Immunology Program

The Marcel van den Brink Lab

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Research

Pictured: Marcel R. M. van den Brink
Marcel R. M. van den Brink, MD, PhD

Immuno-oncology is increasingly becoming an important therapy for a variety of cancers. As Head of the Division of Hematologic Malignancies and an Attending Physician of the Adult Bone Marrow Transplantation Service, I see patients undergoing a bone marrow transplantation. In my lab, I study novel strategies to improve immune therapies for cancer patients with a special emphasis on the role of the intestinal microbiome in (patho)physiology and therapy, Chimeric Antigen Receptor T cell therapy, and regeneration of thymic function to improve T cell immunity.

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Research Projects

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Marcel van den Brink Lab

van den Brink Lab group photo

Featured News

How gut reactions are shaping cancer treatment

An explosion of interest in the workings of the gut microbiome is fueling career and funding opportunities in a wide array of fields. MSK's Marcel van ...
Headshots of MSK hematologic oncologist Jae Park and physician-scientist Marcel van den Brink
How Do Gut Microbes Affect the Success of CAR T Immunotherapy? New Answers From MSK

In an effort to improve patients’ response to immunotherapy, MSK researchers have studied how microorganisms in the gut affect outcomes in people receiving CAR T therapy.
MSK and SKI's Highly Cited Researchers.
Memorial Sloan Kettering Cancer Center Tops Prestigious List of Highly Cited Researchers

Memorial Sloan Kettering Cancer Center (MSK) is proud to announce that it is ranked among the top 20 organizations with the greatest number of highly cited scientific researchers worldwide, according to the annual list of Highly Cited Researchers published by the Institute for Scientific Information at Clarivate.

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Publications

Smith M, Dai A, Ghilardi G, Amelsberg KV, Devlin SM, Pajarillo R, Slingerland JB, Beghi S, Herrera PS, Giardina P, Clurman A, Dwomoh E, Armijo G, Gomes ALC, Littmann ER, Schluter J, Fontana E, Taur Y, Park JH, Palomba ML, Halton E, Ruiz J, Jain T, Pennisi M, Afuye AO, Perales MA, Freyer CW, Garfall A, Gier S, Nasta S, Landsburg D, Gerson J, Svoboda J, Cross J, Chong EA, Giralt S, Gill SI, Riviere I, Porter DL, Schuster SJ, Sadelain M, Frey N, Brentjens RJ, June CH, Pamer EG, Peled JU, Facciabene A, van den Brink MRM, Ruella M. Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy. Nat Med. 2022 Mar 14. doi: 10.1038/s41591-022-01702-9. Epub ahead of print. PMID: 35288695.

Miltiadous O, Waters NR, Andrlova H, Dai A, Nguyen CL, Burgos da Silva M, Lindner S, Slingerland J, Giardina P, Clurman A, Armijo GK, Gomes AL, Lakkaraja M, Maslak PG, Scordo M, Shouval R, Staffas A, O’Reilly RJ, Taur Y, Prockop S, Boelens JJ, Giralt S, Perales MA, Devlin SM, Peled JU, Markey KA, van den Brink MRM. Early intestinal microbial features are associated with CD4 T cell recovery after allogeneic hematopoietic transplant. Blood. 2022 Jan 21:blood.2021014255. doi: 10.1182/blood.2021014255. Epub ahead of print. PMID: 35061893.

Peled JU, Gomes ALC, Devlin SM, Littmann ER, Taur Y, Sung AD, Weber D, Hashimoto D, Slingerland AE, Slingerland JB, Maloy M, Clurman AG, Stein-Thoeringer CK, Markey KA, Docampo MD, Burgos da Silva M, Khan N, Gessner A, Messina JA, Romero K, Lew MV, Bush A, Bohannon L, Brereton DG, Fontana E, Amoretti LA, Wright RJ, Armijo GK, Shono Y, Sanchez-Escamilla M, Castillo Flores N, Alarcon Tomas A, Lin RJ, Yáñez San Segundo L, Shah GL, Cho C, Scordo M, Politikos I, Hayasaka K, Hasegawa Y, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Jenq RR, Teshima T, Chao NJ, Holler E, Xavier JB, Pamer EG, van den Brink MRM. Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation. N Engl J Med. 2020 Feb 27;382(9):822-834. doi: 10.1056/NEJMoa1900623.

