Immunology Program

The Marcel van den Brink Lab

Research

Marcel R. M. van den Brink, MD, PhD

Allogeneic hematopoietic stem cell transplantation (HSCT) is an important therapy for a variety of cancers, including leukemias, lymphomas, and myeloma. Several complications limit its use, including relapse of malignancy, graft-versus-host disease, and prolonged immune depletion caused by the conditioning required for successful transplantation — all of which can lead to increased morbidity and mortality after allo-HSCT. My laboratory studies clinically relevant problems in HSCT and aims to develop novel therapeutic strategies to improve patient outcome.

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Research Projects

van den Brink Lab group photo

Featured News

Success of Bone Marrow Transplants Using Patients’ Own Cells Impacted by Gut Bacteria

Thursday, March 18, 2021

Finding

MSK Study Is the First to Link Microbiota to Dynamics of the Human Immune System

Wednesday, November 25, 2020

Finding

Study in Mice Suggests Lactose in the Diet Feeds Dangerous Gut Bacteria When the Immune System Is Compromised

Friday, November 29, 2019

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Publications

Peled JU, Gomes ALC, Devlin SM, Littmann ER, Taur Y, Sung AD, Weber D, Hashimoto D, Slingerland AE, Slingerland JB, Maloy M, Clurman AG, Stein-Thoeringer CK, Markey KA, Docampo MD, Burgos da Silva M, Khan N, Gessner A, Messina JA, Romero K, Lew MV, Bush A, Bohannon L, Brereton DG, Fontana E, Amoretti LA, Wright RJ, Armijo GK, Shono Y, Sanchez-Escamilla M, Castillo Flores N, Alarcon Tomas A, Lin RJ, Yáñez San Segundo L, Shah GL, Cho C, Scordo M, Politikos I, Hayasaka K, Hasegawa Y, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Jenq RR, Teshima T, Chao NJ, Holler E, Xavier JB, Pamer EG, van den Brink MRM. Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation. N Engl J Med. 2020 Feb 27;382(9):822-834. doi: 10.1056/NEJMoa1900623.

Markey KA, Schluter J, Gomes ALC, Littmann ER, Pickard AJ, Taylor BP, Giardina PA, Weber D, Dai A, Docampo MD, Armijo GK, Slingerland AE, Slingerland JB, Nichols KB, Brereton DG, Clurman AG, Ramos RJ, Rao A, Bush A, Bohannon L, Covington M, Lew MV, Rizzieri DA, Chao N, Maloy M, Cho C, Politikos I, Giralt S, Taur Y, Pamer EG, Holler E, Perales MA, Ponce DM, Devlin SM, Xavier J, Sung AD, Peled JU, Cross JR, van den Brink MRM. The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD. Blood. 2020 Jul 2;136(1):130-136. doi: 10.1182/blood.2019003369.

Stein-Thoeringer CK, Nichols KB, Lazrak A, Docampo MD, Slingerland AE, Slingerland JB, Clurman AG, Armijo G, Gomes ALC, Shono Y, Staffas A, Burgos da Silva M, Devlin SM, Markey KA, Bajic D, Pinedo R, Tsakmaklis A, Littmann ER, Pastore A, Taur Y, Monette S, Arcila ME, Pickard AJ, Maloy M, Wright RJ, Amoretti LA, Fontana E, Pham D, Jamal MA, Weber D, Sung AD, Hashimoto D, Scheid C8, Xavier JB, Messina JA, Romero K, Lew M, Bush A, Bohannon L, Hayasaka K, Hasegawa Y, Vehreschild MJGT, Cross JR, Ponce DM, Perales MA, Giralt SA, Jenq RR, Teshima T1, Holler E, Chao NJ, Pamer EG, Peled JU, van den Brink MRM. Lactose Drives Enterococcus Expansion to Promote Graft-versus-Host Disease. Science. 2019; 366(6469)1143–1149.

Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulos KV, Shieh JH, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM*, Dudakov JA*. Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injuries. Nature Medicine. 2018; 24(2):239-246. PMC5803436

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People

Marcel R. M. van den Brink, MD, PhD

Physician-scientist Marcel R. M. van den Brink studies the immunology of bone marrow transplantation with a particular focus on intestinal microbiome and strategies to enhance thymus and immune reconstitution.
MD, PhD, Universiteit Leiden

vandenbm@mskcc.org: Email Address
646-888-2304: Office Phone
View physician profile: Physician profile

Members

Peter Adintori, MS, RD, CDN — Peter Adintori
Clinical Research Dietitian

Kimon Argyropoulos, MD — Kimon Argyropoulos
Visiting Investigator

Marina Burgos da Silva, MSc, PhD — Marina Burgos da Silva
Research Scholar

Sophia Chen, MD — Sophia Chen
Research Fellow

Annelie Clurman
Clinical Research Specialist

Susan Dewolf, MD — Susan De Wolf
Clinical Fellow

Harold Elias, MD — Harold Elias
Senior Research Scientist

Paul Giardina
Research Project Associate

Leana Harford
Clinical Research Specialist

Pamela Herrera (Hatfield)
Graduate Student

Scott James, MD, PhD — Scott James
Assistant Attending Lv. 1

Nicole Lee, BA — Nicole Lee
Research Technician

Sarah Lindner, MD — Sarah Lindner
Research Fellow

Kate Markey, MBBS, PhD — Kate Markey
Assistant Attending Lv. 1

Oriana Miltiadous, MD — Oriana Miltiadous
Pediatric Hematology/Oncology Clinical Instructor

Chi Nguyen, PhD Candidate — Chi Nguyen
Graduate Student

M. Lia Palomba, MD — M. Lia Palomba
Hematologic Oncologist

Jenny Paredes Sanchez, PhD — Jenny Paredes Sanchez
Research Fellow

Jonathan U. Peled, MD, PhD — Jonathan U. Peled
Assistant Attending

Marissa Peterson
Senior Administrative Assistant

Katarina Piasevoli, Project Coordinator — Katarina Piasevoli
Senior Project Coordinator

Mihika Shah, BS — Mihika Shah
Senior Administrative Assistant

Roni Shouval

Bone Marrow Transplantation Fellow

John Slingerland
Research Project Manager

Melody Smith, MD — Melody Smith
Assistant Attending Lv. 1

Jennifer Tsai, MD — Jennifer Tsai
Visiting Investigator

Lab Alumni

Katya Ahr, BA — Katya Ahr
Administrative Secretary

Onder Alpdogan

Postdoctoral Research Fellow

Stephanie Benardis, BA, BSN — Stephanie Benardis
SKI Administrative Assistant, Senior

Daniel Brereton
Clinical Research Coordinator

Marissa Buchan , MS, RDN, CDN — Marissa Buchan
Clinical Research Dietitian

Kristina Caban, BA — Kristina Caban
SKI Administrative Assistant, Sr.

Nicole DeSimone, Administrative Secretary — Nicole DeSimone
Administrative Assistant

Barbara Du Rocher D'Aguiar Silva

Graduate Student

Jarrod Dudakov, PhD — Jarrod Dudakov
Senior Research Scientist

Melissa Docampo, PhD — Melissa Docampo
Postdoctoral Fellow

Katrina Edmondson

Administrative Secretary

Gabriel Eisenkolb, MD Candidate — Gabriel Eisenkolb
Graduate Research Assistant

Anna Franklin (Keating)

Postdoctoral Research Fellow

Arnab Ghosh

Research Fellow

Antonio Gomes, PhD — Antonio Gomes
Computational Biologist, Sr.

Gabrielle Goldberg

Postdoctoral Research Fellow

Kalliopi Grigoriadou

Postdoctoral Research Fellow

Jeremy Grubin

Research Technician

Sheena Kapoor
SKI Administrative Assistant II

Jens Halm

Postdoctoral Research Fellow

Alan Hanash

Steffen Hartrampf

Research Fellow

Robert R. Jenq, MD — Robert R. Jenq
Assistant Attending, Bone Marrow Transplant

Barry Kappel

Research Technician

Theo Kim

Postdoctoral Research Fellow

Chris King

Research Technician

Aleksandra Kirovski-Petrovic

Postdoctoral Research Fellow

Adam Kochman

Research Technician

Fabiana Kreines, BA — Fabiana Kreines
Research Technician

Amina Lazrak, BS — Amina Lazrak
Research Technician, Sr.

