Marcel R. M. van den Brink: Publications

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Shouval R, Fein JA, Cho C, Avecilla S, Ruiz JD, Alarcon Tomas A, Sanchez-Escamilla M, Castillo Flores N, Yanez San Segundo L, Barker JN, Dahi PB, Giralt S, Geyer A, Gyurkocza B, Jakubowski AA, Lin RJ, O’Reilly RJ, Papadopoulos EB, Politikos I, Ponce DM, Sauter CS, Scordo M, Shaffer B, Shah G, Sullivan JP, Tamari R, van den Brink MRMR, Young JW, Nagler A, Devlin SM, Shimoni A, Perales MA. The Simplified Comorbidity Index (SCI) - a new tool for prediction of non-relapse mortality in allogeneic HCT. Blood Adv. 2021 Sep 10:bloodadvances.2021004319. doi: 10.1182/bloodadvances.2021004319. Epub ahead of print. PMID: 34507354.

Van Lier YF, Van den Brink MRM, Hazenberg MD, Markey KA. The post-hematopoietic cell transplantation microbiome: relationships with transplant outcome and potential therapeutic targets. Haematologica. 2021 Aug 1;106(8):2042-2053. doi: 10.3324/haematol.2020.270835. PMID: 33882637; PMCID: PMC8327718.

Nawas MT, Shah GL, Feldman DR, Ruiz JD, Robilotti EV, Aslam AA, Dundas M, Kamboj M, Barker JN, Cho C, Chung DJ, Dahi PB, Giralt SA, Gyurkocza B, Lahoud OB, Landau HJ, Lin RJ, Mailankody S, Palomba ML, Papadopoulos EB, Politikos I, Ponce DM, Sauter CS, Shaffer BC, Scordo M, van den Brink MRM, Perales MA, Tamari R. Cellular Therapy During COVID-19: Lessons Learned and Preparing for Subsequent Waves. Transplant Cell Ther. 2021 May;27(5):438.e1-438.e6. doi: 10.1016/j.jtct.2021.02.011. Epub 2021 Feb 14. PMID: 33728417; PMCID: PMC7952254.

Giri VK, Kegerreis KG, Ren Y, Bohannon LM, Lobaugh-Jin E, Messina JA, Matthews A, Mowery YM, Sito E, Lassiter M, Saullo JL, Jung SH, Ma L, Greenberg M, Andermann TM, van den Brink MRM, Peled JU, Gomes ALC, Choi T, Gasparetto CJ, Horwitz ME, Long GD, Lopez RD, Rizzieri DA, Sarantopoulos S, Chao NJ, Allen DH, Sung AD. Chlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation. Transplant Cell Ther. 2021 Mar;27(3):262.e1-262.e11. doi: 10.1016/j.jtct.2021.01.004. Epub 2021 Jan 7. PMID: 33781532; PMCID: PMC8010223.

Liao C, Taylor BP, Ceccarani C, Fontana E, Amoretti LA, Wright RJ, Gomes ALC, Peled JU, Taur Y, Perales MA, van den Brink MRM, Littmann E, Pamer EG, Schluter J, Xavier JB. Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients. Sci Data. 2021 Mar 2;8(1):71. doi: 10.1038/s41597-021-00860-8. Erratum in: Sci Data. 2021 Apr 23;8(1):119. PMID: 33654104; PMCID: PMC7925583.

Khan N, Lindner S, Gomes ALC, Devlin SM, Shah GL, Sung AD, Sauter CS, Landau HJ, Dahi PB, Perales MA, Chung DJ, Lesokhin AM, Dai A, Clurman A, Slingerland JB, Slingerland AE, Brereton DG, Giardina PA, Maloy M, Armijo GK, Rondon-Clavo C, Fontana E, Bohannon L, Ramalingam S, Bush AT, Lew MV, Messina JA, Littmann E, Taur Y, Jenq RR, Chao NJ, Giralt S, Markey KA, Pamer EG, van den Brink MRM, Peled JU. Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study. Blood. 2021 Mar 18;137(11):1527-1537. doi: 10.1182/blood.2020006923. PMID: 33512409; PMCID: PMC7976512.

