Research Labs

Physician-scientist David R. Jones studies molecular mechanisms governing the development of metastases in lung and esophageal cancers.

Computational biologist Dana Pe’er combines single-cell and spatial profiling technologies with machine learning approaches to address fundamental questions in gene regulation, cellular plasticity and cell-cell communication in the contexts of cancer, immunity and development.

Immunologist Justin Perry investigates homeostatic apoptotic cell clearance and how this process is exploited during cancer development and progression.

Molecular biologist John Petrini investigates the repair of chromosomal breaks and the activation of the DNA-damage-induced cell-cycle checkpoints.

Physician-scientist Luke R.G. Pike studies the mechanistic underpinnings of brain metastasis and seeks to identify translational correlates with outcomes following local or systemic therapy.

Pharmacologist Neal Rosen focuses on understanding biochemical mechanisms underlying phenotypes caused by tyrosine kinase activation in epithelial tumors and developing new therapeutic strategies.

Immunology Program Chair Alexander Rudensky focuses on immunological tolerance and the differentiation and function of T cells.

Human Oncology and Pathogenesis Program Chair Charles Sawyers develops molecularly targeted cancer therapy.