The Thomas Reiner Lab: Publications

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Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

2019

Pirovano G, Jannetti S, Carter L, Sadique A, Kossatz S, Guru N, De Souza Franca PD, Maeda M, Zeglis B, Lewis J, Humm J, Reiner T. Targeted brain tumor radiotherapy using an Auger emitter. bioRxiv; 2019. doi: 10.1101/649764.

Bacher F, Wittmann C, Nove M, Spengler G, Marć MA, Enyedy EA, Darvasiova D, Rapta P, Reiner T, Arion V (2019) Novel latonduine derived proligands and their copper (II) complexes show cytotoxicity in the nanomolar range in human colon adenocarcinoma cells and in vitro cancer selectivity. Dalton Transactions. doi: 10.1039/c9dt01238a.

Lobatto ME, Binderup T, Robson PM, Giesen LFP, Calcagno C, Witjes J, Fay F, Baxter S, Wessel CH, Eldib M, Bini J, Carlin SD, Stroes ESG, Storm G, Kjaer A, Lewis JS, Reiner T, Fayad ZA, Mulder WJM, Perez-Medina C (2019) Multimodal positron emission tomography imaging to quantify uptake of 89Zr-labeled liposomes in the atherosclerotic vessel wall. Bioconjug Chem. doi: 10.1021/acs.bioconjchem.9b00256.

Khera E, Zhang L, Roberts S, Nessler I, Sandoval D, Reiner T, Thurber G (2019) Blocking Glucagon Like Peptide-1 Receptors in the Exocrine Pancreas Improves Specificity for Beta Cells in a Mouse Model of Type 1 Diabetes. Journal of Nuclear Medicine. jnumed. 118.224881.

Vargas SH, Kossatz S, Voss J, Ghosh SC, Cao HST, Simien J, Reiner T, Dhingra S, Fisher WE, Azhdarinia A (2019) Specific targeting of somatostatin receptor subtype-2 for fluorescence-guided surgery. Clinical Cancer Research. clincanres. 3312.2018.

2018

Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Perez-Medina C, Calcagno C, Fisher EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R (2018) Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates. Nat Biomed Eng 2(5):279-292.

Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J (2018) Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance. Immunity 49:819–828.e6.

Gonzales J, Kossatz S, Roberts S, Pirovano G, Brand C, Pérez-Medina C, Donabedian P, de la Cruz MJ, Mulder WJM, Reiner T (2018) Nanoemulsion-Based Delivery of Fluorescent PARP Inhibitors in Mouse Models of Small Cell Lung Cancer. Bioconjug Chem 29:3776–3782.

Pirovano G, Roberts S, Brand C, Donabedian PL, Mason C, de Souza PD, Higgins GS, Reiner T (2018) [18F]FE-OTS964: a Small Molecule Targeting TOPK for In Vivo PET Imaging in a Glioblastoma Xenograft Model. Mol Imaging Biol, published online; doi: http://10.1007/s11307-018-1288-6.

Senders ML, Hernot S, Carlucci G, van de Voort JC, Fay F, Calcagno C, Tang J, Alaarg A, Zhao Y, Ishino S, Palmisano A, Boeykens G, Meerwaldt AE, Sanchez-Gaytan BL, Baxter S, Zendman L, Lobatto ME, Karakatsanis NA, Robson PM, Broisat A, Raes G, Lewis JS, Tsimikas S, Reiner T, Fayad ZA, Devoogdt N, Mulder WJM, Pérez-Medina C (2018) Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis. JACC Cardiovasc Imaging. pii: S1936-878X(18)30753-8; doi: http://10.1016/j.jcmg.2018.07.027.

Brand C, Sadique A, Houghton JL, Gangangari K, Ponte JF, Lewis JS, Pillarsetty NVK, Konner JA, Reiner T (2018) Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate. EJNMMI Res 8:87.

Krebs S, Ahad A, Carter L, Eyquem J, Brand C, Bell M, Ponomarev V, Reiner T, Meares CF, Gottschalk S, Sadelain M, Larson SM, Weber WA (2018) Antibody with infinite affinity for in vivo tracking of genetically engineered lymphocytes. J Nucl Med. 59(12):1894-1900.

Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes EDG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fischer EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R (2018). “Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates.” Nature Biomedical Engineering 2(5): 279-292.

