Our laboratory uses a combination of structural and functional approaches to elucidate the mechanisms of eukaryotic ion channels and membrane-embedded enzymes. The proteins that we study have important biological roles and are implicated in diseases including cardiac arrhythmia, immune disorders, and cancer.
- Veronica K. Dickson, Leanne Pedi, Stephen B. Long. Structure and insights into the function of a Ca2+-activated Cl− channel. Nature. doi:10.1038/nature13913. Published online 22 October 2014. (Abstract | Atomic Coordinates)
- Melinda M. Diver and Stephen B. Long. Mutational Analysis of the Integral Membrane Methyltransferase ICMT Reveals Potential Substrate Binding Sites. J Biol Chem. 2014. Sep 19;289(38):26007-20. Epub 2014 Jul 24 (Abstract)