The main interests of my laboratory are to elucidate the mechanism of γ-secretase-dependent Notch signaling and amyloid precursor protein (APP) processing under physiological and pathological conditions and to develop target-based therapies.(1) γ-Secretase represents a novel class of proteases that catalyze proteolysis of substrates within the transmembrane domain,(2)(3) an apparently hydrophobic environment, wherein water is required for peptide hydrolysis. Intramembranous proteases, including γ-secretase, site 2 proteases, rhomboids and signal peptide peptidase, play an essential role in many biological processes ranging from sterol regulation to development.(2)(3) Unraveling the intricacies of these enigmatic proteases is a formidable challenge that requires novel insights and approaches.
Yueming Li, PhD
Research FocusBiochemist Yueming Li studies function and regulation of transmembrane proteases and development of novel protease-based cancer therapies.
- PhD, University of California Berkeley