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In the Lab

Analyzing Urine Can Guide the Treatment of Childhood Kidney Tumors

A protein detected in the urine of children with Wilms’ tumor led to the development of a test to improve diagnosis and treatment.

Illustration of child with kidneys highlighted, cup of urine, and a beam of light.

Finding

Sugar Directly Controls a Cancer-Causing Protein, Scientists Find

The discovery suggests a potential new treatment approach for certain cancers.

An illustration of sugar pouring onto NRF2

In the Lab

Scientists Develop a Tool to Watch a Single Gene Being Transcribed in a Living Cell

A new imaging technology developed at MSK allows researchers to focus on genes as they are copied into messenger RNA.

Molecular image with target symbol

In the Lab

Drug That Hits CAR T Snooze Button Can Quiet a Cytokine Storm

An FDA-approved drug used to treat leukemia can serve as a temporary off switch for CAR T cells, MSK scientists have found.

cartoon of man hitting a snooze button

In the Lab

Scientists Use CRISPR to Learn How Cells Make Decisions

The genome-editing technique uncovered several genes previously not known to influence embryonic development.

Fluorescent red and green cells

In the Lab

Research Clarifies How IDH Mutations Cause Cancer

The MSK team’s goal was to get at the underlying defects in cells that these mutations cause.

DNA winding around histones

In the Lab

Stem Cells Stay “Young” on a Fat-Free Diet

Researchers have discovered a simple way to keep stem cells in a more flexible state for research and potential treatments.

 Colored scanning electron micrograph of a clump of pluripotent stem cells.

In The Lab

Ro Versus Musashi: How One Molecule Can Turn Cancer Cells Back to Normal

Researchers identify a compound that appears to eliminate tumor cells in a dish and in mice.

An illustration of a samurai and a crab.

In the Lab

Checkpoint Challenge: When Releasing Immune Cell Brakes Is Not Enough to Stop Cancer

Scientists have learned that cutting a T cell’s brakes can have unexpected consequences.

Immune cells surrounding a cancer cell

In The Lab

Computational “Hive Mind” Helps Scientists Solve an Enzyme’s Cryptic Movements

The breakthrough gives an unprecedented look at the varied and shifting poses of a protein in action.

Two clusters of colored blobs with a diagram in the middle