The Simon Powell Lab: Publications

Visit PubMed for a full listing of Simon N. Powell’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Bindra RS, Goglia AG, Jasin M, Powell SN. Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells. Nucleic Acids Res. 2013 Jun 1;41(11):e115. doi: 10.1093/nar/gkt255. Epub 2013 Apr 12.

Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, Deckbar D, Löbrich M, Yang Q, Khanna KK, Worman HJ, Pandita TK. Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest. Mol Cell Biol. 2013 Mar;33(6):1210-22. doi: 10.1128/MCB.01676-12. Epub 2013 Jan 14. PubMed

Chun J, Buechelmaier ES, Powell SN. Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway. Mol Cell Biol. 2013 Jan;33(2):387-95. doi: 10.1128/MCB.00465-12. Epub 2012 Nov 12. PubMed

Lok BH, Powell SN. Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement. Clin Cancer Res. 2012 Dec 1;18(23):6400-6. doi: 10.1158/1078-0432.CCR-11-3150. Epub 2012 Oct 15. Review.

Lok BH, Carley AC, Tchang B, Powell SN. RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination. Oncogene. 2012 Sep 10. doi: 10.1038/onc.2012.391. [Epub ahead of print] [PMID: 22964643].

Roy R, Chun J, Powell SN. BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer. 2011 Dec 23;12(1):68-78. doi: 10.1038/nrc3181. Review. [PMID: 22193408].

Guo GS, Zhang FM, Gao RJ, Delsite R, Feng ZH, Powell SN. DNA repair and synthetic lethality. Int J Oral Sci. 2011 Oct;3(4):176-9. doi: 10.4248/IJOS11064. Review.

Glazer PM, Grandis J, Powell SN, Brown JM, Helleday T, Bristow R, Powis G, Hill RP, Le QT, Pelroy R, Mohla S, Bernhard EJ. Radiation Resistance in Cancer Therapy: Meeting Summary and Research Opportunities Report of an NCI Workshop held September 1-3, 2010.Radiat Res. 2011 Sep;176(3):e0016-21. Epub 2011 Jul 8.

Sirbu BM, Lachmayer SJ, Wülfing V, Marten LM, Clarkson KE, Lee LW, Gheorghiu L, Zou L, Powell SN, Dahm-Daphi J, Willers H.ATR-p53 Restricts Homologous Recombination in Response to Replicative Stress but Does Not Limit DNA Interstrand Crosslink Repair in Lung Cancer Cells. PLoS One. 2011;6(8):e23053. Epub 2011 Aug 12.

Powell SN, Kachnic LA.Homologous recombination research is heating up and ready for therapy. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9731-2. Epub 2011 Jun 3.

Bott M, Brevet M, Taylor BS, Shimizu S, Ito T, Wang L, Creaney J, Lake RA, Zakowski MF, Reva B, Sander C, Delsite R, Powell S, Zhou Q, Shen R, Olshen A, Rusch V, Ladanyi M. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. Nat Genet. 2011 Jun 5;43(7):668-72.

Feng Z, Scott SP, Bussen W, Sharma GG, Guo G, Pandita TK, Powell SN. Rad52 inactivation is synthetically lethal with BRCA2 deficiency.Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):686-91. Epub 2010 Dec 8.

Barker CA, Powell SN.Enhancing radiotherapy through a greater understanding of homologous recombination. Semin Radiat Oncol. 2010 Oct;20(4):267-273.e3. Review.

Shi W, Feng Z, Zhang J, Gonzalez-Suarez I, Vanderwaal RP, Wu X, Powell SN, Roti Roti JL, Gonzalo S, Zhang J. The role of RPA2 phosphorylation in homologous recombination in response to replication arrest.Carcinogenesis. 2010 Jun;31(6):994-1002. Epub 2010 Feb 3.

Willers H, Taghian AG, Luo CM, Treszezamsky A, Sgroi DC, Powell SN.Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies.Mol Cancer Res. 2009 Aug;7(8):1304-9. Epub 2009 Aug 11.

Gupta A, Yang Q, Pandita RK, Hunt CR, Xiang T, Misri S, Zeng S, Pagan J, Jeffery J, Puc J, Kumar R, Feng Z, Powell SN, Bhat A, Yaguchi T, Wadhwa R, Kaul SC, Parsons R, Khanna KK, Pandita TK.Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.Cell Cycle. 2009 Jul 15;8(14):2198-210. Epub 2009 Jul 7.

Powell SN, Bindra RS.Targeting the DNA damage response for cancer therapy.DNA Repair (Amst). 2009 Sep 2;8(9):1153-65. Epub 2009 Jun 5. Review.

Hu X, Macdonald DM, Huettner PC, Feng Z, El Naqa IM, Schwarz JK, Mutch DG, Grigsby PW, Powell SN, Wang X.A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer.Gynecol Oncol. 2009 Sep;114(3):457-64. Epub 2009 Jun 5.

