A selection of recent stem cell papers from members of the Center for Stem Cell Biology is provided below:

Qi Y, Zhang XJ, Renier N, Wu Z, Atkin T, Sun Z, Ozair MZ, Tchieu J, Zimmer B, Fattahi F, Ganat Y, Azevedo R, Zeltner N, Brivanlou AH, Karayiorgou M, Gogos J, Tomishima M, Tessier-Lavigne M, Shi SH, Studer L. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017 Jan 23. doi: 10.1038/nbt.3777

Wang Q, Zou Y, Nowotschin S, Kim SY, Li QV, Soh CL, Su J, Zhang C, Shu W, Xi Q, Huangfu D, Hadjantonakis AK, Massagué J. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. Cell Stem Cell. 2016 Nov 9. pii: S1934-5909(16)30342-3. doi: 10.1016/j.stem.2016.10.002

Zeltner N, Fattahi F, Dubois NC, Saurat N, Lafaille F, Shang L, Zimmer B, Tchieu J, Soliman MA, Lee G, Casanova JL, Studer L. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med. 2016 Nov 14. doi: 10.1038/nm.4220.

Sultan KT, Han Z, Zhang XJ, Xianyu A, Li Z, Huang K, Shi SH. Clonally Related GABAergic Interneurons Do Not Randomly Disperse but Frequently Form Local Clusters in the Forebrain. Neuron. 2016 Oct 5;92(1):31-44. doi: 10.1016/j.neuron.2016.09.033

Policy: Global standards for stem-cell research. Kimmelman J, Hyun I, Benvenisty N, Caulfield T, Heslop HE, Murry CE, Sipp D, Studer L, Sugarman J, Daley GQ. Nature. 2016 May 12;533(7603):311-3. doi: 10.1038/533311a. No abstract available.  

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes. Zhu Z, Li QV, Lee K, Rosen BP, González F, Soh CL, Huangfu D. Cell Stem Cell. 2016 Apr 27. pii: S1934-5909(16)30002-9. doi: 10.1016/j.stem.2016.03.015. [Epub ahead of print]

Tan X, Liu WA, Zhang XJ, Shi W, Ren SQ, Li Z, Brown KN, Shi SH. Vascular Influence on Ventral Telencephalic Progenitors and Neocortical Interneuron Production. Dev Cell. 2016 Mar 21;36(6):624-38. doi: 10.1016/j.devcel.2016.02.023.

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W Zhao H de Stanchina E Gershon MD, Grikscheit TC, Chen S, Studer L. Nature. 2016 Feb 10. doi: 10.1038/nature16951.

Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency. Studer L, Vera E, Cornacchia D. Cell Stem Cell. 2015 Jun 4;16(6):591-600. doi: 10.1016/j.stem.2015.05.004. Review.

Inside-Out Radial Migration Facilitates Lineage-Dependent Neocortical Microcircuit Assembly. He S, Li Z, Ge S, Yu YC, Shi SH. Neuron. 2015 Jun 3;86(5):1159-1166. doi: 10.1016/j.neuron.2015.05.002.

Cell Stem Cell cover

Moving Stem Cells to the Clinic: Potential and Limitations for Brain Repair. Steinbeck JA, Studer L. Neuron. 2015 Apr 8;86(1):187-206. doi: 10.1016/j.neuron.2015.03.002.

New Cell Sources for T Cell Engineering and Adoptive Immunotherapy. Themeli M, Rivière I, Sadelain M. Cell Stem Cell. 2015 Apr 2;16(4):357-366. doi: 10.1016/j.stem.2015.03.011.

Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitors Remyelinate the Brain and Rescue Behavioral Deficits following Radiation. Piao J, Major T, Auyeung G, Policarpio E, Menon J, Droms L, Gutin P, Uryu K, Tchieu J, Soulet D, Tabar V. Cell Stem Cell. 2015 Feb 5;16(2):198-210. doi: 10.1016/j.stem.2015.01.004.

