A broad range of policy-relevant clinical questions are amenable to research, ranging from comparisons of the implementation approaches for value based care, to understanding comparative differences in a treatment’s measured efficacy in a clinical trial compared to its effectiveness in clinical practice.
Members of the Center engage in research looking at such comparisons using an array of methods including systematic reviews, observational data analyses, and simulation modeling. A high profile example of this type of research within the Center led to MSK rejecting the colorectal cancer drug ziv-aflibercept (Zaltrap®) from its formulary, after determining it was no better than a drug that cost half its price. This action was covered by The New York Times and on 60 Minutes.
Annemans L, Packard CJ, Briggs A, Ray KK. ‘Highest risk–highest benefit’ strategy: a pragmatic, cost-effective approach to targeting use of PCSK9 inhibitor therapies. [published online ahead of print December 11]. Eur Heart J. 2017. doi.org/10.1093/eurheartj/ehx710
Städler N, Shang A, Bosch F, Briggs A, Goede V, Berthier A, Renaudin C, Leblond V. A Systematic Review and Network Meta-Analysis to Evaluate the Comparative Efficacy of Interventions for Unfit Patients with Chronic Lymphocytic Leukemia. Adv Ther. 2016 Oct;33(10):1814-1830. Epub 2016 Aug 17. Review.
Carlsson SV, de Carvalho TM, Roobol MJ, Hugosson J, Auvinen A, Kwiatkowski M, Villers A, Zappa M, Nelen V, Páez A, Eastham JA, Lilja H, de Koning HJ, Vickers AJ, Heijnsdijk EA. Estimating the harms and benefits of prostate cancer screening as used in common practice versus recommended good practice: A microsimulation screening analysis. Cancer. 2016 Nov 15;122(21):3386-3393. doi: 10.1002/cncr.30192. Epub 2016 Jul 26.
Touijer KA, Karnes RJ, Passoni N, Sjoberg DD, Assel M, Fossati N, Gandaglia G, Eastham JA, Scardino PT, Vickers A, Cozzarini C, Montorsi F, Briganti A. Survival Outcomes of Men with Lymph Node-positive Prostate Cancer After Radical Prostatectomy: A Comparative Analysis of Different Postoperative Management Strategies. Eur Urol. 2017 Oct 14. pii: S0302-2838(17)30828-X. doi: 10.1016/j.eururo.2017.09.027. [Epub ahead of print]