Drug development often begins with a probe or assay that allows researchers to rapidly screen for drug molecules that produce a therapeutic effect. We are designing nano-scale probes and sensors that detect important molecules within live cells and tissues. These sensors enable new types of measurements to greatly facilitate drug development, and they allow researchers to ask unprecedented questions, accelerating biomedical discoveries.
TV Galassi, PV Jena, J Shah, G Ao, E Molitor, Y Bram, A Frankel, J Park, J Jessurun, DS Ory, A Haimovitz-Friedman, D Roxbury, J Mittal, M Zheng, R E Schwartz, DA Heller*. “An Optical Nanoreporter of Endolysosomal Lipid Accumulation Reveals Enduring Effects of Diet on Hepatic Macrophages In Vivo.” Science Translational Medicine 10 (2018) eaar2680.
Jena PV, Roxbury D, Galassi TV, Akkari L, Horoszko CP, Iaea DB, Budhathoki-Uprety J, Pipalia N, Haka AS, Harvey JD, Mittal J, Maxfield FR, Joyce JA, Heller DA. A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. ACS Nano. 2017 Sep 12. doi: 10.1021/acsnano.7b04743. [Epub ahead of print]