Donabedian PL, Kossatz S, Engelbach JA, Jannetti SA, Carney B, Weber W, Garbow JR, Reiner T (2018) Discriminating Radiation Necrosis from Recurrent Tumor with [18F]PARPi and Amino Acid PET in Mouse Models. EJNMMI Res 8:59.

Roberts S, Andreou C, Choi C, Donabedian P, Jayaraman M, Pratt EC, Tang J, Pérez-Medina C, de la Cruz MJ, Mulder WJM, Grimm J, Kircher M, Reiner T (2018) Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer. Chem Sci 9:5646–5657.

Carney B, Kossatz S, Lok BH, Schneeberger V, Gangangari KK, Pillarsetty NVK, Weber WA, Rudin CM, Poirier JT, Reiner T (2018) Target engagement imaging of PARP inhibitors in small-cell lung cancer. Nat Commun 9:176.

Jannetti SA, Carlucci G, Carney B, Kossatz S, Shenker L, Carter LM, Salinas B, Brand C, Sadique A, Donabedian PL, Cunanan KM, Gönen M, Ponomarev V, Zeglis BM, Souweidane MM, Lewis JS, Weber WA, Humm JL, Reiner T (2018) PARP1-Targeted Radiotherapy in Mouse Models of Glioblastoma. J Nucl Med 59:1225–1233.

Kossatz S, Carney B, Farley C, Drain CM, Weber WA, Reiner T (2018) Direct imaging of drug distribution and target engagement of the PARP inhibitor rucaparib. J Nucl Med 59:1316–1320.

Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum JL, Mulder WJM, Pérez-Medina C, Tsimikas S (2018) PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis. J Am Coll Cardiol 71:321–335.

Meyer JP, Tully KM, Jackson J, Dilling TR, Reiner T, Lewis JS (2018) Bioorthogonal Masking of Circulating Antibody-TCO Groups Using Tetrazine-Functionalized Dextran Polymers. Bioconjug Chem 29:538–545.

Srimathveeravalli G, Abdel-Atti D, Pérez-Medina C, Takaki H, Solomon SB, Mulder WJM, Reiner T (2018) Reversible Electroporation-Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With 89Zr-Labeled Reporter Nanoparticles. Mol Imaging, published online; doi: 10.1177/1536012117749726.

Strome A, Kossatz S, Karassawa Zanoni D, Rajadhyaksha M, Patel S, Reiner T (2018) Current Practice and Emerging Molecular Imaging Technologies in Oral Cancer Screening. Molecular Imaging, published online; doi: 10.1177/1536012118808644

2017

Tang, J., Salloum, D., Carney, B., Brand, C., Kossatz, S., Sadique, A., Lewis, J.S., Weber, W.A., Wendel, H.G., and Reiner, T. (2017). Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A 114, E7441-E7449.

Kossatz S, Weber W, Reiner T (2017) Detection and Delineation of Oral Cancer With a PARP1-Targeted Optical Imaging Agent. Mol Imaging; published online; doi: 10.1177/1536012117723786

Brand C, Iacono P, Pérez-Medina C, Mulder WJM, Kircher MF, Reiner T (2017) Specific Binding of Liposomal Nanoparticles through Inverse Electron-Demand Diels-Alder Click Chemistry. ChemistryOpen 6:615–619.

Pérez-Medina C, Hak S, Reiner T, Fayad ZA, Nahrendorf M, Mulder WJM (2017) Integrating nanomedicine and imaging. Philos Trans A Math Phys Eng Sci 375

Büchel GE, Kossatz S, Sadique A, Rapta P, Zalibera M, Bucinsky L, Komorovsky S, Telser J, Eppinger J, Reiner T, Arion VB (2017) cis-Tetrachlorido-bis(indazole)osmium(iv) and its osmium(iii) analogues: paving the way towards the cis-isomer of the ruthenium anticancer drugs KP1019 and/or NKP1339. Dalton Trans 46:11925–11941.

Alaarg A, Senders ML, Varela-Moreira A, Pérez-Medina C, Zhao Y, Tang J, Fay F, Reiner T, Fayad ZA, Hennink WE et al. (2017) A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis. J Control Release 262:47–57

Ghosh SC, Hernandez Vargas S, Rodriguez M, Kossatz S, Voss J, Carmon KS, Reiner T, Schonbrunn A, Azhdarinia A (2017) Synthesis of a Fluorescently Labeled (68)Ga-DOTA-TOC Analog for Somatostatin Receptor Targeting. ACS Med Chem Lett 8:720–725.

