Allogeneic hematopoietic stem cell transplantation (HSCT) is an important therapy for a variety of cancers, including leukemias, lymphomas, and myeloma. Several complications limit its use, including relapse of malignancy, graft-versus-host disease, and prolonged immune depletion caused by the conditioning required for successful transplantation — all of which can lead to increased morbidity and mortality after allo-HSCT. My laboratory studies clinically relevant problems in HSCT and aims to develop novel therapeutic strategies to improve patient outcome.
Marcel R. M. van den Brink, MD, PhD
Professor
Research Focus
Physician-scientist Marcel R. M. van den Brink studies the immunology of bone marrow transplantation with a particular focus on intestinal microbiome and strategies to enhance thymus and immune reconstitution.Education
MD, PhD, Universiteit Leiden- Office Phone: 646-888-2304
- Office Fax: 646-422-0452
- Lab Phone: 646-888-2317
- Lab Fax: 646-422-0452
Lab Members
Lab Head
Clinical Research Dietitian
Research Fellow
Visiting Investigator
Research Technician
Clinical Research Coordinator
Research Scholar
Research Fellow
Clinical Research Specialist
Computational Biologist I
Clinical Fellow
Graduate Student
Research Technician
Senior Research Scientist
Research Technician
Research Project Associate
Computational Biologist, Sr.
Graduate Student
Research Scholar
Assistant Attending Lv. 1
SKI Administrative Assistant II
Research Fellow
Research Technician
Research Fellow
Assistant Attending Lv. 1
Pediatric Hematology Oncology fellow
Graduate Student
Graduate Student
Research Technician
Hematologic Oncologist
Assistant Attending
Administrative Assistant
Project Coordinator
Administrative Assistant
Visiting Investigator
Research Project Manager
Assistant Attending Lv. 1
Visiting Investigator
- Stein-Thoeringer CK, Nichols KB, Lazrak A, Docampo MD, Slingerland AE, Slingerland JB, Clurman AG, Armijo G, Gomes ALC, Shono Y, Staffas A, Burgos da Silva M, Devlin SM, Markey KA, Bajic D, Pinedo R, Tsakmaklis A, Littmann ER, Pastore A, Taur Y, Monette S, Arcila ME, Pickard AJ, Maloy M, Wright RJ, Amoretti LA, Fontana E, Pham D, Jamal MA, Weber D, Sung AD, Hashimoto D, Scheid C8, Xavier JB, Messina JA, Romero K, Lew M, Bush A, Bohannon L, Hayasaka K, Hasegawa Y, Vehreschild MJGT, Cross JR, Ponce DM, Perales MA, Giralt SA, Jenq RR, Teshima T1, Holler E, Chao NJ, Pamer EG, Peled JU, van den Brink MRM. Lactose Drives Enterococcus Expansion to Promote Graft-versus-Host Disease. Science. 2019; 366(6469):1143–1149.
- Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulos KV, Shieh JH, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM*, Dudakov JA*. Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injuries. Nature Medicine. 2018; 24(2):239-246. PMC5803436
