Immunology Program

The Marcel van den Brink Lab

Research

Marcel R. M. van den Brink, MD, PhD

Immuno-oncology is increasingly becoming an important therapy for a variety of cancers. As Head of the Division of Hematologic Malignancies and an Attending Physician of the Adult Bone Marrow Transplantation Service, I see patients undergoing a bone marrow transplantation. In my lab, I study novel strategies to improve immune therapies for cancer patients with a special emphasis on the role of the intestinal microbiome in (patho)physiology and therapy, Chimeric Antigen Receptor T cell therapy, and regeneration of thymic function to improve T cell immunity.

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Research Projects

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Marcel van den Brink Lab — van den Brink Lab group photo

Featured News

How gut reactions are shaping cancer treatment

Wednesday, April 6, 2022

An explosion of interest in the workings of the gut microbiome is fueling career and funding opportunities in a wide array of fields. MSK's Marcel van ...

How Do Gut Microbes Affect the Success of CAR T Immunotherapy? New Answers From MSK

Monday, March 14, 2022

In an effort to improve patients’ response to immunotherapy, MSK researchers have studied how microorganisms in the gut affect outcomes in people receiving CAR T therapy.

Memorial Sloan Kettering Cancer Center Tops Prestigious List of Highly Cited Researchers

Thursday, November 18, 2021

Memorial Sloan Kettering Cancer Center (MSK) is proud to announce that it is ranked among the top 20 organizations with the greatest number of highly cited scientific researchers worldwide, according to the annual list of Highly Cited Researchers published by the Institute for Scientific Information at Clarivate.

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Publications

Smith M, Dai A, Ghilardi G, Amelsberg KV, Devlin SM, Pajarillo R, Slingerland JB, Beghi S, Herrera PS, Giardina P, Clurman A, Dwomoh E, Armijo G, Gomes ALC, Littmann ER, Schluter J, Fontana E, Taur Y, Park JH, Palomba ML, Halton E, Ruiz J, Jain T, Pennisi M, Afuye AO, Perales MA, Freyer CW, Garfall A, Gier S, Nasta S, Landsburg D, Gerson J, Svoboda J, Cross J, Chong EA, Giralt S, Gill SI, Riviere I, Porter DL, Schuster SJ, Sadelain M, Frey N, Brentjens RJ, June CH, Pamer EG, Peled JU, Facciabene A, van den Brink MRM, Ruella M. Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy. Nat Med. 2022 Mar 14. doi: 10.1038/s41591-022-01702-9. Epub ahead of print. PMID: 35288695.

Miltiadous O, Waters NR, Andrlova H, Dai A, Nguyen CL, Burgos da Silva M, Lindner S, Slingerland J, Giardina P, Clurman A, Armijo GK, Gomes AL, Lakkaraja M, Maslak PG, Scordo M, Shouval R, Staffas A, O’Reilly RJ, Taur Y, Prockop S, Boelens JJ, Giralt S, Perales MA, Devlin SM, Peled JU, Markey KA, van den Brink MRM. Early intestinal microbial features are associated with CD4 T cell recovery after allogeneic hematopoietic transplant. Blood. 2022 Jan 21:blood.2021014255. doi: 10.1182/blood.2021014255. Epub ahead of print. PMID: 35061893.

Peled JU, Gomes ALC, Devlin SM, Littmann ER, Taur Y, Sung AD, Weber D, Hashimoto D, Slingerland AE, Slingerland JB, Maloy M, Clurman AG, Stein-Thoeringer CK, Markey KA, Docampo MD, Burgos da Silva M, Khan N, Gessner A, Messina JA, Romero K, Lew MV, Bush A, Bohannon L, Brereton DG, Fontana E, Amoretti LA, Wright RJ, Armijo GK, Shono Y, Sanchez-Escamilla M, Castillo Flores N, Alarcon Tomas A, Lin RJ, Yáñez San Segundo L, Shah GL, Cho C, Scordo M, Politikos I, Hayasaka K, Hasegawa Y, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Jenq RR, Teshima T, Chao NJ, Holler E, Xavier JB, Pamer EG, van den Brink MRM. Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation. N Engl J Med. 2020 Feb 27;382(9):822-834. doi: 10.1056/NEJMoa1900623.