Lineage specificity of primary cilia in the mouse embryo. Bangs FK, Schrode N, Hadjantonakis AK, Anderson KV. Nat Cell Biol. 2015 Jan 19. doi: 10.1038/ncb3091.

Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson’s disease model. Steinbeck, JA, Choi SJ, Mrejeru A, Ganat Y, Deisseroth K, Sulzer D, Mosharov EV, Studer L. Nature Biotechnology (2015) doi:10.1038/nbt.3124

Deterministic progenitor behavior and unitary production of neurons in the neocortex. Gao P, Postiglione MP, Krieger TG, Hernandez L, Wang C, Han Z, Streicher C, Papusheva E, Insolera R, Chugh K, Kodish O, Huang K, Simons BD, Luo L8, Hippenmeyer S, Shi SH. Cell. 2014 Nov 6;159(4):775-88. doi: 10.1016/j.cell.2014.10.027.

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation. Funato K, Major, T, Lewis PW, Allis CD and Tabar, V. Science DOI: 10.1126/science.1253799.

Cortical neurogenesis in the absence of centrioles. Insolera R, Bazzi H, Shao W, Anderson KV, Shi SH. Nat Neurosci. 2014 Nov;17(11):1528-35. doi: 10.1038/nn.3831. Epub 2014 Oct 5.

Distinct lineage-dependent structural and functional organization of the hippocampus. Xu HT, Han Z, Gao P, He S, Li Z, Shi W, Kodish O, Shao W, Brown KN, Huang K, Shi SH. Cell. 2014 Jun 19;157(7):1552-64. doi: 10.1016/j.cell.2014.03.067.

An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells.González F, Zhu Z, Shi ZD, Lelli K, Verma N, Li QV, Huangfu D. Cell Stem Cell. 2014 Jun 11. pii: S1934-5909(14)00205-7. doi: 10.1016/j.stem.2014.05.018. [Epub ahead of print]

Metastatic Stem Cells: Sources, Niches, and Vital Pathways. Oskarsson T, Batlle E, Massagué J. Cell Stem Cell. 2014 Mar 6;14(3):306-321. doi: 10.1016/j.stem.2014.02.002. Review.

Serpins promote cancer cell survival and vascular co-option in brain metastasis. Valiente M, Obenauf AC, Jin X, Chen Q, Zhang XH, Lee DJ, Chaft JE, Kris MG, Huse JT, Brogi E, Massagué J. Cell. 2014 Feb 27;156(5):1002-16. doi: 10.1016/j.cell.2014.01.040.

Pluripotent stem cells in regenerative medicine: challenges and recent progress. Tabar V, Studer L. Nat Rev Genet. 2014 Jan 17;15(2):82-92. doi: 10.1038/nrg3563.

Reprinted from Cell Stem Cell, Volume 13, Issue 6. Copyright  2013, with permission from Elsevier Inc. Cover design and illustration by Justine Miller and Newsome Design.

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging.  Miller JD, Ganat YM, Kishinevsky S, Bowman RL, Liu B, Tu ET, Mandal PJ, Vera E, Shim J-w, Kriks S, Taldone T, Fusaki N, Tomishima MJ, Krainc D, Milner TA, Rossi DJ, Studer L. Cell Stem Cell, Volume 13, Issue 6, 691-705, 5 December 2013. Copyright  2013 Elsevier Inc. All rights reserved. 10.1016/j.stem.2013.11.006

Specification of Functional Cranial Placode Derivatives from Human Pluripotent Stem Cells.  Dincer Z, Piao J, Niu L, Ganat Y, Kriks S, Zimmer B, Shi SH, Tabar V, Studer L. Cell Rep. 2013 Nov 25. pii: S2211-1247(13)00647-5. doi: 10.1016/j.celrep.2013.10.048. [Epub ahead of print]

Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy. Themeli M, Kloss CC, Ciriello G, Fedorov VD, Perna F, Gonen M, Sadelain M.  Nat Biotechnol. 2013 Aug 11. doi: 10.1038/nbt.2678. [Epub ahead of print]

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG, Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer L. Cell Stem Cell. 2013 May 2;12(5):559-72. doi: 10.1016/j.stem.2013.04.008.

