Developmental Biology Program

The Peter Besmer Lab

Research

Pictured: Peter Besmer
Peter Besmer, PhD
Emeritus

The objective of our research is to investigate the mechanisms by which receptor tyrosine kinases produce cellular responses in vitro in cell systems and in vivo in mice. As a model, the Kit receptor tyrosine kinase and its agonist, the membrane growth factor Kit-ligand (KL), are being studied. Phenotypes of mice with mutations in the genes for the Kit receptor tyrosine kinase and its ligand KL imply roles in gametogenesis, hematopoiesis, and melanogenesis. Based on mutant phenotypes in distinctive cell compartments during embryogenesis and in the postnatal animal, the cellular responses mediated by the Kit receptor are quite diverse and include cell proliferation, cell survival, cell adhesion, cell migration, secretion of mediators, cell differentiation, and other postmitotic functions.

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Pictured: Peter Besmer Lab group photo

People

Pictured: Peter Besmer

Peter Besmer, PhD

Emeritus

  • The Peter Besmer laboratory focuses on normal and oncogenic receptor tyrosine kinase signaling in vitro and in vivo in mice.
  • Dr. sc. nat., Eidg. Technische Hochschule Zurich
Lab Affilations

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