Markey KA, Schluter J, Gomes ALC, Littmann ER, Pickard AJ, Taylor BP, Giardina PA, Weber D, Dai A, Docampo MD, Armijo GK, Slingerland AE, Slingerland JB, Nichols KB, Brereton DG, Clurman AG, Ramos RJ, Rao A, Bush A, Bohannon L, Covington M, Lew MV, Rizzieri DA, Chao N, Maloy M, Cho C, Politikos I, Giralt S, Taur Y, Pamer EG, Holler E, Perales MA, Ponce DM, Devlin SM, Xavier J, Sung AD, Peled JU, Cross JR, van den Brink MRM. The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD. Blood. 2020 Jul 2;136(1):130-136. doi: 10.1182/blood.2019003369.

Stein-Thoeringer CK, Nichols KB, Lazrak A, Docampo MD, Slingerland AE, Slingerland JB, Clurman AG, Armijo G, Gomes ALC, Shono Y, Staffas A, Burgos da Silva M, Devlin SM, Markey KA, Bajic D, Pinedo R, Tsakmaklis A, Littmann ER, Pastore A, Taur Y, Monette S, Arcila ME, Pickard AJ, Maloy M, Wright RJ, Amoretti LA, Fontana E, Pham D, Jamal MA, Weber D, Sung AD, Hashimoto D, Scheid C8, Xavier JB, Messina JA, Romero K, Lew M, Bush A, Bohannon L, Hayasaka K, Hasegawa Y, Vehreschild MJGT, Cross JR, Ponce DM, Perales MA, Giralt SA, Jenq RR, Teshima T1, Holler E, Chao NJ, Pamer EG, Peled JU, van den Brink MRM. Lactose Drives Enterococcus Expansion to Promote Graft-versus-Host Disease. Science. 2019; 366(6469)1143–1149.

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People

Marcel R. M. van den Brink, MD, PhD

Physician-scientist Marcel R. M. van den Brink studies the immunology of bone marrow transplantation with a particular focus on intestinal microbiome and strategies to enhance thymus and immune reconstitution.
MD, PhD, Universiteit Leiden

vandenbm@mskcc.org: Email Address
646-888-2304: Office Phone
View physician profile: Physician profile

Members

Peter Adintori, MS, RD, CDN — Peter Adintori
Clinical Research Dietitian

Luigi Amoretti
Research Assistant, Molecular Microbiology Facility

Kimon Argyropoulos, MD — Kimon Argyropoulos
Visiting Investigator

Alec Boardman
Hematology Oncology Fellow

Marina Burgos da Silva, MSc, PhD — Marina Burgos da Silva
Research Scholar

Marjorie Cayatte

Graduate Research Assistant

Sophia Chen, MD — Sophia Chen
Research Fellow

Annelie Clurman
Research Project Associate

Harold Elias, MD — Harold Elias
Visiting Investigator

Emily Fontana
Manager, Molecular Microbiology Facility

Leana Harford
Clinical Research Specialist

Pamela Herrera (Hatfield)
Graduate Student

Scott James, MD, PhD — Scott James
Assistant Attending Lv. 1

Zachary Kluger

Research Technician, Molecular Microbiology Facility

Andri Lemarquis

Research Associate

Sarah Lindner, MD — Sarah Lindner
Research Fellow

Meng Lyu

Visiting Investigator

Dylan Manuele
CAR T Cell Research Technician

LeeAnn Marcello
Research Project Associate

Oriana Miltiadous, MD — Oriana Miltiadous
Pediatric Hematology/Oncology Clinical Instructor

