Research Labs

Physician-scientist Omar Abdel-Wahab studies the functional genomics of hematopoietic malignancies.

My research involves the elucidation of genetic and biologic insights of human malignant lymphomas. We leverage large-scale unbiased profiling including genomics, transcriptomics, proteomics to identify candidate oncogenes and proteins that are pathogenetically relevant in lymphoma. We utilize molecular technologies, human tumor tissues and patient-derived xenografts and transgenic animal models to determine the functional significance of novel genes and proteins involved in lymphoma pathogenesis. Using primary tumors as our discovery models, the overall goal of our studies is to understand novel mechanisms of oncogenesis, identify tumor biomarkers and vulnerabilities that will facilitate early detection and precision therapies that improve patient outcomes.

Physician-scientist Katharine Hsu studies the biology of human natural killer cells and how they contribute to disease processes.

Physician-scientist Andrew Intlekofer investigates why cancer cells depend on specific pathways of nutrient metabolism.

Cancer biologist and pediatric oncologist Alex Kentsis leads research in the functional proteomics and molecular pharmacology of refractory childhood cancers.

Cancer biologist Michael Kharas studies RNA regulators of self-renewal in both normal and leukemic hematopoiesis.

Mechanisms of genetic and epigenetic cooperativity which drive myeloid transformation; Elucidating and modeling evolution from hematopoietic stem/progenitor cells to clonal hematopoiesis and then to myeloid malignancies; Identification and credentialing novel therapeutic dependencies in myeloid malignancies

Physician-scientist Megan Lim studies the molecular pathogenesis of lymphoma.

Joan Massagué studies the control of stem cell growth and phenotype in tumor progression, metastasis, and response to therapy.