Xiang T, Ohashi A, Huang Y, Pandita TK, Ludwig T, Powell SN, Yang Q.Negative Regulation of AKT Activation by BRCA1.Cancer Res. 2008 Dec 15;68(24):10040-4.

Willers H, Kachnic LA, Luo CM, Li L, Purschke M, Borgmann K, Held KD, Powell SN.Biomarkers and mechanisms of FANCD2 function.J Biomed Biotechnol. 2008;2008:821529.

Powell SN, Kachnic LA. Therapeutic exploitation of tumor cell defects in homologous recombination. Anticancer Agents Med Chem. 2008 May;8(4):448-60.

Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow RG. Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Cancer Res. 2008 Jan 15;68(2):605-14.

Evans JW, Chernikova SB, Kachnic LA, Banath JP, Sordet O, Delahoussaye YM, Treszezamsky A, Chon BH, Feng Z, Gu Y, Wilson WR, Pommier Y, Olive PL, Powell SN, Brown JM. Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells. Cancer Res. 2008 Jan 1;68(1):257-65.

Willers H, Kachnic LA, Luo CM, Li L, Purschke M, Borgmann K, Held KD, Powell SN. Biomarkers and mechanisms of FANCD2 function. J Biomed Biotechnol. 2008;2008:821529.

Treszezamsky AD, Kachnic LA, Feng Z, Zhang J, Tokadjian C, Powell SN. BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II. Cancer Res. 2007 Aug 1;67(15):7078-81.

Willers H, Husson J, Lee LW, Hubbe P, Gazemeier F, Powell SN, Dahm-Daphi J. Distinct mechanisms of nonhomologous end joining in the repair of site-directed chromosomal breaks with noncomplementary and complementary ends. Radiat Res. 2006 Oct;166(4):567-74.

Pandita RK, Sharma GG, Laszlo A, Hopkins KM, Davey S, Chakhparonian M, Gupta A, Wellinger RJ, Zhang J, Powell SN, Roti Roti JL, Lieberman HB, Pandita TK. Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair. Mol Cell Biol. 2006 Mar;26(5):1850-64.

Zhuang J, Zhang J, Willers H, Wang H, Chung JH, van Gent DC, Hallahan DE, Powell SN, Xia F. Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining. Cancer Res. 2006 Feb 1;66(3):1401-8.

Hu B, Wang H, Wang X, Lu HR, Huang C, Powell SN, Huebner K, Wang Y. Fhit and CHK1 have opposing effects on homologous recombination repair. Cancer Res. 2005 Oct 1;65(19):8613-6.

Zhang J, Powell SN. The role of the BRCA1 tumor suppressor in DNA double-strand break repair. Mol Cancer Res. 2005 Oct;3(10):531-9. Review.

Zhang J, Ma Z, Treszezamsky A, Powell SN. MDC1 interacts with Rad51 and facilitates homologous recombination. Nat Struct Mol Biol. 2005 Oct;12(10):902-9. Epub 2005 Sep 25.

Litman R, Peng M, Jin Z, Zhang F, Zhang J, Powell S, Andreassen PR, Cantor SB. BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell. 2005 Sep;8(3):255-65.

Powell SN. The roles of BRCA1 and BRCA2 in the cellular response to ionizing radiation. Radiat Res. 2005 Jun;163(6):699-700.

Dahm-Daphi J, Hubbe P, Horvath F, El-Awady RA, Bouffard KE, Powell SN, Willers H. Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53. Oncogene. 2005 Mar 3;24(10):1663-72.

Romanova LY, Willers H, Blagosklonny MV, Powell SN. The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene. 2004 Dec 2;23(56):9025-33.

Wang H, Wang H, Powell SN, Iliakis G, Wang Y. ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining. Cancer Res. 2004 Oct 1;64(19):7139-43.

Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK. BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem. 2004 Jul 23;279(30):31251-8. Epub 2004 May 24.

Feng Z, Kachnic L, Zhang J, Powell SN, Xia F. DNA damage induces p53-dependent BRCA1 nuclear export. .J Biol Chem. 2004 Jul 2;279(27):28574-84. Epub 2004 Apr 15.

Willers H, Dahm-Daphi J, Powell SN. Repair of radiation damage to DNA. Br J Cancer. 2004 Apr 5;90(7):1297-301. Review.

Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT, Chung JH, Powell SN, Xia F. Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol. 2004 Jan;24(2):708-18.

Powell SN, Kachnic LA. Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation. Oncogene. 2003 Sep 1;22(37):5784-91. Review.

Powell SN, Willers H, Xia F. BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer? Mol Cell. 2002 Dec;10(6):1262-3.

Xia F, Powell SN. The molecular basis of radiosensitivity and chemosensitivity in the treatment of breast cancer. Semin Radiat Oncol. 2002 Oct;12(4):296-304. Review.

Willers H, Xia F, Powell SN. Recombinational DNA Repair in Cancer and Normal Cells: The Challenge of Functional Analysis. J Biomed Biotechnol. 2002;2(2):86-93.

