The laboratory investigates programmed cell death, a cellular process functioning to maintain tissue homeostasis and eliminate damaged or unwanted cells in multicellular organism. Programmed cell death plays crucial roles in development, immune responses, and many other physiological events. Malfunction of programmed cell death can lead to diseases such as cancer, immune disorders, and neurodegenerative diseases. We employ multiple approaches to study the molecular basis of programmed cell death. We also seek to translate our basic research findings into novel cancer therapies.
Xuejun Jiang, PhD
Research FocusCell biologist Xuejun Jiang studies programmed cell death, molecular mechanisms, and their roles in tumorigenesis.
- PhD, University of Texas Southwestern Medical Center at Dallas
- Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC, Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science. 2003 Jan 10;299(5604):223-6.
- Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 2007 Jan 12;128(1):129-39.
- Louis and Allston Boyer Young Investigator Award for Basic Research, Memorial Sloan Kettering Cancer Center (2007)
- Scholar, American Cancer Society (2007-2010)
- Catherine and Frederick Adler Chair for junior faculty, Memorial Sloan Kettering Cancer Center (2006)
- V Scholar, The V Foundation for Cancer Research (2004-2006 )
- Alfred Bressler Scholar, Alref W. Bresller Scholars Fund (2004-2007)
- Sigma Xi Award, UT Southwestern (1998)
- Robert A. Welch Predoctoral Fellowship, UT Southwestern (1995-1999)