Song Q, Wang X, Wu X, Kang TH, Qin H, Zhao D, Jenq RR, van den Brink MRM, Riggs AD, Martin PJ, Chen YZ, Zeng D. IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice. Nat Commun. 2021 Feb 5;12(1):805. doi: 10.1038/s41467-021-21133-3.

Schluter J, Peled JU, Taylor BP, Markey KA, Smith M, Taur Y, Niehus R, Staffas A, Dai A, Fontana E, Amoretti LA, Wright RJ, Morjaria S, Fenelus M, Pessin MS, Chao NJ, Lew M, Bohannon L, Bush A, Sung AD, Hohl TM, Perales MA, van den Brink MRM, Xavier JB. The gut microbiota is associated with immune cell dynamics in humans. Nature. 2020 Dec;588(7837):303-307. doi: 10.1038/s41586-020-2971-8. Epub 2020 Nov 25.

Argyropoulos KV, Pulitzer M, Maura F, Mohanty A, Mondello P, Horwitz SM, Myskowski P, Moskowitz A, Dogan A, Querfeld C, Rapaport F, Siakantaris M, Louis PC, Galasso N, van den Brink MRM, Palomba ML. Targeted genomic analysis of cutaneous T cell lymphomas identifies a subset with aggressive clinicopathological features. Blood Cancer J. 2020 Nov 9;10(11):116. doi: 10.1038/s41408-020-00380-5.

Guo H, Chou WC, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM, Sung AD, Chao NJ, Peled JU, Gomes ALC, van den Brink MRM, French MJ, Macintyre AN, Sempowski GD, Tan X, Sartor RB, Lu K, Ting JPY. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020 Oct 30;370(6516):eaay9097. doi: 10.1126/science.aay9097.

Velardi E, Tsai JJ, van den Brink MRM. T cell regeneration after immunological injury. Nat Rev Immunol. 2020 Oct 23:1–15. doi: 10.1038/s41577-020-00457-z. Epub ahead of print.

Markey KA, Schluter J, Gomes ALC, Littmann ER, Pickard AJ, Taylor BP, Giardina PA, Weber D, Dai A, Docampo MD, Armijo GK, Slingerland AE, Slingerland JB, Nichols KB, Brereton DG, Clurman AG, Ramos RJ, Rao A, Bush A, Bohannon L, Covington M, Lew MV, Rizzieri DA, Chao N, Maloy M, Cho C, Politikos I, Giralt S, Taur Y, Pamer EG, Holler E, Perales MA, Ponce DM, Devlin SM, Xavier J, Sung AD, Peled JU, Cross JR, van den Brink MRM. The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD. Blood. 2020 Jul 2;136(1):130-136. doi: 10.1182/blood.2019003369.

Peled JU, Gomes ALC, Devlin SM, Littmann ER, Taur Y, Sung AD, Weber D, Hashimoto D, Slingerland AE, Slingerland JB, Maloy M, Clurman AG, Stein-Thoeringer CK, Markey KA, Docampo MD, Burgos da Silva M, Khan N, Gessner A, Messina JA, Romero K, Lew MV, Bush A, Bohannon L, Brereton DG, Fontana E, Amoretti LA, Wright RJ, Armijo GK, Shono Y, Sanchez-Escamilla M, Castillo Flores N, Alarcon Tomas A, Lin RJ, Yáñez San Segundo L, Shah GL, Cho C, Scordo M, Politikos I, Hayasaka K, Hasegawa Y, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Jenq RR, Teshima T, Chao NJ, Holler E, Xavier JB, Pamer EG, van den Brink MRM. Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation. N Engl J Med. 2020 Feb 27;382(9):822-834. doi: 10.1056/NEJMoa1900623.

Stoma I, Littmann ER, Peled JU, Giralt S, van den Brink MRM, Pamer EG, Taur Y. Compositional flux within the intestinal microbiota and risk for bloodstream infection with gram-negative bacteria. Clin Infect Dis. 2020 Jan 24:ciaa068. doi: 10.1093/cid/ciaa068. 