Fay F, Hansen L, Hectors SJCG, Sanchez-Gaytan BL, Zhao Y, Tang J, Munitz J, Alaarg A, Braza MS, Gianella A, Aaronson SA, Reiner T, Kjems J, Langer R, Hoeben FJM, Janssen HM, Calcagno C, Strijkers GJ, Fayad ZA, Pérez-Medina C, Mulder WJM (2017) Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging. Bioconjug Chem 28:1413–1421.

Haedicke K, Brand C, Omar M, Ntziachristos V, Reiner T, Grimm J (2017) Sonophore labeled RGD: a targeted contrast agent for optoacoustic imaging. Photoacoustics 6:1–8.

Beldman TJ, Senders ML, Alaarg A, Pérez-Medina C, Tang J, Zhao Y, Fay F, Deichmöller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E (2017) Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis. ACS Nano 11:5785–5799.

Vinegoni C, Fumene Feruglio P, Brand C, Lee S, Nibbs AE, Stapleton S, Shah S, Gryczynski I, Reiner T, Mazitschek R et al. (2017) Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging. Nat Protoc 12:1472–1497.

Büchel GE, Carney B, Tang J, Zeglis BM, Eppinger J, Reiner T (2017) A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting. J Vis Exp Mar 09(121).

Tang J, Pérez-Medina C, Zhao Y, Sadique A, Mulder WJ, Reiner T (2017) A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines. J Vis Exp, Mar 04(121).

Carney B, Kossatz S, Reiner T (2017) Molecular Imaging of PARP. J Nucl Med 58:1025–1030.

Kossatz S, Carney B, Schweitzer R, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber W, Souweidane MM, Reiner T (2017) Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer Res 77:2112–2123.

Carlucci G, Carney B, Sadique A, Vansteene A, Tang J, Reiner T (2017) Evaluation of [(18)F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer. Nucl Med Biol 48:9–15.

Brand C, Longo V, Groaning M, Weber WA, Reiner T (2017) Development of a new folate-derived 68Ga-based PET imaging agent. Mol Imaging Biol 19:754–761.

Keliher EJ, Ye Y-X, Wojkiewicz GR, Aguirre A, Tricot B, Senders M, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Chen J, Swirski FK, Hooker J, Mulder WJM, Weissleder R, Nahrendorf M (2017) Polyglucose nanoparticles with rapid renal elimination and high macrophage avidity for PET imaging in ischemic heart disease. Nature Communications, 8:14064. doi: 10.1038/ncomms14064.

Senders ML, Fayad ZA, Reiner T, Mulder WJ, Pérez-Medina C (2017) Imaging-guided revival of nanomedicine. Nanomedicine (Lond); 12(2):89-90.

2016

Tang J, Baxter S, Menon A, Alaarg A, Sanchez-Gaytan BL, Fay F, Zhao Y, Ouimet M, Braza MS, Longo VA, Abdel-Atti D, Duivenvoorden R, Calcagno C, Storm G, Tsimikas S, Moore KJ, Swirski FK, Nahrendorf M, Fisher EA, Pérez-Medina C, Fayad ZA, Reiner T, Mulder WJ (2016) Immune cell screening of a nanoparticle library improves atherosclerosis therapy. Proc Natl Acad Sci U S A 113:E6731–E6740.

Adumeau P, Carnazza KE, Brand C, Carlin S, Reiner T, Agnew BJ, Lewis JS, Zeglis BM (2016) A Pretargeted Approach for the Multimodal PET/NIRF Imaging of Colorectal Cancer. Theranostics 6:2267–2277.

Cook BE, Adumeau P, Membreno R, Carnazza KE, Brand C, Reiner T, Agnew BJ, Lewis JS, Zeglis BM (2016) Pretargeted PET Imaging Using a Site-Specifically Labeled Immunoconjugate. Bioconjug Chem 27:1789–1795.

Büchel GE, Carney B, Shaffer TM, Tang J, Austin C, Arora M, Zeglis BM, Grimm J, Eppinger J, Reiner T (2016) Near-Infrared Intraoperative Chemiluminescence Imaging. ChemMedChem 20;11(18):1978-82

Pérez-Medina C, Abdel-Atti D, Tang J, Zhao Y, Fayad ZA, Lewis JS, Mulder WJ, Reiner T (2016) Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy. Nat Commun 7:11838.