Willers H, McCarthy EE, Hubbe P, Dahm-Daphi J, Powell SN. Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53. Carcinogenesis. 2001 Nov;22(11):1757-63.

Xia F, Taghian DG, DeFrank JS, Zeng ZC, Willers H, Iliakis G, Powell SN. Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8644-9. Epub 2001 Jul 10.

Wang H, Zeng ZC, Bui TA, DiBiase SJ, Qin W, Xia F, Powell SN, Iliakis G. Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2. Cancer Res. 2001 Jan 1;61(1):270-7.

Willers H, McCarthy EE, Alberti W, Dahm-Daphi J, Powell SN. Loss of wild-type p53 function is responsible for upregulated homologous recombination in immortal rodent fibroblasts. Int J Radiat Biol. 2000 Aug;76(8):1055-62.

Willers H, McCarthy EE, Wu B, Wunsch H, Tang W, Taghian DG, Xia F, Powell SN. Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control. Oncogene. 2000 Feb 3;19(5):632-9.

Tang W, Willers H, Powell SN. p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts. Cancer Res. 1999 Jun 1;59(11):2562-5.

Kachnic LA, Wu B, Wunsch H, Mekeel KL, DeFrank JS, Tang W, Powell SN. The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase. J Biol Chem. 1999 May 7;274(19):13111-7.

Powell SN, Mills J, McMillan TJ. Radiosensitive human tumour cell lines show misrepair of DNA termini. Br J Radiol. 1998 Nov;71(851):1178-84.

Mekeel KL, Tang W, Kachnic LA, Luo CM, DeFrank JS, Powell SN. Inactivation of p53 results in high rates of homologous recombination. Oncogene. 1997 Apr 17;14(15):1847-57.

DeFrank JS, Tang W, Powell SN. p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine. Cancer Res. 1996 Dec 1;56(23):5365-8.

Luo CM, Tang W, Mekeel KL, DeFrank JS, Anné PR, Powell SN. High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines. J Biol Chem. 1996 Feb 23;271(8):4497-503.

Powell SN, DeFrank JS, Connell P, Eogan M, Preffer F, Dombkowski D, Tang W, Friend S. Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay. Cancer Res. 1995 Apr 15;55(8):1643-8.

Powell SN, McMillan TJ. The repair fidelity of restriction enzyme-induced double strand breaks in plasmid DNA correlates with radioresistance in human tumor cell lines. Int J Radiat Oncol Biol Phys. 1994 Jul 30;29(5):1035-40.

Powell S, Whitaker S, Peacock J, McMillan T. Ataxia telangiectasia: an investigation of the repair defect in the cell line AT5BIVA by plasmid reconstitution. Mutat Res. 1993 Jun;294(1):9-20.

Powell SN, Abraham EH. The biology of radioresistance: similarities, differences and interactions with drug resistance. Cytotechnology. 1993;12(1-3):325-45. Review.

Powell SN, McMillan TJ, Steel GG. In vitro radiosensitivity of human medulloblastoma cell lines. J Neurooncol. 1993 Jan;15(1):91-2. No abstract available. Erratum in: J Neurooncol 1993 Apr;16(1):89.

Powell SN, Whitaker SJ, Edwards SM, McMillan TJ. A DNA repair defect in a radiation-sensitive clone of a human bladder carcinoma cell line. Br J Cancer. 1992 Jun;65(6):798-802.

Powell S, McMillan TJ. Clonal variation of DNA repair in a human glioma cell line. Radiother Oncol. 1991 Aug;21(4):225-32. Review.

Whitaker SJ, Powell SN, McMillan TJ. Molecular assays of radiation-induced DNA damage. Eur J Cancer. 1991;27(7):922-8. Review.

Powell S, McMillan TJ. DNA damage and repair following treatment with ionizing radiation. Radiother Oncol. 1990 Oct;19(2):95-108. Review. No abstract available.

Powell S.N., DeFrank J.S., Connell P., Eogan M., Preffer F., Dombkowski D., Tang W. and Friend S.H. Differential sensitivity of p53- and p53+ cells to caffeine-induced radiosensitization and override of G2 delay. Cancer Research 55: 1643-1648, 1995.

Romanova L., Willers H., Blagosklonny M. and Powell S.N. The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene, 2004, Dec 2;23(56):9025-33.

Xia F., Taghian D.G., McDonough K.M., DeFrank J.S., Willers H., Iliakis G., Powell S.N. Deficiency of the human BRCA2 leads to impaired homologous recombination but maintains normal non-homologous end-joining. Proceedings of the National Academy of Sciences, 2001, 98(15) 8644-9.

Zhang J., Willers H., Feng Z., Ghosh J.C., Kim S., Weaver D.T., Chung J.H., Powell S.N., Xia F. Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol. 2004 Jan 24(2):708-18.

Zhang J, Ma Z, Treszezamsky A, Powell S.N. MDC1 interacts with Rad51 and facilitates homologous recombination. Nature Struct Mol Biol. 2005 Oct; 12(10):902-9.