Emily Levy, BS — Emily Levy
Research Technician

Caroline Lindemans
Postdoctoral Research Fellow

Sydney Lu

Graduate Student

Vanessa Lucey (Hubbard)

Research Technician

Florent Malard, MD, PhD — Florent Malard
Research Fellow

Anna Mertelsmann
Medical Student, University Hospital Eppendorf, Hamburg, Germany

Barbara Morcerf

Administrative Secretary

Christina Muggeo, BA — Christina Muggeo
Administrative Secretary

Stephanie J. Muriglan

Research Technician

Il-Kang Na

Research Fellow

Kanish Patel, BA — Kanish Patel
Project Coordinator

Olaf Penack

Research Fellow

Carmen Perez
Radiation Oncology Resident, Research Fellow

Lia Perez

Postdoctoral Research Fellow

Suelen Perobelli, PhD — Suelen Perobelli
Visiting Research Fellow

Kelly Piersanti
Senior Research Technician to Dr. Lia Palomba

Michael R. Pitter, BA — Michael R. Pitter
Research Technician

Hendrik Poeck

Feodor Lynen Scholar for Experienced Researchers (Alexander von Humboldt-Foundation)

Teresa Ramirez-Montagut

Postdoctoral Research Fellow

Lilly Reilly

Assistant to Marcel van den Brink, MD, PhD

Shalee Richardson

Administrative Secretary

Betsy Rojas

Assistant to Marcel van den Brink, MD, PhD

Jimmy A. Rotolo

Research Technician

Raffaella Schiro

Postdoctoral Research Fellow

Cornelius Schmaltz

Postdoctoral Research Fellow

Annie Slingerland, BA, Smith College — Annie Slingerland
Research Technician, Sr.

O. Marsinay Smith, BA — O. Marsinay Smith
Senior Research Assistant

Megan Solberg, BA — Megan Solberg
Senior Project Coordinator

Anna Staffas, PhD — Anna Staffas
Research Fellow

Christoph Stein-Thoeringer
Visiting Investigator

Dave Suh

Research Technician

Theis Therway

Research Fellow

Andrea Tuckett

Research Associate

Thomas van Huystee

Postdoctoral Research Fellow

Enrico Velardi, PhD — Enrico Velardi
Visiting Investigator

Elisha Waldman

Postdoctoral Research Fellow

Tobias Wertheimer
Graduate Research Assistant

Lucy M. Willis

Research Technician, Graduate Student

Nury Yim
Howard Hughes Medical Institute Medical Research Fellow

Lab Affilations

Achievements

Head of the Division of Hematologic Malignancies at MSKCC (2008 - present)
Royal Dutch Academy of Sciences (2020)
International Society for Experimental Hematology: Till and McCulloch Lectureship Award (2015)
Alan N. Houghton Chair in Immunology at MSKCC (2007)
Howard Hughes Physician Scientist Award (1996)

Lab News & Events

Tweets by @@vandenBrinkLab?lang=en

“Wear White Day” for Cancer Immunotherapy Month - 2019

Hiking around Mohonk Lake at the annual Immunology retreat - 2019

Get in Touch

vandenbm@mskcc.org

Lab Head Email
646-888-2304

Office Phone
646-422-0452

Office Fax
646-888-2317

Lab Phone
646-422-0452

Lab Fax
Follow Marcel van den Brink on Twitter!
Follow the van den Brink lab on Twitter!

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Marcel R. M. van den Brink discloses the following relationships and financial interests:

CRYOSTEM
Provision of Services (uncompensated)
DKMS
Fiduciary Role/Position; Provision of Services
Duke-NUS Medical School
Provision of Services
European Federation for Immunogenetics (EFI)
Provision of Services (uncompensated)
European Society for Blood and Marrow Transplantation (EBMT)
Provision of Services (uncompensated)
Falk Foundation e.V.
Provision of Services (uncompensated)
Fred Hutchinson Cancer Research Center
Provision of Services (uncompensated)
French National Research Agency
Provision of Services (uncompensated)
Juno Therapeutics
Intellectual Property Rights
King Faisal Specialist Hospital & Research Centre
Provision of Services

Lille University Hospital (Chu De Lille)
Provision of Services (uncompensated)
Magenta
Provision of Services (uncompensated)
Ospedale Pediatrico Bambino Gesù
Provision of Services (uncompensated)
Parker Institute for Cancer Immunotherapy
Provision of Services (uncompensated)
Seres Therapeutics
Intellectual Property Rights; Ownership / Equity Interests; Provision of Services
Technical University of Denmark
Provision of Services
The Korean Society of Blood and Marrow Transplantation (KSBMT)
Provision of Services (uncompensated)
The Meredith A. Cowden Foundation
Provision of Services
University of Copenhagen
Provision of Services (uncompensated)
Xinqiao Hospital
Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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