Politikos I, Lavery JA, Hilden P, Cho C, Borrill T, Maloy MA, Giralt SA, van den Brink MRM, Perales MA, Barker JN. Robust CD4+ T-cell recovery in adults transplanted with cord blood and no antithymocyte globulin. Blood Advances. 2020 Jan 14;4(1):191-202. doi: 10.1182/bloodadvances.2019000836. PMCID: PMC6960461.

Stein-Thoeringer CK, Nichols KB, Lazrak A, Docampo MD, Slingerland AE, Slingerland JB, Clurman AG, Armijo G, Gomes ALC, Shono Y, Staffas A, Burgos da Silva M, Devlin SM, Markey KA, Bajic D, Pinedo R, Tsakmaklis A, Littmann ER, Pastore A, Taur Y, Monette S, Arcila ME, Pickard AJ, Maloy M, Wright RJ, Amoretti LA, Fontana E, Pham D, Jamal MA, Weber D, Sung AD, Hashimoto D, Scheid C8, Xavier JB, Messina JA, Romero K, Lew M, Bush A, Bohannon L, Hayasaka K, Hasegawa Y, Vehreschild MJGT, Cross JR, Ponce DM, Perales MA, Giralt SA, Jenq RR, Teshima T1, Holler E, Chao NJ, Pamer EG, Peled JU, van den Brink MRM. Lactose Drives Enterococcus Expansion to Promote Graft-versus-Host Disease. Science. 2019; 366(6469)1143–1149.

Staffas A, Burgos da Silva M, Slingerland AE, Lazrak A, Bare CJ, Holman CD, Docampo MD, Shono Y, Durham B, Pickard AJ, Cross JR, Stein-Thoeringer C, Velardi E, Tsai JJ, Jahn J, Jay H, Lieberman S, Smith OM, Pamer EG, Peled JU, Cohen DE, Jenq RR, van den Brink MRM. Nutritional support from the intestinal microbiota improves hematopoietic reconstitution after bone marrow transplantation in mice. Cell Host & Microbe. 2018; 23(4):447-457. (commentary in Science 2018; 360(6387):394-395 and in Cell Host & Microbe 2018; 23(4):423-424.)  PMC5897172.

Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulos KV, Shieh JH, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM*, Dudakov JA*. Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injuries. Nature Medicine. 2018; 24(2):239-246. PMC5803436 [PMID: 29309056]
*authors contributed equally

Tsai JJ, Velardi E, Shono Y, Argyropoulos K, Holland AM, Smith OM, Yim NL, Rao UK, Kreines FM, Lieberman SR, Young LF, Lazrak A, Youssef S, Fu YY, Liu C, Lezcano C, Murphy GF, Na IK, Jenq RR, Hanash AM, Dudakov JA, van den Brink MRM. Nrf2 regulates CD4 T cell-induced acute graft-versus-host disease. Blood. 2018; doi: 10.1182/blood-2017-10-812941.

Wertheimer T, Velardi E, Tsai J, Cooper K, Xiao S, Kloss CC, Ottmuller KJ, Mokthari Z, Brede C, deRoos P, Kinsella S, Palikuqi B, Ginsberg M, Young LF, Kreines F, Lieberman SR, Lazrak A, Guo P, Malard F, Smith OM, Shono Y, Jenq RR, Hanash AM, Nolan DJ, Butler JM, Beilhack A, Manley NR, Rafii S, Dudakov JA, and van den Brink MRM. Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Science Immunology. 2018; 3(19): pii: eaal2736. PMC5795617

Matsuzawa-Ishimoto Y*, Shono Y*, Gomez LE, Hubbard-Lucey VM, Cammer M, Neil J, Dewan MZ, Lieberman SR, Jay HV, Lazrak A, Liu C, Ding Y, van den Brink MRM*, Cadwell K*. Autophagy Protein ATG16L1 Prevents Necroptosis in the Intestinal Epithelium. J Exp Med. 2017; 214(12):3687-3705. PMC5716041 [PMID: 29089374]
*authors contributed equally

