Aliaksandra Radsizheuskaya

Postdoctoral Fellow

Aliaksandra Radsizheuskaya

Education

BS, University of Edinburgh, UK; PhD, University of Cambridge, UK

Alex is originally from Belarus. Her PhD was focused on studying the molecular mechanisms of nuclear reprogramming in the laboratory of Dr José Silva at the Cambridge Stem Cell Institute. At the end of 2014, she joined the laboratory of Kristian Helin at the Biotech Research and Innovation Center in Copenhagen. In December 2018, she joined his lab at the MSKCC.

Fellowships
EMBO Long-Term Postdoctoral Fellowship
​​​​Marie Skłodowska-Curie Individual Fellowship

Publications

Radzisheuskaya A, Shlyueva D, Müller I and Helin K. (2016) Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Nucleic Acids Res. 44(18): e141.

Pedersen MT, Kooistra SM, Radzisheuskaya A, Laugesen A, Johansen JV, Hayward DG, Nilsson J, Agger K and Helin K. (2016) Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self- renewal and early development. EMBO J. 35(14): 1550-64.

Radzisheuskaya A, Chia G le B, dos Santos RL, Theunissen TW, Castro LF, Nichols J, Silva JC. (2013) A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages. Nat Cell Biol. 15(6):579-90.

Pasque V*, Radzisheuskaya A*, Gillich A, Halley-Stott RP, Panamarova M, Zernicka-Goetz M, Surani MA, Silva JC. (2012) Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency. J Cell Sci. 125(Pt 24):6094-104.