Rapid Response Pilot Project Awards

Rapid Response Pilot Project Awards provide seed money for investigators to quickly pursue promising research leads.

December 2018

Ping Chi
Understanding the functional impact of cohesin mutations in cancer

Bishoy Faltas (Weill Cornell Medicine)
Dissecting the role of co-occurring FGFR and cell cycle genomic alterations in the sensitivity of urothelial carcinoma to combined FGFR- and CDK4/6-inhibition

Yariv Houvras (Weill Cornell Medicine)
Leveraging cancer genetics to identify the mechanisms of adaptive resistance in RET rearranged cancer

Christopher Klebanoff
Genomic characterization of a “public” neoantigen derived from a PIK3CA hot spot mutation in primary and metastatic cancers

Marc Ladanyi
Amplification of SRC family kinase genes: potentially novel and targetable primary drivers of tumorigenesis

Minkui Luo
Quantitative modeling of the vulnerability of MTAP-deleted cancer cells upon PRMT5 inhibition

Charles Sawyers
Mechanisms of oncogenicity caused by loss-of-function mutations in the DIS3 RNA exosome subunit

Etay Ziv
Mechanisms of functional synonymous DAXX mutations

July 2017

Minkui Luo
Characterization of Cancer-associated CARM1 Variants

Marilyn Resh
Role of Porcupine (Porcn) acyltransferase amplification and mutation in Wnt-driven cancer

Mark Ptashne
Functional analysis of SMARCD1 hotspot mutations associated with human cancer

September 2016

Dirk Remus
Functional Characterization of non-catalytic mutations in DNA polymerase δ associated with cancer

May 2016

Kathryn Anderson
DNA Polymerase δ in development and tumorigenesis

Sarat Chandarlapaty
The Role of SF3B1 Mutations in Breast Cancer and Chronic Lymphocytic Leukemia Pathogenesis

Minkui Luo
Characterization of Potential Oncogenic SET8 Mutants Implicated in Breast Cance

Song-Hai Shi
Function of PDGFRβ in the Developing Mouse Neocortex: Implications on Neocortical Expansion and Glioma

M. Bryan Tsou
A novel mitotic wait signal mediated by the oncoprotein TRIM37

June 2015

Omar Abdel-Wahab
Investigating the oncogenic potential of amplifications and mutations in XPO1

John Chodera
Probing the biophysics of rar RAS mutations

Morgan Huse
Tuning polarized cell migration through the Ras-PI3K axis

Julia Kaltschmidt
Interaction mapping of Ig domain adhesion molecules Contactin-5/Caspr4

Yueming Li
Role of IFITM3 in regulation of gamma-secretase and Notch signaling

Minkui Luo
Characterization of SETD2’s catalytic domain mutations implicated in kidney renal clear cell carcinoma

Marilyn Resh
Role of Hedgehog Acyltransferase (Hhat) amplification and mutation in cancer

Andreas Ventura
Investigating the role of UPF1 mutations in pancreatic adenosquamous carcinoma

March 2015

John Chodera
Automated biophysical characterization of clinically observed kinase point mutations on inhibitor affinity

Mary Goll
Identifying targets of Tet2/Tet3 regulation in normal development and myeloid malignancy

Jerard Hurwitz
Functional analyses of tumor-derived missense mutations in human DNA polymerase epsilon

Scott Keeney
Functional analysis of MLH1 mutations associated with human cancer

Bryan Tsou
Regulation of sensory capability of primary cilia by centriole sub-distal appendages

Hans-Guido Wendel
Characterizing the consequences of TNFRSF14/HVEM receptor mutations in follicular lymphoma

Xiaolan Zhao
Delineating genome stability effects of cancer mutations at a unique domain of POLE

December 2014

Jaclyn Hechtman
Functional characterization of SOX9 alterations in colorectal carcinoma

Prasad Jallepalli
Mechanisms of Chk1-dependent stabilization of replication forks and genome protection

Maria Jasin
Functional analysis of DMP MSK-IMPACT RAD51 cancer mutations

Marc Ladanyi
Defining MDM2 as a therapeutic target in RET-rearranged lung adenocarcinoma with acquired resistance to the RET inhibitor cabozantinib

Eric Lai
Functional analysis of diverse Dicer1 hotspot mutations associated with human cancer

Ming Li
Molecular understanding of tumor-associated sestrin mutations

Christine Mayr
Regulation of surface protein expression through mutations affecting UDPL

John Poirier
Functional impact of the Rlf-Mycl1 gene fusion in a mouse model of small cell lung cancer using CRISPR/Cas9 genome engineering

Jorge Reis-Filho
Defining the mechanistic basis of the PRKD1 E710D mutation as a driver of genetic alteration