Structural Biology Program
The Nikola Pavletich Lab
Our research group is interested in understanding, at the structural and mechanistic levels, the maintenance of genomic integrity and the control of cell growth, both of which figure prominently in cancer. In the area of growth control, our recent work is focused on the mTOR pathway that controls multiple aspects of cell growth and homeostasis. Our work on genomic integrity ranges from the Fanconi Anemia pathway, which responds to DNA interstrand crosslinks, to the ATR and ATM checkpoint kinases that coordinate the cell’s response to replication stress and DNA double-strand breaks, respectively. Common to these genomic integrity pathways is eventual repair by homologous recombination, a process that has been a longstanding focus of our research.
Yang, H., Rudge, D.G., Koos, J.D., Vaidialingam, B., Yang, H.J. & Pavletich, N.P. mTOR kinase structure, mechanism and regulation. Nature 497, 217-223 (2013).
Wang, R., Persky, N., Yoo, B., Ouerfelli, O., Smogorzewska, A., Elledge, S. J. & Pavletich, N.P. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science 346, 1127-30 (2014).
Zhou, C., Pourmal, S. & Pavletich, N. P. Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. eLife 4:e09832 (2015).
Yang, H., Jiang, X., Li, B., Yang, H.J., Miller, M., Yang, A., Dhar, A. & Pavletich, N.P. Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature 552, 368-373 (2017).
Nikola P. Pavletich, PhD
- The Pavletich laboratory studies the structural biology of pathways that control cell growth and maintain the integrity of the genome.
- PhD, Johns Hopkins University
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Nikola P. Pavletich discloses the following relationships and financial interests:
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