, Chen YL, Kirsch DG, Goldberg SI, Kobayashi W, Kung JH, Wolfgang JA, Doppke K, Rosenberg AE, Nielsen GP, Raskin KA, Springfield DS, Schwab JH, Gebhardt MC, Yoon SS, Hornicek FJ, DeLaney TF. An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control. International Journal of Radiation Oncology, Biology, Physics 77(3):843-50, Jul 1, 2010.

Zaslavsky A , Chen C, Ms. Jenny Grillo J, Baek KH, Holmgren L, Yoon SS, Folkman J, Ryeom S. Regional control of tumor growth.  Molecular Cancer Research 8(9):1186-206, Sep 2010.

Lin KY, Bagley AF, Zhang A, Karl DL, Yoon SS, Bhatia SN. Gold nanorod photothermal therapy in a genetically engineered mouse model of soft tissue sarcoma. Nano LIFE 1(3-4):277-87, Sep-Dec, 2010.

Lee YJ, Karl DL, Maduekwe UN, Rothrock C, Ryeom S, D’Amore PA, Yoon SS. Differential effects of VEGFR-1 and VEGFR-2 inhibition on tumor metastases based on host organ environment Cancer Research 70(21):8357-67, Nov 1, 2010.

Tejwani A, Kobayashi W, Chen YL, Rosenberg AE, Yoon S, Raskin KA, Rosenthal DI, Nielsen GP, Hornicek FJ, Delaney TF. Management of acral myxoinflammatory fibroblastic sarcoma. Cancer 116(24):5733-9, Dec 15, 2010.

Pandalai PK, Lauwers GY ,Chung DC, Patel D, Yoon SS. Prophylactic total gastrectomy for individuals with germline CDH1 mutation.  Surgery 149(3):347-55, Mar 2011.

Devisetty K, Kobayashi W, Suit HD, Goldberg SI, Niemierko A, Chen YL, Raskin KA, Schwab JH, Springfield DS, Yoon SS, Hornicek FJ, Delaney TF. Low-dose neoadjuvant external beam radiation therapy for soft tissue sarcoma.  International Journal of Radiation Oncology, Biology, Physics 80(3):779-86, Jul 1, 2011.

Yoon SS, Duda DG, Karl DL, Kim TM, Kambadakone AR, Chen YL, Rothrock C, Rosenberg AE, Nielsen GP, Kirsch DG, Choy E, Harmon DC, Hornicek FJ, Dreyfuss J, Ancukiewicz M,  Sahani DV, Park PJ, Jain RK, DeLaney TF. *Phase II study of neoadjuvant bevacizumab and radiation therapy for resectable soft tissue sarcomas.  International Journal of Radiation Oncology, Biology, Physics 81(4):1081-90, Nov 15, 2011. *Article featured on journal cover.

Wang J, Dang P, Raut CP, Pandalai PK, Maduekwe UN, Rattner DW, Lauwers GY, Yoon SS. Comparison of the 7th edition of the AJCC/UICC staging system for gastric cancer to a new staging system based on lymph node ratio: an analysis of 18,042 patients from the SEER database. Annals of Surgery 255(3):478-85, Mar 2012.

Lee YJ, Lee HJ, Choi SH, Jin YB, An HJ, Kang JH, Yoon SS, Lee YS. Soluble HSPB1 regulates VEGF-mediated angiogenesis through their direct interaction. Angiogenesis (in press).

Fujita H, Deshpande V, Lennerz J, Chung D, Patel D, Yoon SS, Lauwers GY. Endoscopic surveillance of patients with hereditary diffuse gastric cancer: biopsy recommendations following topographic distribution of cancer foci in a series of 10 CDH1-mutated gastrectomies. American Journal of Surgical Pathology (in press).

Wo JY, Yoon SS, Guimaraes AR, Wolfgang J, Mamon HJ, Hong TS. Gastric lymph node contouring atlas: a tool to aid in clinical target volume definition in 3D treatment planning for gastric cancer. Practical Radiation Oncology (in press).

Yoon SS. Chen YL, Kambadakone A, Schmidt B, DeLaney TF. Placement of biological mesh spacers prior to external beam radiation for retroperitoneal and pelvic tumors. Practical Radiation Oncology (in press).

Yeo-Jung Kim YJ, Lee HJ, Zhang AY, Schmidt B, Kim TM, E, Eisinger-Mathason, TSK, Karl DL, Nakazawa MS, Park PJ, Simon MC, Yoon SS. Overcoming evasive resistance from vascular endothelial growth factor A inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia inducible factor 1. International Journal of Cancer (in press).