Kossatz S, Brand C, Gutiontov S, Liu JTC, Lee NY, Gönen M, Weber WA, Reiner T (2016) Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. Scientific Reports 6:21371.

Pérez-Medina C, Binderup T, Lobatto ME, Tang J, Calcagno C, Giesen L, Wessel CH, Witjes J, Ishino S, Baxter S, Zhao Y, Ramachandran S, Eldib M, Sánchez-Gaytán BL, Robson PM, Bini J, Granada JF, Fish KM, Stroes ES, Duivenvoorden R, Tsimikas S, Lewis JS, Reiner T, Fuster V, Kjær A, Fisher EA, Fayad ZA, Mulder WJ (2016) In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models. JACC Cardiovasc Imaging 9:950–961.

Kossatz S, Weber WA, Reiner T (2016) Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell Carcinoma. PloS one 11:e0147752.

2015

Meyer JP, Houghton JL, Kozlowski P, Abdel-Atti D, Reiner T, Pillarsetty NV, Scholz WW, Zeglis BM, Lewis JS (2015) (18)F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels-Alder Click Chemistry. Bioconjug Chem doi: 10.1021/acs.bioconjchem.5b00504

Carney B, Carlucci G, Salinas B, Di Gialleonardo V, Kossatz S, Vansteene A, Longo VA, Bolaender A, Chiosis G, Keshari KR, Weber WA, Reiner T (2015) Non-invasive PET imaging of PARP1 expression in glioblastoma. Mol Imaging Biol doi: 10.1007/s11307-015-0858-0

Salinas B, Irwin CP, Kossatz S, Bolaender A, Chiosis G, Pillarsetty N, Weber WA, Reiner T (2015) Radioiodinated PARP1 tracers for glioblastoma imaging. EJNMMI Res 5(1):123.

Tang J, Lobatto ME, Hassing L, van der Staay S, van Rijs SM, Calcagno C, Braza MS, Baxter S, Fay F, Sanchez-Gaytan BL, Duivenvoorden R, Sager H, Astudillo YM, Leong W, Ramachandran S, Storm G, Pérez-Medina C, Reiner T, Cormode DP, Strijkers GJ, Stroes ES, Swirski FK, Nahrendorf M, Fisher EA, Fayad ZA, Mulder WJ (2015) Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation. Sci Adv 1(3). pii: e1400223.

Zeglis BM, Brand C, Abdel-Atti D, Carnazza KE, Cook BE, Carlin S, Reiner T, Lewis JS (2015) Optimization of a Pretargeted Strategy for the PET Imaging of Colorectal Carcinoma via the Modulation of Radioligand Pharmacokinetics. Mol Pharm 12(10):3575-87.

Paulus A, Desai P, Carney B, Carlucci G, Reiner T, Brand C, Weber WA (2015) Development of a clickable bimodal fluorescent/PET probe for in vivo imaging. EJNMMI Res 5(1):120.

Pérez-Medina C, Tang J, Abdel-Atti D, Hogstad B, Merad M, Fisher EA, Fayad ZA, Lewis JS, Mulder WJ, Reiner T (2015) PET Imaging of Tumor-Associated Macrophages with 89Zr-Labeled High-Density Lipoprotein Nanoparticles. J Nucl Med 56:1272–1277.

Carlucci G, Carney B, Brand C, Kossatz S, Irwin CP, Carlin SD, Keliher EJ, Weber W, Reiner T (2015) Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma. Mol Imaging Biol 17(6):848-55.

Reiner T, Lewis JS, Zeglis BM (2015) Harnessing the bioorthogonal inverse electron demand Diels-Alder cycloaddition for pretargeted PET imaging. J Vis Exp e52335.

Lohrmann C, Zhang H, Thorek DL, Desai P, Zanzonico PB, O’Donoghue J, Irwin CP, Reiner T, Grimm J, Weber WA. Cerenkov Luminescence Imaging for Radiation Dose Calculation of a 90Y-Labeled Gastrin-Releasing Peptide Receptor Antagonist., J Nucl Med. 2015 May;56(5):805-11.

2014

Perez-Medina C, Abdel-Atti D, Zhang Y, Longo VA, Irwin CP, Binderup T, Ruiz-Cabello J, Fayad ZA, Lewis JS, Mulder WJ, Reiner T (2014) A modular labeling strategy for in vivo PET and near-infrared fluorescence imaging of nanoparticle tumor targeting. J Nucl Med 55:1706–1711.