Markey KA, Schluter J, Gomes ALC, Littmann ER, Pickard AJ, Taylor BP, Giardina PA, Weber D, Dai A, Docampo MD, Armijo GK, Slingerland AE, Slingerland JB, Nichols KB, Brereton DG, Clurman AG, Ramos RJ, Rao A, Bush A, Bohannon L, Covington M, Lew MV, Rizzieri DA, Chao N, Maloy M, Cho C, Politikos I, Giralt S, Taur Y, Pamer EG, Holler E, Perales MA, Ponce DM, Devlin SM, Xavier J, Sung AD, Peled JU, Cross JR, van den Brink MRM. The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD. Blood. 2020 Jul 2;136(1):130-136. doi: 10.1182/blood.2019003369.

Stein-Thoeringer CK, Nichols KB, Lazrak A, Docampo MD, Slingerland AE, Slingerland JB, Clurman AG, Armijo G, Gomes ALC, Shono Y, Staffas A, Burgos da Silva M, Devlin SM, Markey KA, Bajic D, Pinedo R, Tsakmaklis A, Littmann ER, Pastore A, Taur Y, Monette S, Arcila ME, Pickard AJ, Maloy M, Wright RJ, Amoretti LA, Fontana E, Pham D, Jamal MA, Weber D, Sung AD, Hashimoto D, Scheid C8, Xavier JB, Messina JA, Romero K, Lew M, Bush A, Bohannon L, Hayasaka K, Hasegawa Y, Vehreschild MJGT, Cross JR, Ponce DM, Perales MA, Giralt SA, Jenq RR, Teshima T1, Holler E, Chao NJ, Pamer EG, Peled JU, van den Brink MRM. Lactose Drives Enterococcus Expansion to Promote Graft-versus-Host Disease. Science. 2019; 366(6469)1143–1149.

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People

Pictured: Marcel R. M. van den Brink

Marcel R. M. van den Brink, MD, PhD

  • Physician-scientist Marcel R. M. van den Brink studies the immunology of bone marrow transplantation with a particular focus on intestinal microbiome and strategies to enhance thymus and immune reconstitution.
  • MD, PhD, Universiteit Leiden
[email protected]
Email Address
646-888-2304
Office Phone
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Physician profile

Members

Peter Adintori, MS, RD, CSO, CDN, CNSC
Peter Adintori

Clinical Research Dietitian

Luigi Amoretti
Luigi Amoretti

Research Assistant, Molecular Microbiology Facility

Hana Andrlova
Hana Andrlova

Research Associate

Kimon Argyropoulos, MD
Kimon Argyropoulos

Visiting Investigator

Alec Boardman
Alec Boardman

Hematology Oncology Fellow

Marina Burgos da Silva, MSc, PhD
Marina Burgos da Silva

Research Scholar

Marjorie Cayatte

Graduate Research Assistant

Sophia Chen, MD
Sophia Chen

Research Fellow

Annelie Clurman
Annelie Clurman

Research Project Associate

Anqi Dai
Anqi Dai

Computational Biologist II

Susan De Wolf
Susan De Wolf

Instructor

Harold Elias, MD
Harold Elias

Visiting Investigator

Jacob Fischman
Jacob Fischman

Research Technician

Emily Fontana
Emily Fontana

Manager, Molecular Microbiology Facility

Tyler Funnell
Tyler Funnell

Computational Biologist

Romina Ghale

Research Technician

Brianna Gipson
Brianna Gipson

Research Technician

Leana Harford
Leana Harford

Clinical Research Specialist

Pamela Herrera
Pamela Herrera (Hatfield)

