Senior Research Scientist, Innovation Lab

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A senior research scientist position is available within the Innovation Lab of Center for Epigenetics Research (CER) for an ambitious and motivated candidate with a wide experience in epigenetics and molecular biology. The core mission of CER is to develop new experimental methodologies in epigenetics research and implement these and existing technologies. The Innovation Lab works in close collaboration with clinicians and scientists at Memorial Sloan Kettering Cancer Center, as well as the computational biology and genome analysis group in CER.

This ideal candidate for this position will be highly proficient in molecular biology and chromatin biology and possess a strong commitment to research excellence. The senior scientist will be responsible for developing and implementing new technologies used to study the function of chromatin-associated proteins. He/she will work closely with the leadership, experimental and computational biologists, and technical staff in the Center.

Job responsibilities

Project and Staff Management (15%)

  • Work with laboratory staff, the manager of the Innovation Lab and the director of CER to define and articulate research directions, new techniques and laboratory procedures for the Innovation Lab
  • Work with laboratory staff to implement new protocols
  • Participate in interviewing, hiring and training new laboratory staff
  • Participate in evaluating and determining the benchmarking needed and the metrics required for building and monitoring the experimental procedures

Operations and Technology Management (20%)

  • Contribute to strategic planning of the Innovation laboratory to maximize throughput of current projects while allowing for innovation and technology development
  • Work with Lab Managers and Project Managers to determine the metrics needed to assess quality of and need for updating laboratory procedures
  • Work with the Computational group to synergize the experimental procedures with the computational analysis
  • Ensure data migration occurs in an efficient and timely manner with regard to the needs of core members and collaborators
  • Work with laboratory members on methods development, and assess accuracy of new methods

Development and implementation of new methods and laboratory procedures (50%)

  • Implement and optimize commonly used methodologies for epigenetics research to address: gene expression (RNAseq, 4SU-seq, GRO-seq), histone modifications (ChlP-seq, native ChIP-seq; ChIP-exo/MNaseseq/DNase-seq), chromatin accessibility (ATAC-seq, MNase-seq), DNA methylation (bisulfite-seq) and chromatin organization (HiC-techniques)
  • Establish quality control metrics of methods as well as raw data output
  • Develop and implement innovative new laboratory methods in epigenetics research

Scientific Expertise, Consultation, and Training (15%)

  • Provide consultation and guidance to research scientists and other members of the Center
  • Guide researchers in choosing the right method for addressing a specific question and train them in sample handling and experimental procedures
  • Assist collaborators with experimental protocols and development of those
  • Plan, organize, and support external collaborative initiatives

Application Requirements

Education level: Doctorate/PhD

  • Extensive hands-on knowledge and experience with the most common high throughput epigenomics profiling techniques such as ChIP-seq, ATAC-seq, Bisulfite sequencing and others
  • Broad experience in molecular biology techniques
  • Excellent knowledge about epigenetics research
  • Strong analytical skills
  • Excellent communication skills, ability to work collaboratively and effectively

Send cover letter & CV to:

Anatasia Gangadin
gangadia@mskcc.org