The main interests of my laboratory are to elucidate the mechanism of γ-secretase-dependent Notch signaling and amyloid precursor protein (APP) processing under physiological and pathological conditions and to develop target-based therapies. γ-Secretase represents a novel class of proteases that catalyze proteolysis of substrates within the transmembrane domain, an apparently hydrophobic environment, wherein water is required for peptide hydrolysis. Intramembranous proteases, including γ-secretase, site 2 proteases, rhomboids and signal peptide peptidase, play an essential role in many biological processes ranging from sterol regulation to development. Unraveling the intricacies of these enigmatic proteases is a formidable challenge that requires novel insights and approaches.
Yueming Li, PhD
Research FocusBiochemist Yueming Li studies function and regulation of transmembrane proteases and development of novel protease-based cancer therapies.
- PhD, University of California Berkeley
- Crump, C.J., Fish, B.A., Castro, S.V., Chau, D.M., Gertsik, N., Ahn, K., Stiff, C., Pozdnyakov, N., Bales, K.R., Johnson, D.S. and Li, Y.M. (2011). Piperidine acetic acid based gamma-secretase modulators directly bind to Presenilin-1. ACS Chem Neurosci 2, 705-710.
- Crump, C.J., Johnson, D.S. and Li, Y.M. (2011). Target of gamma-secretase modulators, presenilin marks the spot. EMBO J 30, 4696-8.