an improved ATAC-seq protocol for chromatin accessibility profiling in cells or tissues with reduced mitochondria DNA contamination and substantial improvement of signal-to-background ratio. It can be used to examine the regulatory landscape of chromatin.
Reference: Corces, M.R., et al., An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. Nat Methods, 2017. 14(10): p. 959-962.