Baggiolini A+, Callahan SJ+, Montal E, Weiss JM, Trieu T, Tagore MM, Tischfield SE, Walsh RM, Suresh S, Fan Y, Campbell NR, Perlee SC, Saurat N, Hunter MV, Simon-Vermot T, Huang TH, Ma Y, Hollmann T, Tickoo SK, Taylor BS, Khurana E, Koche RP, Studer L*, White RM* (2021). +co-authors, *co-corresponding authors. Developmental chromatin programs determine oncogenic competence in melanoma. Science 373 (1104): abc1048. PMCID pending.
Weiss JM, Hunter MV, Tagore M, Ma Y, Misale S, Simon-Vermot T, Campbell NR, Newell F, Wilmott JS, Johansson PA, Thompson JF, Long GV, Pearson JV, Mann GJ, Scolyer RA, Waddell N, Montal ED, Huang T, Jonsson P, Donoghue MTA, Harris CC, Taylor BS, Ariyan CE, Solit DB, Wolchok JD, Merghoub T, Rosen N, Lezcano-Lopez C, Hayward NK, White RM (2021). Anatomic position determines oncogenic specificity in melanoma. in revision, available at: https://www.biorxiv.org/content/10.1101/2020.11.14.383083v1
Campbell NR, Rao A, Hunter MV, Sznurkowska MK, Briker L, Zhang M, Baron M, Heilman S, Deforet M, Kenny C, Ferretti LP, Huang TH, Perlee SC, Garg M, Nsengimana J, Saini M, Montal E, Tagore M, Newton-Bishop J, Middleton MR, Corrie P, Adams DJ, Rabbie R, Aceto N, Levesque MP, Cornell RA, Yanai I, Xavier JB*, White RM* (2021). *co-corresponding authors. Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma. Developmental Cell, 2021 Sep 13:S1534-5807(21)00677-8
Hunter MV+, Moncada R+, Weiss JM, Yanai I*, White RM* (2021). +co-authors, *co-corresponding authors. Spatial transcriptomics reveals the architecture of the tumor/microenvironment interface, Nature Communications, in press, available at https://www.biorxiv.org/content/10.1101/2020.11.05.368753v1
Lumaqin D+, Johns E+, Weiss JM, Montal E, Ooladipupo O, Abuhashem A, White RM. An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish. +co-authors. 2020, in revision, available at https://www.biorxiv.org/content/10.1101/2020.11.09.375667v1
Baron M, Tagore M, Hunter MV, Kim IS, Moncada R, Yan Y, Campbell NR, White RM*, Yanai I*. The Stress-Like Cancer Cell State Is a Consistent Component of Tumorigenesis. *co-corresponding authors. Cell Systems, 2020, Sep 5:S2405-4712(20)30329.
Cederquist G, Tchieu J, Callahan SJ, Ramnarine K, Ryan S, Rittenhouse C, Zeltner N, Chung SY, Zhou T, Chen S , White RM, Tomishima M, Zhang C, Betel D, Studer L. A multiplex human pluripotent stem cell platform defines molecular and functional subtypes of autism. Cell Stem Cell, 2020 Jul 2;27(1):35-49.e6
Temprine K, Langdon EM, Mehta K, Clapp A, White RM. Regulation of the error-prone DNA polymerase polκ by oncogenic signaling and its contribution to drug resistance. Science Signaling, 2020 Apr 28;13(629)
D’Agati G, Cabello EM, Frontzek K, Rushing EJ, Klemm R, Robinson MD, White RM, Mosimann C, Burger A. Active Receptor Tyrosine Kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish. Disease Models and Mechanisms, 2019 Jul 16;12(7)
Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM, Aguirre-Ghiso JA, Heymach JV, Lu KP, Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S. An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. Nature Cell Biology 2019 Feb;21(2):203-213
Zhang M, Martino JSD, Bowman RL, Campbell NR, Baksh SC, Simon-Vermot T, Kim IS, Haldeman P, Mondal C, Yong-Gonzales V, Abu-Akeel M, Merghoub T, Jones DR, Zhu XG, Arora A, Ariyan CE, Birsoy K, Wolchok JD, Panageas KS, Hollmann T, Bravo-Cordero JJ, White RM. Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins. Cancer Discovery 2018 Aug;8(8):1006-1025
Zhang YM, Zimmer MA, Guardia T, Callahan SJ, Mondal C, Di Martino J, Takagi T, Fennell M, Garippa R, Campbell NR, Bravo-Cordero JJ, White RM. Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Developmental Cell. 2018 Jun 4;45(5):580-594
Callahan SJ, Tepan S, Zhang YM, Linday H, Burger A, Campbell NR, Kim IS, Hollmann TJ, Studer L, Mosimann C, White RM. Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). Disease Models and Mechanisms, 2018 Sep 27;11(9)
Pavlova NN, Hui S, Ghergurovich JM, Fan J, Intlekofer AM, White RM, Rabinowitz JD, Thompson CB, Zhang J. As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. Cell Metabolism 2018 Jan 10. pii: S1550-4131(17)30716-7.
