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In Brief

Gut Microbes Help Feed a Regrowing Immune System after Bone Marrow Transplant

A study conducted in mice suggests the value of healthy gut flora in people receiving a bone marrow transplant.

side-by-side bone marrow slides showing different levels of immune cell growth

In the Clinic

Single-Cell Analysis Enables Researchers to Understand the Differences within Tumors

Scientists are decoding the genetic changes that drive individual cancer cells. This may help them develop more-effective targeted therapies.

Man and woman in white lab coats looking at test tubes

In the Clinic

Chemotherapy-Immunotherapy Combination Aims to Knock Out Melanoma with a One-Two Punch

A new approach for treating melanoma combines the immunotherapy drug ipilimumab with chemotherapy that treats only the area affected by cancer.

Jedd Wolchok and Charlotte Ariyan in the lab

In the Lab

Prostate Cancer Drug Could Protect Bone Marrow from Damage Caused by Radiation

Researchers are working on a novel method for addressing a common complication of cancer treatment — bone marrow suppression.

Cross sections of mouse femurs showing bone marrow after radiation and no drug (left) and after radiation plus drug (right).

Q & A

Building a Safer Opioid: MSK Research Seeks to Develop New Ways to Relieve Pain

Science could lead to a new type of opioid drug that blocks pain but has a lower potential for addiction or abuse.

MP1104 binding to the kappa opioid receptor

Feature

How a Chicken Helped Solve the Mystery of Cancer

When this feathered patient found her way into a New York laboratory in 1909, she changed the course of cancer science.

A barred Plymouth Rock hen

Science Byte

Blocking Enzymes That Signal DNA Damage Could Be a Treatment Strategy for Childhood Cancers

A new strategy for treating pediatric cancers involves preventing cells from repairing their own DNA.

Graphic of shattered, red, DNA double-helix

Announcement

FDA Approves First CAR T Cell Therapy for Leukemia

Children, teens, and young adults with leukemia that have stopped responding to chemotherapy are the first eligible to receive the new treatment.

Pediatric oncologist Kevin Curran with CAR T patient Esmeralda Pineda

In the Lab

When Loss Is a Gain: New Tumor Suppressor Gene Identified in Follicular Lymphoma

The reason certain patients with follicular lymphoma do worse than others may come down to a missing gene.

A scientist looks at illustrations of chromosomes.