Nrf2 regulates haematopoietic stem cell function. Tsai JJ, Dudakov JA, Takahashi K, Shieh JH, Velardi E, Holland AM, Singer NV, West ML, Smith OM, Young LF, Shono Y, Ghosh A, Hanash AM, Tran HT, Moore MA, van den Brink MR. Nat Cell Biol. 2013 Mar;15(3):309-16. doi: 10.1038/ncb2699. Epub 2013 Feb 24.

Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state. González F, Georgieva D, Vanoli F, Shi ZD, Stadtfeld M, Ludwig T, Jasin M, Huangfu D. Cell Rep. 2013 Mar 28;3(3):651-60. doi: 10.1016/j.celrep.2013.02.005. Epub 2013 Mar 7.

Human pluripotent stem cells: an emerging model in developmental biology. Zhu Z, Huangfu D. Development. 2013 Feb;140(4):705-17. doi: 10.1242/dev.086165.

MEF Promotes Stemness in the Pathogenesis of Gliomas. Bazzoli E, Pulvirenti T, Oberstadt MC, Perna F, Wee B, Schultz N, Huse JT, Fomchenko EI, Voza F, Tabar V, Brennan CW, Deangelis LM, Nimer SD, Holland EC, Squatrito M. Cell Stem Cell. 2012 Dec 7;11(6):836-844. doi: 10.1016/j.stem.2012.09.012.

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression. Lee, G., Ramirez, C.N., Kim, H., Zeltner, N., Liu, B., Radu, C., Bhinder, B., Kim, Y.J., Choi, I.Y., Mukerjee-Clavin, B., Djaballah, H., Studer, L. Nat Biotechnol. 2012 Nov 25. doi: 10.1038/nbt.2435. Epub ahead of print.

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Lafaille FG, Pessach IM, Zhang SY, Ciancanelli MJ, Herman M, Abhyankar A, Ying SW, Keros S, Goldstein PA, Mostoslavsky G, Ordovas-Montanes J, Jouanguy E, Plancoulaine S, Tu E, Elkabetz Y, Al-Muhsen S, Tardieu M, Schlaeger TM, Daley GQ, Abel L, Casanova JL, Studer L, Notarangelo LD. Nature. 2012 Oct 28. doi: 10.1038/nature11583. Epub ahead of print.

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Chambers SM, Qi Y, Mica Y, Lee G, Zhang XJ, Niu L, Bilsland J, Cao L, Stevens E, Whiting P, Shi SH, Studer L. Nat Biotechnol. 2012 Jul 1;30(7):715-20.

Interleukin-22 drives endogenous thymic regeneration in mice. Dudakov JA, Hanash AM, Jenq RR, Young LF, Ghosh A, Singer NV, West ML, Smith OM, Holland AM, Tsai JJ, Boyd RL, van den Brink MR. Science. 2012 Apr 6;336(6077):91-5. Epub 2012 Mar 1.

Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Andreu-Agullo C, Maurin T, Thompson CB, Lai EC. Nature. 2011 Dec 25;481(7380):195-8. doi: 10.1038/nature10712.

A poised chromatin platform for TGF-β access to master regulators. Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang LF, Liu JX, Kim H, Barlas A, Manova-Todorova K, Kaartinen V, Studer L, Mark W, Patel DJ, Massagué J. Cell. 2011 Dec 23;147(7):1511-24.

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal MF, Surmeier DJ, Kordower JH, Tabar V, Studer L. Nature. 2011 Nov; 480(7378):547-51. doi: 10.1038/nature10648.

Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. Lipchina I, Elkabetz Y, Hafner M, Sheridan R, Mihailovic A, Tuschl T, Sander C, Studer L, Betel D. Genes Dev. 2011 Oct 15;25(20):2173-86. doi: 10.1101/gad.17221311.