D’Agati G, Beltre R, Sessa AK, Burger A, Zhou Y, Mosimann C, White RM. A defect in the mitochondrial protein mpv17 underlies the transparent casper zebrafish. Developmental Biology, 2017 Jul 28. (17)30373-1
Kim IS, Heilmann S, Kansler ER, Zhang Y, Zimmer M, Ratnakumar K, Bowman RL, Simon-Vermot T, Fennell M, Garippa R, Lu L, Lee W, Hollmann, Xavier JB, White RM. Microenvironment-derived factors driving metastatic plasticity in melanoma. Nature Communications, 2017 Feb 9;8:14343
Kansler ER, Verma A, Langdon E, Simon-Vermot T, Yin A, Lee W, Attiyeh M, Elemento O, White RM. Melanoma genome evolution across species. BMC Genomics, 2017 Feb 7;18(1):136.
Wojciechowska S, van Rooijen E, Ceol C, Patton EE, White RM. Generation and analysis of zebrafish melanoma models. Methods Cell Biol. 2016;134:531-49.
Tan JL, Fogley RD, Ablain J, Flynn RA, Yang S, Santi-Andre V, Fan ZP, Do BT, Santoriello C, Laga A, Fujinaga K, Gree CB, Kim YJ, Bothmer A, Brogie JE, van Rooijen E, Hagedorn EJ, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asra JM, Chang HY, Young RA, Zon LI. Nucleotide stress induction of HEXIM1 suppresses melanoma by modulating cancer cell-specific gene transcription. Molecular Cell, 2016 Apr 7;62(1):34-46.
Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas A, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn E, Ciarlo C, White RM, Matos D, Puller A-C, Santoriello C, Liao E, Young RA, and Zon LI. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science, 2016 Jan 29;351(6272).
Heilmann S, Ratnakumar K, Langdon EM, Kansler Er, Kim IS, Campbell NR, Perry EB, McMahon AJ, Kaufman CK, van Rooijen E, Lee W, Iacobuzio-Donahue CA, Hynes RO, Zon LI, Xavier JB, White RM. A quantitative system for studying metastasis using transparent zebrafish. Cancer Research. 2015 Aug 17.
Lin MI, Price EN, Boatman S, Hagedorn EJ, Trompouki E, Satishchandran S, Carspecken CW, Uong A, DiBiase A, Yang S, Canver MC, Dahlberg A, Lu Z, Zhang CC, Orkin SH, Bernstein ID, Aster JC, White RM, Zon LI. Angiopoietin-like proteins stimulate HSPC development through interaction with Notch receptor signaling. Elife. 2015 Feb 25;4.
Kong Y, Grimaldi M, Curtin E, Dougherty M, Kaufman C, White RM, Zon LI, Liao EC. Neural Crest Development and Craniofacial Morphogenesis is Coordinated by Nitric Oxide and Histone Acetylation. Chem Biol. 2014 Apr 24;21(4):488-501.
Yen J, White RM, Wedge DC, Van Loo P, de Ridder J, Capper A, Richardson J, Jones D, Raine K, Watson IR, Wu CJ, Cheng J, Martincorena I, Nik-Zainal S, Mudie L, Moreau Y, Marshall J, Ramakrishna M, Tarpey P, Shlien A, Whitmore I, Gamble S, Latimer C, Langdon E, Kaufman C, Dovey M, Taylor A, Menzies A, McLaren S, O’Meara S, Butler A, Teague J, Lister J, Chin L, Campbell P, Adams DJ, Zon LI, Patton EE, Stemple DL, Futreal PA. The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome Biol. 2013;14(10):R113.