Brand C, Abdel-Atti D, Zhang Y, Carlin S, Clardy SM, Keliher EJ, Weber WA, Lewis JS, Reiner T. In Vivo Imaging of GLP-1R with a Targeted Bimodal PET/Fluorescence Imaging Agent. Bioconjug Chem. 2014;25:1323–1330.

Irwin CP, Portorreal Y, Brand C, Zhang Y, Desai P, Salinas B, Weber WA, Reiner T.  PARPi-FL - a Fluorescent PARP1 Inhibitor for Glioblastoma Imaging. Neoplasia. 2014;16:432–440.

Zeglis BM, Emmetiere F, Pillarsetty N, Weissleder R, Lewis JS, Reiner T. Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis. ChemistryOpen. 2014;3:48–53.

Wagner T, Zeglis BM, Groveman S, Hille C, Pothig A, Francesconi LC, Herrmann WA, Kuhn FE, Reiner T. Synthesis of the first radiolabeled (188) Re N-heterocyclic carbene complex and initial studies on its potential use in radiopharmaceutical applications. J Labelled Comp Radiopharm. 2014;57:441–447.

Keliher EJ, Klubnick JA, Reiner T, Mazitschek R, Weissleder R. Efficient Acid-Catalyzed (18) F/(19) F Fluoride Exchange of BODIPY Dyes. ChemMedChem. 2014;9:1368–1373.

Thurber GM, Reiner T, Yang KS, Kohler RH, Weissleder R. Effect of Small-Molecule Modification on Single-Cell Pharmacokinetics of PARP Inhibitors. Mol Cancer Ther. 2014;13:986–995.

Reiner T, Zeglis BM. The inverse electron demand Diels–Alder click reaction in radiochemistry. Journal of Labelled Compounds and Radiopharmaceuticals. J Labelled Comp Radiopharm 2014;57:285–290.

2013

Reiner T, Zeglis BM, The Inverse Electron Demand Diels-Alder Click Reaction in Radiochemistry, Journal of Labelled Compounds and Radiopharmaceuticals, 2013, published online. doi: 10.1002/jlcr.3149.

Emmetiere F, Irwin C, Viola-Villegas NT, Longo V, Cheal SM, Zanzonico P, Pillarsetty N, Weber WA, Lewis JS, Reiner T (2013) 18F-labeled-Bioorthogonal Liposomes for In Vivo Targeting. Bioconjugate chemistry 24:1784–1789.

Jantke D, Marziale AN, Reiner T, Kaus F, Herdtweck E, Raba A, Eppinger J, Synthetic strategies for efficient conjugation of organometallic complexes with pendant protein reactive markers, J Organomet. Chem. 2013, 744:82–91.

Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY, Microfluidic On-Chip Capture-Cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-Component Structures for Biosensor Applications. J Vis Exp. 2013, 79:e50772.

Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Ramaswamy S, Bardeesy N, Hanahan D, DePinho RA, Castro CM, Weissleder R, Targeting Pancreatic Cancer by a Small Molecule allows In Vivo Detection. Neoplasia, 2013, 15(7):684-93.

Zeglis BM, Sevak KK, Reiner T, Mohindra P, Carlin SD, Zanzonico P, Weissleder R, Lewis JS, A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry, Journal of Nuclear Medicine. 2013 May 24, 54:1-8.

Reiner T, Jantke D, Miao X, Marziale AN, Kiefer F, Eppinger J, Phenylalanine - a biogenic ligand with flexible η6- and η6:κ1-coordination at ruthenium(II) centres. Dalton Transactions. 2013, 42:8692-8703.

Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R (2013) Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun 4:1504.

Reiner T, Jantke D, Marziale AN, Raba A, Eppinger J (2013) Metal‐Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes. ChemistryOpen 2:50–54 –Cover.

2012

Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY (2012) On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics. Lab Chip 12:3103–3110.

Chung J, Shao H, Reiner T, Weissleder R, Lee H (2012) Microfluidic Cell Sorter (μFCS) for On‐chip Capture and Analysis of Single Cells. Advanced Healthcare Materials 1:432–436 – Cover.

