Our theme is vitamin A in human and animal physiology. We pursue the hypothesis that vitamin A plays essential roles in signal transduction, distinct from the function of the two principal biological derivatives of vitamin A: retinoic acid in transcription and retinaldehyde in vision. The fundamental importance of vitamin A in physiology is best exemplified in mitochondria where vitamin A is a co-regulator of energy homeostasis.
- Chiu H-J, Fishman, DA. and Hammerling U. Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation. FASEB J. 2008 Nov;22(11):3878-87.
- Acin-Perez R, Hoyos B, Zhao F, Vinogradov V, Fischman DA, Harris RA, Leitges M, Nuttaporn W, Blaner WS, Manfredi G, and Hammerling U. Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. FASEB J. 2010, 24: 627-636.