Paik EJ, Mahony S, White RM, Price EN, DiBiase A, Dorjsuren B, Mosimann C, Davidson A, Gifford D, Zon LI. A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis. Stem Cell Reports. 2013 Nov 7;1(5):425-36.
Storer NY, White RM, Uong A, Price E, Nielsen GP, Langenau DM, Zon LI. Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis. Development, 2013 Jul;140(14):3040-50.
Zhang L, Alt C, Li P, White RM, Zon LI, Wei X, Lin CP. An optical platform for cell tracking in adult zebrafish. Cytometry A. 2012 Feb;81(2):176-82.
Taylor AM, Humphries JM, White RM, Murphey RD, Burns CE, Zon LI. Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Exp Hematol. 2012 Mar;40(3):228-237.e5.
Li P, White RM, Zon LI. Transplantation in zebrafish. Methods Cell Biol. 2011;105:403-17.
White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, Granter S, Young RA, Morrison S, Wheeler GN, Zon LI. DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature, 2011 Mar 24; 471(7339):518-22.
Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT. T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell 2010 Oct 19;18(4):353-66.
Pugach EK, Li P, White RM, Zon L. Retro-orbital injection in adult zebrafish.
J Vis Exp. 2009 Dec 7;(34). pii: 1645.
Dovey M, White RM, Zon LI. Oncogenic NRAS Cooperates with p53 Loss to Generate Melanoma in Zebrafish. Zebrafish 2009 Dec;6(4):397-404.
Kaufman CK, White RM, Zon L. Chemical genetic screening in the zebrafish embryo.
Nat Protoc. 2009;4(10):1422-32.
Sessa AK, White RM, Houvras Y, Burke C, Pugach E, Baker B, Gilbert R, Thomas Look A, Zon LI. The effect of a depth gradient on the mating behavior, oviposition site preference, and embryo production in the zebrafish, Danio rerio. Zebrafish. 2008 Dec;5(4):335-9.
White RM, Sessa A, Burke C, Bowman T, LeBlanc J, Ceol C, Bourque C, Dovey M, Goessling W, Burns CE, Zon LI. Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell. 2008 Feb 7;2(2): 183-9.
White RM, Skarin A. Signal transduction inhibitors in the treatment of non-small cell lung cancer. Hospital Physician 8(2): 1-12, 2006.
White RM, Rivera CO, and Davison CB. Nitric oxide-dependent and independent mechanisms account for gender differences in vasodilation to acetylcholine. Journal of Pharmacology and Experimental Therapeutics 292(1):375-80, 2000.
White RM, Rivera CO, and Davison CB. Differential contribution of endothelium function to vascular reactivity in conduit and resistance arteries from DOC-salt hypertensive rats. Hypertension 27:1245-1253, 1996.
REVIEWS AND COMMENTARIES
Cagan RL, Zon LI, White RM. Modeling cancer with fish and flies. Developmental Cell, 2019 May 6;49(3):317-324.
Koelwyn GJ, Quail DF, Zhang X, White RM, Jones LW. Exercise-dependent regulation of the tumour microenvironment. Nat Rev Cancer. 2017 Sep 25;17(10):620-632.
White RM. Genomic Approaches to Zebrafish Cancer. Adv Exp Med Biol. 2016;916:125-45
White RM. Cross-species oncogenomics using zebrafish models of cancer. Curr Opin Genet Dev. 2015 Feb;30:73-9
Yen J, White RM, Stemple DL. Zebrafish models of cancer: progress and future challenges. Curr Opin Genet Dev. 2014 Feb;24:38-45.
White RM, Rose K, Zon LI. Zebrafish cancer: the state of the art and the path forward. Nat Rev Cancer. 2013 Sep;13(9):624-36.
Tamplin OJ, White RM, Jing L, Kaufman CK, Lacadie SA, Li P, Taylor AM, Zon LI. Small molecule screening in zebrafish: swimming in potential drug therapies. Wiley Interdiscip Rev Dev Biol. 2012 May-Jun;1(3):459-68.
Ceol CC, Houvras Y, White RM, Zon LI. Melanoma biology and the promise of zebrafish. Zebrafish. 2008 Dec;5(4):247-55.
White RM, Zon LI. Melanocytes in development, regeneration and cancer. Cell Stem Cell. 2008 Sep 11;3(3):242-52.