Justin Neuberger

Clinical Research Coordinator

Chi Nguyen, PhD Candidate — Chi Nguyen
Graduate Student

M. Lia Palomba, MD — M. Lia Palomba
Hematologic Oncologist

Jenny Paredes Sanchez, PhD — Jenny Paredes Sanchez
Research Fellow

Jonathan U. Peled, MD, PhD — Jonathan U. Peled
Assistant Attending

Katarina Piasevoli
Project Portfolio Manager

Sandeep S. Raj, MD — Sandeep S. Raj
Hematology Oncology Fellow

Adhithi Rajagopalan

Research Fellow

Mihika Shah, BS — Mihika Shah
Project Coordinator

John Slingerland
Research Project Manager

Natalie Smith
Clinical Research Coordinator

Angelica Stephenson
Senior Administrative Assistant

Charlotte Subklewe
Graduate Research Assistant

Roberta Wright
Research Assistant, Molecular Microbiology Facility

Lab Alumni

Katya Ahr, BA — Katya Ahr
Administrative Secretary

Onder Alpdogan

Postdoctoral Research Fellow

Stephanie Benardis, BA, BSN — Stephanie Benardis
SKI Administrative Assistant, Senior

Daniel Brereton
Clinical Research Coordinator

Marissa Buchan , MS, RDN, CDN — Marissa Buchan
Clinical Research Dietitian

Kristina Caban, BA — Kristina Caban
SKI Administrative Assistant, Sr.

Nicole DeSimone, Administrative Secretary — Nicole DeSimone
Administrative Assistant

Barbara Du Rocher D'Aguiar Silva

Graduate Student

Jarrod Dudakov, PhD — Jarrod Dudakov
Senior Research Scientist

Melissa Docampo, PhD — Melissa Docampo
Postdoctoral Fellow

Katrina Edmondson

Administrative Secretary

Gabriel Eisenkolb, MD Candidate — Gabriel Eisenkolb
Graduate Research Assistant

Anna Franklin (Keating)

Postdoctoral Research Fellow

John Gleason

Research Technician

Arnab Ghosh

Research Fellow

Paul Giardina
Research Project Associate

Gabrielle Goldberg

Postdoctoral Research Fellow

Antonio Gomes, PhD — Antonio Gomes
Computational Biologist, Sr.

Kalliopi Grigoriadou

Postdoctoral Research Fellow

Jeremy Grubin

Research Technician

Jens Halm

Postdoctoral Research Fellow

Alan Hanash

Steffen Hartrampf

Research Fellow

Robert R. Jenq, MD — Robert R. Jenq
Assistant Attending, Bone Marrow Transplant

Sheena Kapoor

SKI Administrative Assistant II

Barry Kappel

Research Technician

Theo Kim

Postdoctoral Research Fellow

Chris King

Research Technician

Aleksandra Kirovski-Petrovic

Postdoctoral Research Fellow

Adam Kochman

Research Technician

Fabiana Kreines, BA — Fabiana Kreines
Research Technician

Amina Lazrak, BS — Amina Lazrak
Research Technician, Sr.

Nicole Lee, BA — Nicole Lee
Research Technician

Emily Levy, BS — Emily Levy
Research Technician

Caroline Lindemans
Postdoctoral Research Fellow

Sydney Lu

Graduate Student

Vanessa Lucey (Hubbard)

Research Technician

Florent Malard, MD, PhD — Florent Malard
Research Fellow

Kate Markey, MBBS, PhD — Kate Markey
Assistant Attending Lv. 1

Anna Mertelsmann
Medical Student, University Hospital Eppendorf, Hamburg, Germany

