Our main research goal is to understand the development of highly-specific neuronal circuits in the mammalian neocortex. Proper formation of neuronal circuit critically depends on the production, positioning, and differentiation of various types of neurons, which largely occur during early developmental stages. We thus hypothesize that neuronal circuit development is tightly linked to the early developmental processes of neurogenesis, neuronal migration and differentiation. To test this, a major focus of our research program is to bridge the gap between early development of the embryonic and neonatal neocortex and the emergence of highly-specific neuronal circuits in the postnatal neocortex. Specifically, we are working on the following two areas using rodents as a model with a combination of approaches including electrophysiology, two-photon/confocal laser scanning microscopy, mouse genetics/in utero manipulation.
Songhai Shi, PhD
Research FocusDevelopmental neurobiologist Songhai Shi investigates the molecular and cellular mechanisms underlying mammalian neuronal development and circuit formation.
- PhD, SUNY Stony Brook
- Yu, Y.-C., Bultje, R.S., Wang X., and Shi, S.-H. (2009) Specific synapses develop preferentially among sister excitatory neurons in the neocortex. Nature 458: 501-504.
- Bultje, R.S., Castaneda-Castellanos, D.R., Jan, L.Y., Jan, Y.N., Kriegstein, A.R., and Shi, S.-H. (2009) Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron 63: 189-202.