Allogeneic hematopoietic stem cell transplantation (HSCT) is an important therapy for a variety of cancers, including leukemias, lymphomas, and myeloma. Several complications limit its use, including relapse of malignancy, graft-versus-host disease, and prolonged immune depletion caused by the conditioning required for successful transplantation — all of which can lead to increased morbidity and mortality after allo-HSCT. My laboratory studies clinically relevant problems in HSCT and aims to develop novel therapeutic strategies to improve patient outcome.
Marcel R. M. van den Brink, MD, PhD
Professor
Research Focus
Physician-scientist Marcel R. M. van den Brink studies the immunology of bone marrow transplantation with a particular focus on intestinal microbiome and strategies to enhance thymus and immune reconstitutionEducation
MD, PhD, Universiteit Leiden- Office Phone: 646-888-2304
- Office Fax: 646-422-0452
- Lab Phone: 646-888-2317
- Lab Fax: 646-422-0452
Lab Members
Marcel van den Brink
Lab Head
Hana Andrlova
Visiting Investigator
Gabriel Armijo
Research Technician
Kimon Argyropoulos
Visiting Investigator
Daniel Brereton
Clinical Research Coordinator
Marissa Buchan
Clinical Research Dietitian
Marina Burgos da Silva
Research Scholar
Kristina Caban
SKI Administrative Assistant, Sr.
Annelie Clurman
Clinical Research Specialist
Nicole DeSimone
Administrative Assistant
Melissa Docampo
Graduate Student
Paul Giardina
Clinical Research Specialist
Antonio Gomes
Computational Biologist, Sr.
Pamela Hatfield
Graduate Student
Lorenz Jahn
Research Scholar
Scott James
Assistant Attending Lv. 1
Amina Lazrak
Research Technician, Sr.
Kate Markey
Visiting Investigator
Brandon Ng
Graduate Student
Katherine Nichols
Research Technician
M. Lia Palomba
Hematologic Oncologist
Kanish Patel
Project Coordinator
Jonathan U. Peled
Assistant Attending Lv. 1
Katarina Piasevoli
Administrative Assistant
Yusuke Shono
Visiting Investigator
John Slingerland
Research Project Manager
Melody Smith
Assistant Attending Lv. 1
Jennifer Tsai
Visiting Investigator
Salma Youssef
Research Trainee
Anastasia Kousa
Research Fellow
Publications
- Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulos KV, Shieh JH, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM*, Dudakov JA*. Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injuries. Nature Medicine. 2018; 24(2):239-246. PMC5803436
- Staffas A, Burgos da Silva M, Slingerland AE, Lazrak A, Bare CJ, Holman CD, Docampo MD, Shono Y, Durham B, Pickard AJ, Cross JR, Stein-Thoeringer C, Velardi E, Tsai JJ, Jahn J, Jay H, Lieberman S, Smith OM, Pamer EG, Peled JU, Cohen DE, Jenq RR, van den Brink MRM. Nutritional support from the intestinal microbiota improves hematopoietic reconstitution after bone marrow transplantation in mice. Cell Host & Microbe. 2018; 23(4):447-457. (commentary in Science 2018; 360(6387):394-395 and in Cell Host & Microbe 2018; 23(4):423-424.) PMC5897172
