Project description:
My research focuses on allogeneic hematopoietic stem cell transplantation (Allo-HSCT) and hematologic diseases in the clinic, as well as on biological research of transplantation immunity and mechanistic research on the pathogenesis and resistance of acute leukemia.
The van den Brink lab has previously shown that the intestinal microbial composition has an important influence in graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL). In line with this, my research focuses on how the microbiota and mucosal immunity affect the outcomes of Allo-HSCT. Our aim is to develop therapeutic strategies to regulate the gut microbiota to decrease GVHD and strengthen GVL after transplant.
Grants/Awards/Highlights:
2012, 2015, 2019, 2022 National Natural Science Foundation of China as PI ( 81100387, 81470309，81870136，82170141)
2022 Key Project of Natural Science Foundation of Zhejiang Province as PI (LXZ22H080001)
2019 “Hundred Talents Program (Clinical Medicine)” of Zhejiang University
2019 Best Abstract Awards of Annual Meeting of Asian-Pacific Bone Marrow Transplantation Group
2018 The second level of Zhejiang province “151 Talents Project”.
2013, European Society for Blood and Marrow Transplantation (EBMT) Travel grant.
Education:
PhD, MD in Hematology. Zhejiang University, Zhejiang, China. 2013
Medical Master Degree. Southern Medical University, Guangzhou, China. 2003
Employment:
2018 – Present: Hematology Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
2022-Present: Visiting Scholar of VDB Lab
Publications:
https://pubmed.ncbi.nlm.nih.gov/?term=Haowen%20Xiao