The Ying-Xian Pan Lab: Publications

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Le Rouzic V, Narayan A, Hunkle A, Marrone GF, Lu Z, Majumdar S, Xu J, Pan YX and Pasternak GW. Anesth Analg. 128:365-373, 2019.

Lu Z, Xu J, Xu M, Rossi GC, Majumdar S, Pasternak GW and Pan YX. Truncated mu-opioid receptors with 6 transmembrane domains are essential for opioid analgesia. Anesth Analg. 126:1050-1057, 2018.

Huang XP, Che T, Mangano TJ, Le Rouzic V, Pan YX, Majumdar S, Cameron MD, Baumann MH, Pasternak GW and Roth BL. Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo. JCI Insight. 2017 Nov 16;2(22). pii: 97222. doi: 10.1172/jci.insight.97222. [Epub ahead of print].

Baumann MH, Majumdar S, Le Rouzic V, Hunkele A, Uprety R, Huang XP, Xu J, Roth BL, Pan YX and Pasternak GW. Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace. Neruopharmacology. 2017 Aug 12. pii: S0028-3908(17)30383-0. doi: 10.1016/j.neuropharm.2017.08.016. [Epub ahead of print].

Marrone GF, Le Rouzic V, Varadi A, Xu J, Rajadhyaksha AM, Majumdar S, Pan YX and Pasternak GW. Genetic dissociation of morphine analgesia from hyperalgesia in mice. Psychopharmacology. 234:1891-1900, 2017.

Pan L, Pasternak DA, Xu J, Xu M, Lu ZG, Pasternak GW and Pan YX. Isolation and characterization of alternatively spliced variants of the mouse sigma1 receptor gene, Sigmar1. PLoS One, 12(3):e0174694. doi: 10.1371/journal.pone.0174694. eCollection 2017.

Xu J, Lu ZG, Narayan A, Le Rouzic VP, Xu M, Hunkele A, Brown TG, Hoefer WF, Rossi GC, Rice R, Martinez-Rivera A, Rajadhyaksha AM, Catergni L, Bassoni DL, Pasternak GW and Pan YX. Alternatively spliced C-termini of mu opioid receptors impact morphine action. J Clin. Invest. 127:1561-1573, 2017.

Marrone GF, Lu Z, Rossi G, Narayan A, Hunkele A, Marx S, Xu J, Pintar J, Majumdar S, Pan YX and Pasternak GW. Tetrapeptide endomorphin analogs require both full length and truncated splice variants of the mu opioid receptor gene Oprm1 for analgesia. ACS Chem. Neurosci. 7:1717-1727, 2016.

Varade A, Marrone GF, Palmer TC, Narayan A, Szabe MR, Le Rouzic V, Grinnell SG, Subrath JJ, Warner E, Kalra S, Hunkele A, Pagirske J, Ean SO, Medina JM, Xu J, Pan YX, Borics A, Pasternak GW, McLaughlin JP and Majumdar S. Mitragynine/Corynantheidine presudoindoxyls as opioid analgesics with mu agonism and delta antagonism, which do not recruit β-arrestub-2. J Med. Chem. 59:8381-8391, 2016.

Grinnell SG, ANsonoff M, Marrone GF, Lu Z, Narayan A, Xu J, Rossi G, Majumdar S, Pan YX, Bassoni DL, Pintar J and Pasternak GW. Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants. Synapse. 70:395-407, 2016.

Marrone GF, Grinnell SG, Lu Z, Rossi GC, Le Rouzic V, Xu J, Majumdar S, Pan YX and Pasternak GW, Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS. Proc. Natl. Acad. Sci. USA. 113:3663-3668, 2016.

Lu ZG, Xu J, Rossi G, Majumdar S, Pasternak GW and Pan YX. Mediation of opioid analgesia by truncated six transmembrane GPCR. J Clin. Invest. 125:2626-2630, 2015.

Xu J, Faskowitz AJ, Rossi GC, Xu M, Lu Z, Pan Y-X and Pasternak GW. Stabilization of morphine tolerance with long-term dosing: Association with selective upregulation of mu-opioid receptor splice variant mRNAs. Proc. Natl. Acad. Sci. USA 112:279-284, 2015.

