The main interests of our laboratory include transcriptional regulation and function of opioid receptor genes, particularly the mu opioid receptor (OPRM1) gene; pharmacological and physiological significance of such regulation and function; and identification of targets for novel drugs that can control pain and addiction.
- Majumdar, S., Grinnell, S., Le Rouzic, V., Burgman, M., Polikar, L., Ansonoff, M., Pintar, J., Pan, Y.-X., Pasternak, G.W. Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects (2011) Proceedings of the National Academy of Sciences of the United States of America, 108 (49), pp. 19778-19783.
- Lefave, C.V., Squatrito, M., Vorlova, S., Rocco, G.L., Brennan, C.W., Holland, E.C., Pan, Y.-X., Cartegni, L.Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas (2011) EMBO Journal, 30 (19), pp. 4084-4097.