Barbara Morcerf

Administrative Secretary

Christina Muggeo, BA — Christina Muggeo
Administrative Secretary

Stephanie J. Muriglan

Research Technician

Il-Kang Na

Research Fellow

Kanish Patel, BA — Kanish Patel
Project Coordinator

Olaf Penack

Research Fellow

Carmen Perez
Radiation Oncology Resident, Research Fellow

Lia Perez

Postdoctoral Research Fellow

Suelen Perobelli, PhD — Suelen Perobelli
Visiting Research Fellow

Kelly Piersanti
Senior Research Technician to Dr. Lia Palomba

Michael R. Pitter, BA — Michael R. Pitter
Research Technician

Hendrik Poeck

Feodor Lynen Scholar for Experienced Researchers (Alexander von Humboldt-Foundation)

Teresa Ramirez-Montagut

Postdoctoral Research Fellow

Lilly Reilly

Assistant to Marcel van den Brink, MD, PhD

Shalee Richardson

Administrative Secretary

Betsy Rojas

Assistant to Marcel van den Brink, MD, PhD

Jimmy A. Rotolo

Research Technician

Raffaella Schiro

Postdoctoral Research Fellow

Cornelius Schmaltz

Postdoctoral Research Fellow

Annie Slingerland, BA, Smith College — Annie Slingerland
Research Technician, Sr.

Melody Smith, MD — Melody Smith
Assistant Attending Lv. 1

O. Marsinay Smith, BA — O. Marsinay Smith
Senior Research Assistant

Megan Solberg, BA — Megan Solberg
Senior Project Coordinator

Anna Staffas, PhD — Anna Staffas
Research Fellow

Christoph Stein-Thoeringer
Visiting Investigator

Dave Suh

Research Technician

Theis Therway

Research Fellow

Jennifer Tsai, MD — Jennifer Tsai
Visiting Investigator

Andrea Tuckett

Research Associate

Thomas van Huystee

Postdoctoral Research Fellow

Enrico Velardi, PhD — Enrico Velardi
Visiting Investigator

Elisha Waldman

Postdoctoral Research Fellow

Tobias Wertheimer
Graduate Research Assistant

Lucy M. Willis

Research Technician, Graduate Student

Nury Yim
Howard Hughes Medical Institute Medical Research Fellow

Lab Affiliations

Achievements

Head of the Division of Hematologic Malignancies at MSKCC (2008 - present)
Royal Dutch Academy of Sciences (2020)
International Society for Experimental Hematology: Till and McCulloch Lectureship Award (2015)
Alan N. Houghton Chair in Immunology at MSKCC (2007)
Howard Hughes Physician Scientist Award (1996)

Lab News & Events

Tweets by @@vandenBrinkLab?lang=en

Some of our lab members attending the US Open

Celebrating the holidays as a team!

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Research Technician

Apply now

Get in Touch

vandenbm@mskcc.org

Lab Head Email
646-888-2304

Office Phone
646-422-0452

Office Fax
646-888-2317

Lab Phone
646-422-0452

Lab Fax
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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Marcel R. M. van den Brink discloses the following relationships and financial interests:

Ceramedix
Provision of Services
DKMS
Fiduciary Role/Position; Provision of Services
Da Volterra
Provision of Services
Garuda Therapeutics
Provision of Services
GlaxoSmithKline
Provision of Services
Juno Therapeutics
Intellectual Property Rights
King Faisal Specialist Hospital & Research Centre
Provision of Services
LyGenesis, Inc.
Provision of Services

MJH Life Sciences
Provision of Services
Notch Therapeutics
Ownership / Equity Interests; Provision of Services
Pluto Immunotherapeutics
Ownership / Equity Interests; Provision of Services (uncompensated)
Priothera Limited
Provision of Services
Rheos Medicines, Inc
Provision of Services
Seres Therapeutics
Intellectual Property Rights; Ownership / Equity Interests; Provision of Services
Smart Immune SAS
Provision of Services (uncompensated)
WindMIL Therapeutics, Inc.
Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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The Marcel van den Brink Lab

Research

Research Projects

MSK Offers Students a Spectrum of Education Unlike Any Other

Featured News

Publications

People

Members

Achievements

Lab News & Events

Open Positions

Research Technician

Get in Touch

Disclosures

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