My laboratory’s primary expertise is in molecular imaging, targeted radio diagnosis, and therapy using small molecules and monoclonal antibodies.
Currently, I am corresponding primary investigator of Memorial Sloan Ketterings’s In Vivo Cellular and Molecular Imaging Center (ICMIC) and coleader, with Ingo Mellinghoff and Charles Sawyers, of Research Project 4, studying molecular imaging correlates and biology of activation of the AR-axis in castrate-resistant prostate cancer. This project builds on extensive prior imaging collaborations with prostate cancer specialists Howard Scher, Michael Morris, and Peter Scardino and has led to the development of molecular imaging approaches to androgen receptor (AR) imaging as well as several novel radioantibodies that image downstream effectors of AR signaling.
Steven M. Larson, MD
Research FocusNuclear medicine physician Steven Larson focuses on molecular imaging in animals and humans using high-resolution diagnostic instruments, such as positron emission tomography, and single photon emission tomography.
EducationMD, University of Washington School of Medicine (Seattle)
- The Osborne Lab for Cancer Health Equity
- Tumor Targeting and Cell-trafficking Studies of 131I/124I]-FIAU-labeled Genetically Modified Antigen-specific Lymphocytes
- Noninvasive Diagnosis and Quantitation of Multi-drug Resistance by PET
- Multi-step Targeting in Radioimmunodiagnosis and Radioimmunotherapy
- Scher HI, Beer TM, Higano CS, Anand A, Taplin ME, Efstathiou E, Rathkopf D, Shelkey J, Yu EY, Alumkal J, Hung D, Hirmand M, Seely L, Morris MJ, Danila DC, Humm J, Larson S, Fleisher M, Sawyers CL; Prostate Cancer Foundation/Department of Defense Prostate Cancer Clinical Trials Consortium. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet. 2010 Apr 24;375(9724):1437-46. Epub 2010 Apr 14. PMCID: PMC2948179.
- Rathkopf DE, Morris MJ, Fox JJ, Danila DC, Slovin SF, Hager JH, Rix PJ, Chow Maneval E, Chen I, Gönen M, Fleisher M, Larson SM, Sawyers CL, Scher HI. Phase I study of ARN-509, a novel antiandrogen, in the treatment of castration-resistant prostate cancer. J Clin Oncol. 2013 Oct 1;31(28):3525-30. Epub 2013 Sep 3. PMCID: PMC3782148.