Ghosh A, Smith M, James SE, Davila ML, Velardi E, Argyropoulos KV, Gunset G, Perna F, Kreines FM, Levy ER, Lieberman S, Jay HV, Tuckett AZ, Zakrzewski JL, Tan L, Young LF, Takvorian K, Dudakov JA, Janq RR, Hanash AM, Motta ACF, Murphy GF, Liu C, Schietinger A, Sadelain M, van den Brink MRM. Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity. Nature Medicine. 2017. 23(2):242-249. (commentary in Nature Medicine 2017; 23(2):147-148.) PMC5528161

Peled JU, Devlin SM, Staffas A, Lumish M, Khanin R, Littmann ER, Ling L, Kosuri K, Maloy M, Slingerland JB, Ahr KF, Porosnicu-Rodriguez KA, Shono Y, Slingerland A, Docampo MD, Sung AD, Weber D, Alousi AM, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Taur Y, Pamer EG, Jenq RR*, van den Brink MRM*. Intestinal microbiota and relapse after hematopoietic-cell transplantation. J Clin Oncol. 2017; 35(15): 1650-1659. PMC5455763. [PMID: 28296584]
*authors contributed equally

Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR, Jay HV, Ahr KF, Rodriguez KAP, Xu K, Calarfiore M, Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA, Hanash AM, Gyurkocza B, Murphy GF, Gomes CG, Liu C, Moss EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink MRM*, Jenq RR*. Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice. Sci Transl Med. 2016; 8(339): 339ra71. PMC4991773. [PMID: 27194729]
*authors contributed equally

Lindemans CA, Calafiore M, Mertelsmann AM, O’Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O’Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM*, Hanash AM.* Interleukin-22 Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration. Nature. 2015; 528(7583):560-4. PMC4720437 [PMID: 26649819]
*authors contributed equally

Reviews, Editorials, & Forums

Velardi E, Tsai JJ, van den Brink MRM. T cell regeneration after immunological injury. Nat Rev Immunol. 2021 May;21(5):277-291. doi: 10.1038/s41577-020-00457-z. Epub 2020 Oct 23. PMID: 33097917; PMCID: PMC7583557.

Van Lier YF, Van den Brink MRM, Hazenberg MD, Markey KA. The post-hematopoietic cell transplantation microbiome: relationships with transplant outcome and potential therapeutic targets. Haematologica. 2021 Apr 22. doi: 10.3324/haematol.2020.270835. Epub ahead of print. PMID: 33882637.

Lin RJ, Elias HK, van den Brink MRM. Immune Reconstitution in the Aging Host: Opportunities for Mechanism-Based Therapy in Allogeneic Hematopoietic Cell Transplantation. Front Immunol. 2021 Apr 19;12:674093. doi: 10.3389/fimmu.2021.674093. [PMID: 33953731]; PMCID: PMC8089387.

Elias HK, Van den Brink MRM. New option for improving hematological recovery: suppression of luteinizing hormone. Haematologica. 2021 Apr 1;106(4):929-931. doi: 10.3324/haematol.2020.274969. PMID: 33297666; PMCID: PMC8017809.

Andrlová H, van den Brink MRM, Markey KA. An Unconventional View of T Cell Reconstitution After Allogeneic Hematopoietic Cell Transplantation. Front Oncol. 2021 Feb 18;10:608923. doi: 10.3389/fonc.2020.608923. [PMID: 33680931]; PMCID: PMC7930482.

Markey KA, van den Brink MRM, Peled JU.. Therapeutics Targeting the Gut Microbiome: Rigorous Pipelines for Drug Development. Cell Host Microbe. 2020;27(2):169-172. doi:10.1016/j.chom.2020.01.022. [PMID: 32053786]

Shono Y, van den Brink MRM. Gut microbiota injury in allogeneic hematopoietic stem cell transplantation. Nature Review Cancer. 2018; doi: 10.1038/nrc.2018.10.

Dudakov JA, Hanash AM, van den Brink MRM. Interleukin-22: Immunobiology and Pathology. Annu Rev Immunol. 2015: 33:747-785. PMC4407497

View a full listing of Marcel R. M. van den Brink: Publications’ journal articles.