Graduate Student

Scott James, MD, PhD
Scott James

Assistant Attending Lv. 1

Raman Kaur

Administrative Assistant, Sr

Zachary Kluger

Research Technician, Molecular Microbiology Facility

Anastasia Kousa
Anastasia Kousa

Research Fellow

Andri Lemarquis MD, PhD
Andri Lemarquis

Research Associate

Sarah Lindner, MD
Sarah Lindner

Research Fellow

Meng Lyu

Visiting Investigator

Dylan Manuele
Dylan Manuele

CAR T Cell Research Technician

LeeAnn Marcello
LeeAnn Marcello

Research Project Associate

Alyssa Massa
Alyssa Massa

Research Technician

Oriana Miltiadous, MD
Oriana Miltiadous

Pediatric Hematology/Oncology Clinical Instructor

Justin Neuberger

Clinical Research Coordinator

Brandon Ng
Brandon Ng

Graduate Student

Chi Nguyen, PhD Candidate
Chi Nguyen

Graduate Student

Arianna Otero

Administrative Assistant

M. Lia Palomba, MD
M. Lia Palomba

Hematologic Oncologist

Jenny Paredes Sanchez, PhD
Jenny Paredes Sanchez

Research Fellow

Jonathan U. Peled, MD, PhD
Jonathan U. Peled

Assistant Attending

Marissa Peterson
Marissa Peterson

Program Coordinator

Katarina Piasevoli
Katarina Piasevoli

Project Portfolio Manager

Sandeep S. Raj, MD
Sandeep S. Raj

Hematology Oncology Fellow

Adhithi Rajagopalan

Research Fellow

Keimya Sadeghi

Data Engineer

Mihika Shah, BS
Mihika Shah

Project Coordinator

Roni Shouval
Roni Shouval

Assistant Attending, L1

John Slingerland
John Slingerland

Research Project Manager

Natalie Smith
Natalie Smith

Clinical Research Coordinator

Angelica Stephenson

Senior Administrative Assistant

Charlotte Subklewe
Charlotte Subklewe

Graduate Research Assistant

Nicholas Waters

Computational Biologist

Roberta Wright
Roberta Wright

Research Assistant, Molecular Microbiology Facility

Haowen Xiao, MD, PhD
Haowen Xiao

Visiting Investigator

Kristen Victor
Kristen Victor

Senior Research Technician

Lab Alumni
Katya Ahr, BA
Katya Ahr

Administrative Secretary

Onder Alpdogan

Postdoctoral Research Fellow

Gabriel Armijo
Gabriel Armijo

Research Technician

Stephanie Benardis, BA, BSN
Stephanie Benardis

SKI Administrative Assistant, Senior

Daniel Brereton
Daniel Brereton

Clinical Research Coordinator

Marissa Buchan , MS, RDN, CDN
Marissa Buchan

Clinical Research Dietitian

Kristina Caban, BA
Kristina Caban

SKI Administrative Assistant, Sr.

Nicole DeSimone, Administrative Secretary
Nicole DeSimone

Administrative Assistant

Barbara Du Rocher D'Aguiar Silva

Graduate Student

Jarrod Dudakov, PhD
Jarrod Dudakov

Senior Research Scientist

Emmanuel Dwomoh
Emmanuel Dwomoh

Research Technician

Melissa Docampo, PhD
Melissa Docampo

Postdoctoral Fellow

Katrina Edmondson

Administrative Secretary

Gabriel Eisenkolb, MD Candidate
Gabriel Eisenkolb

Graduate Research Assistant

Jeffrey Eng

Research Technician

Anna Franklin (Keating)

Postdoctoral Research Fellow

John Gleason

Research Technician

Arnab Ghosh

Research Fellow

Paul Giardina
Paul Giardina

Research Project Associate

Gabrielle Goldberg

Postdoctoral Research Fellow

Antonio Gomes, PhD
Antonio Gomes

Computational Biologist, Sr.

Kalliopi Grigoriadou

Postdoctoral Research Fellow

Jeremy Grubin

Research Technician

Jyotsna Gupta
Jyotsna Gupta

Research Technician

Jens Halm

Postdoctoral Research Fellow

Alan Hanash
Steffen Hartrampf

Research Fellow

Amanda Holland

Research Fellow

Lorenz Jahn
Lorenz Jahn

Research Scholar

Hillary Jay

Research Technician

Robert R. Jenq, MD
Robert R. Jenq

Assistant Attending, Bone Marrow Transplant

Sheena Kapoor
Sheena Kapoor

SKI Administrative Assistant II

Barry Kappel

Research Technician

Theo Kim

Postdoctoral Research Fellow

Chris King

Research Technician

Aleksandra Kirovski-Petrovic

Postdoctoral Research Fellow

Adam Kochman

Research Technician

Fabiana Kreines, BA
Fabiana Kreines

Research Technician

Amina Lazrak, BS
Amina Lazrak

Research Technician, Sr.

