The Mammalian Blastocyst: Development & Stem cells
The in vivo establishment of a bona fide pluripotent cell population, and in vitro derivation, maintenance and differentiation of lineage-specific stem cells.
Gastrulation: A Paradigm for Tissue Morphogenesis
Loss of pluripotency, and the coordination of cell fate specification, epithelial-to-mesencymal transition (EMT) and cell movement drive the formation of the three germ layers; ectoderm, mesoderm & endoderm.
The Generation of Tools and Development of Methods for Live Imaging Mouse Embryos & Stem Cells
The visualization of live cell behaviors operating in situ combined with the power of mouse genetics towards understanding the mechanisms regulating development, homeostasis and disease progression.