Xu J, Xu M, Lu ZG, Rossi GC, Kest B, Waxman AR, Pasternak GW and Pan Y-X. Differential expressions of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in brain regions of four inbred mouse strains. PLoS One. 9(10):e111267. 2014.

Xu J, Lu Z, Xu M, Pan L, Deng Y, Xie X, Liu H, Ding S, Hurd YL, Pasternak GW, Klein RJ, Cartegni L, Zhou W, Pan Y-X. A Heroin Addiction Severity-Associated Intronic Single Nucleotide Polymorphism Modulates Alternative Pre-mRNA Splicing of the μ Opioid Receptor Gene OPRM1 via hnRNPH Interactions. J Neurosci. 34:11048-11066. 2014.

Wieskopf JS, Pan Y-X, Marcovitz J, Tuttle AH, Majumdar S, Pidakala J, Pasternak GW, Mogil JS. Broad-spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene. Pain. S0304-3959(14)00333-9, 2014.

Xu J, Xu M, Bolan E, Gilbert AK, Pasternak GW and Pan Y-X. Isolating and characterizing three alternatively spliced mu opioid receptor variants: mMOR-1A, mMOR-1O and mMOR-1P. Synapse, 68:144-152, 2014.

Lu ZG, Xu J, Xu M, Pasternak GW and Pan Y-X. Morphine regulates expression of mu opioid receptor MOR-1A, an intron-retention carboxyl terminal splice variant of the mu opioid receptor (OPRM1) gene via miR-103/miR-107. Mol Pharmacol. 85:368-380, 2014.

Pasternak GW and Pan Y-X. Mu opioids and their receptors: Evolution of a concept. Pharmacol Rev. 65:1257-1317, 2013.

Sillivan SE, Whittard JD, Jacobs MM, Ren Y, Mazloom AR, Caputti F, Horvath M, Keller E, Ma’ayan A, Pan Y-X, Chiang LW and Hurd YL. ELK1 transcription factor linked to dysregulated striatal mu opioid receptor signaling network and OPRM1 polymorphism in human heroin abusers. Bio Psychiatry, 74:511-519, 2013.

Xu J, Xu M, Brown T, Rossi GC, Hurd YL, Inturrisi CE, Pasternak GW and Pan Y-X. Stabilization of the mu opioid receptor by truncated single transmembrane splice variants through a chaperon-like action. J. Biol. Chem. 288:21211-21227, 2013.

Majumdar S, Subrath J, La Rouzic V, Polikar L, Burgmen M, Nagakura K, Ocampo J, Haselton N, Pasternak AR, Grinnell S, Pan Y-X and Pasternak GW. Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated mu opioid receptor (MOR-1) splice variants. J Med Chem. 55: 6352-6362, 2012.

Majumdar, S., Grinnell, S., Le Rouzic, V., Burgman, M., Polikar, L., Ansonoff, M., Pintar, J., Pan, Y.-X., Pasternak, G.W. Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects (2011) Proceedings of the National Academy of Sciences of the United States of America, 108 (49), pp. 19778-19783.

Lefave, C.V., Squatrito, M., Vorlova, S., Rocco, G.L., Brennan, C.W., Holland, E.C., Pan, Y.-X., Cartegni, L.Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas (2011) EMBO Journal, 30 (19), pp. 4084-4097.

Pasternak, G., Pan, Y.-X.Mu opioid receptors in pain management(2011) Acta Anaesthesiologica Taiwanica, 49 (1), pp. 21-25.

Pasternak, G.W., Pan, Y.-X. Mix and Match: Heterodimers and Opioid Tolerance(2011) Neuron, 69 (1), pp. 6-8.

Pan, Y.-X., Pasternak, G.W. Molecular Biology of Mu Opioid Receptors, pp121-160, The Opiate Receptors, ed: Pasternak, G.W., Humana PressIsbn: 978-1-60761-993-2

Xu, J., Xu, M., Rossi, G.C., Pasternak, G.W., Pan, Y.-X. Identification and characterization ofseven new exon 11-associated splice variants of the rat mopioid receptor gene, OPRM1 (2011) Molecular Pain, 7, art. no. 9,