Almost every cell in an organism contains the identical DNA sequence; yet different tissues transcribe unique sets of genes. Differences in transcription are mediated in part through epigenetic marks including DNA methylation and histone modifications. Epigenetic regulation is also important for heritable silencing of transcription at transposons, repeated sequences and the inactive X chromosome. Altered epigenetic profiles lead to abnormal development and are almost always detected in cancer genomes. We are interested in understanding the mechanisms of epigenetic regulation and their roles in vertebrate development with a primary focus on the DNA modification, 5-methylcytosine.

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Selected Achievements

Basil O’Connor Scholar, March of Dimes (2012-2014)

Louis V. Gerstner, Jr. Young Investigators Award, Memorial Sloan Kettering Cancer Center (2011-2014)

Postdoctoral Fellow, Damon Runyon Cancer Research Foundation (2007-2009)

Deans Award for Research Excellence, Columbia University (2006)

At Work: Developmental Biologist Mary Goll

At Work: Developmental Biologist Mary Goll

Developmental biologist Mary Goll is uncovering details about a process called DNA methylation, which can alter the expression of cancer genes.