Cell fate plug and play: direct reprogramming and induced pluripotency. Chambers SM, Studer L. Cell. 2011 Jun 10;145(6):827-30.

miR-371-3 expression predicts neural differentiation propensity in human pluripotent stem cells. Kim H, Lee G, Ganat Y, Papapetrou EP, Lipchina I, Socci ND, Sadelain M, Studer L. Cell Stem Cell. 2011 Jun 3;8(6):695-706.

Genomic safe harbors permit high beta-globin transgene expression in thalassemia induced pluripotent stem cells. Papapetrou EP, Lee G, Malani N, Setty M, Riviere I, Tirunagari LM, Kadota K, Roth SL, Giardina P, Viale A, Leslie C, Bushman FD, Studer L, Sadelain M. Nat Biotechnol. 2011 Jan;29(1):73-8. Epub 2010 Dec 12.

Glioblastoma stem-like cells give rise to tumor endothelium. Wang R, Chadalavada K, Wilshire J, Kowalik U, Hovinga K, Geber A, Fligelman B, Leversha M, Brennan C, Tabar V. Nature. 2010 Dec 9;468(7325):770-1.

Efficient derivation of functional floor plate tissue from human embryonic stem cells. Fasano CA, Chambers SM, Lee G, Tomishima MJ, Studer L. Cell Stem Cell. 2010 Apr 2;6(4):336-47.

Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Charles N, Ozawa T, Squatrito M, Bleau AM, Brennan CW, Hambardzumyan D, Holland EC. Cell Stem Cell. 2010 Feb 5;6(2):141-52.

High levels of Id1 expression define B1 type adult neural stem cells. Nam HS, Benezra R. Cell Stem Cell. 2009 Nov 6;5(5):515-26.

Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Wang X, Tsai JW, Imai JH, Lian WN, Vallee RB, Shi SH. Nature. 2009 Oct 15;461(7266):947-55.

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Lee G, Papapetrou EP, Kim H, Chambers SM, Tomishima MJ, Fasano CA, Ganat YM, Menon J, Shimizu F, Viale A, Tabar V, Sadelain M, Studer L. Nature. 2009 Sep 17;461(7262):402-6. Epub 2009 Aug 19.

Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Papapetrou EP, Tomishima MJ, Chambers SM, Mica Y, Reed E, Menon J, Tabar V, Mo Q, Studer L, Sadelain M. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12759-64. Epub 2009 Jun 23.

Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Bultje RS, Castaneda-Castellanos DR, Jan LY, Jan YN, Kriegstein AR, Shi SH. Neuron. 2009 Jul 30;63(2):189-202.

Chromosomal translocations induced at specified loci in human stem cells. Brunet E, Simsek D, Tomishima M, DeKelver R, Choi VM, Gregory P, Urnov F, Weinstock DM, Jasin M. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10620-5. Epub 2009 Jun 23.

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Chambers SM, Fasano CA, Papapetrou EP, Tomishima M, Sadelain M, Studer L. Nat Biotechnol. 2009 Mar;27(3):275-80. Epub 2009 Mar 1. Erratum in: Nat Biotechnol. 2009 May;27(5):485.

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Bleau AM, Hambardzumyan D, Ozawa T, Fomchenko EI, Huse JT, Brennan CW, Holland EC. Cell Stem Cell. 2009 Mar 6;4(3):226-35.

Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo. Lupu F, Alves A, Anderson K, Doye V, Lacy E. Dev Cell. 2008 Jun;14(6):831-42.

High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L. Cell Stem Cell. 2008 Jun 5;2(6):602-12.

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L. Genes Dev. 2008 Jan 15;22(2):152-65. Erratum in: Genes Dev. 2008 May 1;22(9):1257.

Therapeutic cloning in individual parkinsonian mice. Tabar V, Tomishima M, Panagiotakos G, Wakayama S, Menon J, Chan B, Mizutani E, Al-Shamy G, Ohta H, Wakayama T, Studer L. Nat Med. 2008 Apr;14(4):379-81. Epub 2008 Mar 23.