Cell Biology Program

The Raju Chaganti Lab

Research

Raju Chaganti, PhD

Emeritus

The goal of my research program at the Sloan Kettering Institute over the past three decades plus has been the understanding of the natural history of genomic instability in cancer cells and its implication to clinical behavior of tumors on the one hand, and to normal cellular developmental pathways on the other. Over this time period, the tools to identify, measure, and analyze the mechanisms of genomic instability have evolved remarkably.

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At Work: Geneticist Raju Chaganti

Publications

Chaganti, R.S.K., and Nanjangud, G. Cytogenetics of lymphoma. In: Non-Hodgkin’s lymphomas (Mauch, P.M., Armitage, J.O., Coiffier, B., and Dalla-Favera, R., Harris, N.L., eds.) Lippincott, Williams & Wilkins, Baltimore, pp809-824, 2003.

Pasqualucci, L., Migliazza, A., Chaganti, R.S.K., Ye, H. B., and Dalla-Favera, R. Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Blood 101: 2914-2923, 2003.

Teruya-Feldstein, J., Donnelly, G., Goy, A., Hegde, A., Nanjangud, G., Qin, J., Thaler, H., Gillies, F., Dyomin, V.G., Lloyd, K.O., Zelenetz, A.D., Houldsworth, J., and Chaganti, R.S.K. MUC-1 mucin expression correlates with advanced stage disease, adverse event-free and overall survival in diffuse large B-cell lymphoma. Appl. Immunohistochem. Mol. Morph. 11:28-32, 2003.

Houldsworth, J., Olshen, A.B., Cattoretti, G., Donnelly, G.B., Teruya-Feldstein, J., Qin, J., Palanisamy, N., Shen, Y., Dyomina, K., Petlakh, M., Pan, Q., Zelenetz, A.D., and Chaganti, R.S.K. Relationship between REL amplification, REL function, and clinical and biological feaures of diffuse large B-cell lymphoma. Blood. 103: 1862-1868, 2004.

Koul, S., McKiernan, J.M., Narayan, G., Houldsworth, J., Bacik, J., Dobrzynski, D.L., Assad, A.M., Manshukani, M., Reuter, V.E., Bosl, G.J., Chaganti, R.S.K., and Murty, V.V.V.S. Role of promoter hypermethylation in cisplatin treatment response of male germ cell tumors. Mol. Cancer 3:16.

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People

Raju Chaganti, PhD

Emeritus

Geneticist Raju Chaganti studies genomic instability in cancer cells and its implications for clinical behavior of tumors and normal cellular developmental pathways.
PhD, Harvard University