The Center for Stem Cell Biology (CSCB) was awarded a grant from the New York State Department of Health and the Empire State Stem Cell Board to support training in stem cell research. The grant sponsors five postdoctoral fellows who show exceptional potential for making significant contributions to the field of stem-cell-related research. Our trainees have the opportunity to take advantage of the unique resources available at Memorial Sloan Kettering, ranging from basic developmental biology and genetic lineage tracing to pluripotency, directed differentiation, stem cell engineering, chemical/genetic screening, and regenerative medicine, including clinical-grade cell processing.
Project Title: Human ES-based modeling of pediatric glioblastoma by histone mutations
Qiong Wang, PhD, Research Scholar, Cancer Biology & Genetics Program
Project Title: p53 acts as a switch factor to license master differentiation genes expression by TGF-beta signals
Xinjun Zhang, PhD, Research Scholar, Developmental Biology Program
Project Title: Accelerated Generation of Functional Cortical Neurons from Human Embryonic Stem Cells Using Combinatorial Small-Molecule Treatment
Zengrong Zhu, PhD, Research Fellow, Developmental Biology Program
Project Title: Genome editing in human embryonic stem cells to study the genetics of neonatal diabetes and pancreatic development
Bastian Zimmer, PhD, Research Fellow, Developmental Biology Program
Project Title: Tailored hPSC-based cell therapy for hypopituitarism
Publications and Presentations
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment. He M, Subramanian R, Bangs F, Omelchenko T, Liem Jr KF, Kapoor TM, Anderson KV. Nat Cell Biol. 2014 Jun 22. doi: 10.1038/ncb2988. [Epub ahead of print]
An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells. González F, Zhu Z, Shi ZD, Lelli K, Verma N, Li QV, Huangfu D. Cell Stem Cell. 2014 Jun 11. pii: S1934-5909(14)00205-7. doi: 10.1016/j.stem.2014.05.018. [Epub ahead of print]
BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Dai Q, Andreu-Agullo C, Insolera R, Wong LC, Shi SH, Lai EC. Development. 2013 May;140(9):1892-902. doi: 10.1242/dev.087502.
Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State. Federico González, Daniela Georgieva, Fabio Vanoli, Zhong-Dong Shi, Matthias Stadtfeld, Thomas Ludwig, Maria Jasin, Danwei Huangfu. Cell Rep. 2013 Mar 28;3(3):651-60. doi: 10.1016/j.celrep.2013.02.005. Epub 2013 Mar 7.
Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Andreu-Agullo C, Maurin T, Thompson CB, Lai EC. Nature. 2011 Dec 25;481(7380):195-8. doi: 10.1038/nature10712.
Project Title: Role of Arsenic-Resistant Protein 2 (Ars2) in the Regulation of Adult Neural Stem Cells
Fiona Bangs, PhD, Research Fellow, Developmental Biology Program
Project Title: The Role of Cilia and Centrosomes in Self-Renewal and Differentiation of Mouse Embryonic Stem Cells
Federico González Grassi, PhD, Research Fellow, Developmental Biology Program
Project Title: Understanding the Mechanisms That Govern the Reprogramming of a Somatic Cell to a Pluripotent State.
Jorge Mansilla-Soto, PhD, Research Fellow, Molecular Pharmacology and Chemistry Program
Project Title: Gene Repair and Erythroid Differentiation Potential of Sickle-Cell-Anemia-Induced Pluripotent Stem Cells
Elsa Vera, PhD, Research Fellow, Developmental Biology Program
Project Title: Accelerating in Vitro Neural Aging by Manipulations of Telomerase Function and Its Application for Modeling Late-Onset Disease