It is well recognized that the cellular context contributes to susceptibility to oncogenic transformation mediated by different “driver” oncogenes. The focus of our laboratory is to discover and understand the critical genetic and epigenetic factors that determine the cellular-context-dependent oncogenesis in distinct cancer types, with a primary focus on sarcoma and melanoma. We use multimodality approaches, including  transcriptome analyses, epigenome mapping, and gene-expression-based high-throughput screens, as well as murine models to understand the mechanisms of pathogenesis and to develop biomarkers and targeted therapies based on insight into disease pathogenesis.

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Selected Achievements

Kimmel Scholar Award, Sidney Kimmel Foundation (2012)

Research Grant, Sarcoma Foundation of America (2012)

Grant, GIST Cancer Awareness Foundation (2012)

Director’s New Innovator Award, National Institutes of Health (2012)

Clinical Scientist Development Award, National Instistutes of Health (2011)

Pictured: Ping Chi

At Work: Physician-Scientist Ping Chi

Ping Chi, a physician-scientist and member of the Human Oncology and Pathogenesis Program, studies genetic and epigenetic changes that cause cancer.