Reiner T, Lacy J, Keliher EJ, Yang KS, Ullal A, Kohler RH, Vinegoni C, Weissleder R (2012) Imaging therapeutic PARP inhibition in vivo through bioorthogonally developed companion imaging agents. Neoplasia (New York, NY) 14:169–177 – Cover.

Keliher EJ, Reiner T, Thurber GM, Upadhyay R, Weissleder R (2012) Efficient 18F‐Labeling of Synthetic Exendin‐4 Analogues for Imaging Beta Cells. ChemistryOpen 1:177–183.

Yang KS, Budin G, Reiner T, Vinegoni C, Weissleder R (2012) Bioorthogonal imaging of aurora kinase A in live cells. Angewandte Chemie International Edition 51:6598–6603.

2011

Chung HJ, Reiner T, Budin G, Min C, Liong M, Issadore D, Lee H, Weissleder R (2011) Ubiquitous detection of gram-positive bacteria with bioorthogonal magnetofluorescent nanoparticles. ACS Nano 5:8834–8841.

Roberts VM, Stein V, Reiner T, Lemonidou A, Li X, Lercher JA (2011) Towards quantitative catalytic lignin depolymerization. Chemistry 17:5939–5948.

Reiner T, Keliher EJ, Earley S, Marinelli B, Weissleder R (2011) Synthesis and in vivo imaging of a 18F-labeled PARP1 inhibitor using a chemically orthogonal scavenger-assisted high-performance method. Angew Chem Int Ed Engl50:1922–1925.

Liong M, Fernandez-Suarez M, Issadore D, Min C, Tassa C, Reiner T, Fortune SM, Toner M, Lee H, Weissleder R (2011) Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance. Bioconjug Chem 22:2390–2394.

Ullal AV, Reiner T, Yang KS, Gorbatov R, Min C, Issadore D, Lee H, Weissleder R (2011) Nanoparticle-mediated measurement of target-drug binding in cancer cells. ACS Nano 5:9216–9224.

Hendricks JA, Keliher EJ, Marinelli B, Reiner T, Weissleder R, Mazitschek R (2011) In Vivo PET Imaging of Histone Deacetylases by (18)F-Suberoylanilide Hydroxamic Acid ((18)F-SAHA). J Med Chem 54:5576–5582.

Keliher EJ, Reiner T, Turetsky A, Hilderbrand SA, Weissleder R (2011) High-yielding, two-step 18F labeling strategy for 18F-PARP1 inhibitors. ChemMedChem 6:424–427.

Budin G, Yang KS, Reiner T, Weissleder R (2011) Bioorthogonal probes for polo-like kinase 1 imaging and quantification. Angew Chem Int Ed Engl 50:9378–9381.

Marziale AN, Jantke D, Faul SH, Reiner T, Herdtweck E, Eppinger J (2011) An efficient protocol for the palladium-catalysed Suzuki–Miyaura cross-coupling. Green Chem 13:169–177.

Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C et al. (2011) Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A 108:12815–12820.

2010

Reiner T, Waibel M, Marziale AN, Jantke D, Kiefer FJ, Fässler TF, Eppinger J (2010) η6-Arene complexes of ruthenium and osmium with pendant donor functionalities. Journal of Organometallic Chemistry 695:2667–2672.

Reiner T, Kohler RH, Liew CW, Hill JA, Gaglia J, Kulkarni RN, Weissleder R (2010) Near-infrared fluorescent probe for imaging of pancreatic Beta cells. Bioconjug Chem 21:1362–1368.

Marziale AN, Faul SH, Reiner T, Schneider S, Eppinger J (2010) Facile palladium catalyzed Suzuki–Miyaura coupling in air and water at ambient temperature. Green Chemistry 12:35–38 – Inside Cover.

Reiner T, Earley S, Turetsky A, Weissleder R (2010) Bioorthogonal small-molecule ligands for PARP1 imaging in living cells. Chembiochem 11:2374–2377.

2009

Reiner T, Jantke D, Raba A, Marziale AN, Eppinger J (2009) Side chain functionalized η5-tetramethyl cyclopentadienyl complexes of Rh and Ir with a pendant primary amine group. Journal of Organometallic Chemistry 694:1934–1937.

Reiner T, Naraschewski FN, Eppinger J (2009) 31P NMR assays for rapid determination of enantiomeric excess in catalytic hydrosilylations and transfer hydrogenations. Tetrahedron: Asymmetry 20:362–367.