Research Labs

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23 Faculty Members found
Memorial Hospital Research Laboratories
The Antonescu Lab
Cristina R. Antonescu, MD
My sarcoma research laboratory is dedicated to the detection and molecular characterization of diagnostic and prognostic markers in soft tissue sarcomas. Our current research is focused on 4 areas: (1) KIT oncogenic signaling in the pathogenesis of GIST and mechanisms of drug resistance to targeted kinase inhibitor therapies; (2) oncogenic signaling in angiosarcoma, with the characterization of KDR (VEGFR2) activating mutations in breast angiosarcoma and MYC/FLT4 gene amplifications in radiation-associated angiosarcoma; (3) fusion gene discovery and fusion transcript characterization in diagnosis and prognosis of soft tissue tumors; and (4) establishing genetically engineered sarcoma models using CRISPR-cas9 methodology for investigating the step-wise pathogenesis of translocation-associated sarcomas and generate faithful preclinical models for in vitro drug testing.
Human Oncology & Pathogenesis Program
Researchers in the Berger laboratory
Michael F. Berger, PhD
Researcher Michael Berger focuses on massively parallel sequencing of tumor DNA for biomarker discovery and clinical diagnostics.
Memorial Hospital Research Laboratories
Brett S. Carver
Physician-scientist Brett Carver focuses on the identification of molecular pathways involved in prostate cancer initiation and progression.
Human Oncology & Pathogenesis Program
The Cheng Lab
Emily H. Cheng, MD, PhD
Physician-scientist Emily Cheng focuses on the molecular mechanisms of cell death and their implications in tumorigenesis and cancer therapy, with primary emphasis on lung and kidney cancers.
Human Oncology & Pathogenesis Program
Chi Lab
Ping Chi, MD, PhD
Physician-scientist Ping Chi studies genetic and epigenetic mechanisms of transcriptional regulation by oncogenic factors in GIST, MPNST, melanoma and other solid tumors.
Human Oncology & Pathogenesis Program
The James Fagin Lab
James A. Fagin, MD
Physician-scientist James Fagin focuses on the pathogenesis of thyroid cancer and the role of oncogenic kinases.
Human Oncology & Pathogenesis Program
The Katharine Hsu Lab
Katharine C. Hsu, MD, PhD
Physician-scientist Katharine Hsu studies the biology of human natural killer cells and how they contribute to disease processes.
Molecular Pharmacology Program
The Alex Kentsis Lab
Alex Kentsis, MD, PhD
Cancer biologist and pediatric oncologist Alex Kentsis leads research in the functional proteomics and molecular pharmacology of refractory childhood cancers.
Human Oncology & Pathogenesis Program
Ladanyi lab
Marc Ladanyi, MD
Molecular pathologist Marc Ladanyi studies the molecular pathogenesis of sarcomas, lung cancer, and mesothelioma.
Human Oncology & Pathogenesis Program
The Levine Lab
Ross L. Levine, MD
<ol> <li>Mechanisms of genetic and epigenetic cooperativity&nbsp; which drive myeloid transformation</li> <li>Elucidating and modeling evolution from hematopoietic stem/progenitor cells to clonal hematopoiesis and then to myeloid malignancies</li> <li>Identification and credentialing novel therapeutic dependencies in myeloid malignancies</li> </ol>