Nicole Lee, BA
Nicole Lee

Research Technician

Emily Levy, BS
Emily Levy

Research Technician

Sophie Lieberman
Sophie Lieberman

Research Technician

Caroline Lindemans

Postdoctoral Research Fellow

Sydney Lu

Graduate Student

Vanessa Lucey (Hubbard)

Research Technician

Florent Malard, MD, PhD
Florent Malard

Research Fellow

Kate Markey, MBBS, PhD
Kate Markey

Assistant Attending Lv. 1

Anna Mertelsmann
Anna Mertelsmann

Medical Student, University Hospital Eppendorf, Hamburg, Germany

Barbara Morcerf

Administrative Secretary

Christina Muggeo, BA
Christina Muggeo

Administrative Secretary

Stephanie J. Muriglan

Research Technician

Il-Kang Na

Research Fellow

Katherine Nichols
Katherine Nichols

Research Technician

Kanish Patel, BA
Kanish Patel

Project Coordinator

Olaf Penack

Research Fellow

Carmen Perez
Carmen Perez

Radiation Oncology Resident, Research Fellow

Lia Perez

Postdoctoral Research Fellow

Suelen Perobelli, PhD
Suelen Perobelli

Visiting Research Fellow

Kelly Piersanti

Senior Research Technician to Dr. Lia Palomba

Michael R. Pitter, BA
Michael R. Pitter

Research Technician

Hendrik Poeck

Feodor Lynen Scholar for Experienced Researchers (Alexander von Humboldt-Foundation)

Teresa Ramirez-Montagut

Postdoctoral Research Fellow

Lilly Reilly

Assistant to Marcel van den Brink, MD, PhD

Shalee Richardson

Administrative Secretary

Betsy Rojas

Assistant to Marcel van den Brink, MD, PhD

Jimmy A. Rotolo

Research Technician

Raffaella Schiro

Postdoctoral Research Fellow

Cornelius Schmaltz

Postdoctoral Research Fellow

Yusuke Shono

Visiting Investigator

Natalie Singer

Research Technician

Annie Slingerland, BA, Smith College
Annie Slingerland

Research Technician, Sr.

Melody Smith, MD
Melody Smith

Assistant Attending Lv. 1

O. Marsinay Smith, BA
O. Marsinay Smith

Senior Research Assistant

Megan Solberg, BA
Megan Solberg

Senior Project Coordinator

Anna Staffas, PhD
Anna Staffas

Research Fellow

Christoph Stein-Thoeringer

Visiting Investigator

Dave Suh

Research Technician

Mohammed Suhail Chaudhry
Theis Therway

Research Fellow

Jennifer Tsai, MD
Jennifer Tsai

Visiting Investigator

Andrea Tuckett

Research Associate

Jort van der Schans

Graduate Student

Thomas van Huystee

Postdoctoral Research Fellow

Enrico Velardi, PhD
Enrico Velardi

Visiting Investigator

Elisha Waldman

Postdoctoral Research Fellow

Tobias Wertheimer

Graduate Research Assistant

Mallory West

Research Technician

Lucy M. Willis

Research Technician, Graduate Student

Nury Yim

Howard Hughes Medical Institute Medical Research Fellow

Lauren Young

Senior Research Technician

Salma Youssef
Salma Youssef

Research Trainee

Lab Affiliations

Achievements

  • Head of the Division of Hematologic Malignancies at MSKCC (2008 - present)
  • Royal Dutch Academy of Sciences (2020)
  • International Society for Experimental Hematology: Till and McCulloch Lectureship Award (2015)
  • Alan N. Houghton Chair in Immunology at MSKCC (2007)
  • Howard Hughes Physician Scientist Award (1996)

Lab News & Events

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Lab social at Treadwell Park!

US Open

Some of our lab members attending the US Open

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Marcel R. M. van den Brink discloses the following relationships and financial interests:

  • Ceramedix
    Provision of Services
  • DKMS
    Fiduciary Role/Position; Provision of Services
  • Da Volterra
    Provision of Services
  • Garuda Therapeutics
    Provision of Services
  • GlaxoSmithKline
    Provision of Services
  • Juno Therapeutics
    Intellectual Property Rights
  • King Faisal Specialist Hospital & Research Centre
    Provision of Services
  • LyGenesis, Inc.
    Provision of Services
  • MJH Life Sciences
    Provision of Services
  • Notch Therapeutics
    Ownership / Equity Interests; Provision of Services
  • Pluto Immunotherapeutics
    Ownership / Equity Interests; Provision of Services (uncompensated)
  • Priothera Limited
    Provision of Services
  • Rheos Medicines, Inc
    Provision of Services
  • Seres Therapeutics
    Intellectual Property Rights; Ownership / Equity Interests; Provision of Services
  • Smart Immune SAS
    Provision of Services (uncompensated)
  • WindMIL Therapeutics, Inc.
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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