The Steven Leach Lab

By 2020, pancreatic cancer is projected to become the second most common cause of cancer death in the United States. Together with other investigators in the David M. Rubenstein Center for Pancreatic Cancer Research, my research group is focused on improving our understanding of pancreatic cancer biology in a manner that will directly improve and extend the lives of pancreatic cancer patients.

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Pictured: Steven D. Leach

Steven D. Leach, MD

Director, David M. Rubenstein Center for Pancreatic Cancer Research


Research Focus

Physician-scientist Steven Leach studies molecular, genetic, and cellular determinants of pancreatic cancer initiation and progression.


MD, Emory University School of Medicine


  • Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Meszoely IM, Wolfe MS, Hruban RH, Ball DW, Schmid RM, Leach SD. Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 3:565-576, 2003 (supplemental data available at
  • Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. Core signaling pathways in human pancreatic cancers revealed by global genomic analysis. Science, 26:1801-1806, 2008.
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Career Opportunities

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