The focus of my laboratory is to understand the genomic basis of tumor development and progression. We use both large-scale genomic analyses and functional dissection to elucidate the drivers of oncogenesis. Using this information, we seek to develop improved diagnostic and therapeutic modalities for human cancers.
Timothy A. Chan, MD, PhD
Research FocusPhysician-scientist Timothy Chan focuses on the identification and characterization of tumor suppressors in glioblastoma and breast cancer.
- MD, PhD, The Johns Hopkins University School of Medicine
- Veeriah S, Taylor BS, Meng S, Fang F, Yilmaz E, Vivanco I, Janakiraman M, Schultz N, Hanrahan AJ, Pao W, Ladanyi M, Sander C, Heguy A, Holland EC, Paty PB, Mischel PS, Liau L, Cloughesy TF, Mellinghoff IK, Solit DB, Chan TA. Somatic mutations of the Parkinson’s disease-associated gene PARK2 in glioblastoma and other human malignancies. Nat Genet. 2010 Jan;42(1):77-82. doi: 10.1038/ng.491. Epub 2009 Nov 29.
- Fang F, Turcan S, Rimner A, Kaufman A, Giri D, Morris LG, Shen R, Seshan V, Mo Q, Heguy A, Baylin SB, Ahuja N, Viale A, Massague J, Norton L, Vahdat LT, Moynahan ME, Chan TA. Breast cancer methylomes establish an epigenomic foundation for metastasis. Sci Transl Med. 2011 Mar 23;3(75):75ra25. doi: 10.1126/scitranslmed.3001875.
- Era of Hope Scholar, Department of Defense (2012)
- Frederick R. Adler Chair for Junior Faculty, Memorial Sloan Kettering Cancer Center (2012)
- Member, American Society of Clinical Investigation (2012)
- Distinguished Scientist Award, Sontag Foundation (2010)
- Han-Mo Koo Memorial Lectureship Award, Van Andel Institute (2010)
- Clinical Scientist Development Award, Doris Duke Charitable Foundation (2009)
- Scholar Award, Flight Attendant Medical Research Institute (2008)
- Louis V. Gerstner Investigator Award, Memorial Sloan Kettering Cancer Center (2008)