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391 News Items found
Finding
Systems biologist Joao Xavier in his lab
MSK Study Is the First to Link Microbiota to Dynamics of the Human Immune System

MSK researchers have shown for the first time that the concentration of different types of immune cells in the blood changes in relation to the presence of different bacterial strains in the gut.
In the Lab
SKI cell biologists Junmei Yi and Xuejun Jiang
More Evidence that Cellular ‘Death by Iron’ Could Be Promising Avenue of Cancer Treatment

Cancers with certain mutations are vulnerable to ferroptosis, a form of iron-dependent cell death.
In the Lab
An illustration of a reel of film
Feature Presentation: 3D Movies of Cell Signaling in Early Development from the Hadjantonakis Lab

Grab your popcorn and pull up a chair for these video shorts of cell signaling in early mouse development.
In the Lab
MSK immunologist Ming Li.
MSK-led Studies Support the Concept of “Cancer Environment Immunotherapy”

Targeting the cancer environment, rather than the cancer itself, could be a new avenue for immunotherapy.
Q&A
MSK developmental biologist Lorenz Studer
Taking Aim at Parkinson’s Disease: A Conversation with Developmental Biologist Lorenz Studer

In an interview in September 2020, Dr. Studer spoke about what he hopes he and his fellow investigators can accomplish with this generous support.
Regulatory proteins (gold balls) bind to enhancer regions (light blue) and promoter regions (pink) of DNA to form clusters that enable transcription (purple).
Going the Distance: How DNA Enhancers Communicate with Their Target Genes

Scientists at the Sloan Kettering Institute are learning how far-flung regions of genes connect to start the process of making proteins.
Article
An illustration of a beta-amyloid plaque among the neurons in a brain.
MSK Study Links Inflammation to Alzheimer’s Disease Development

An enzyme that contributes to plaque formation in the brain also serves as a first line of defense against bacteria and viruses, suggesting a link between the two.
In the Lab
Black blobs on a white background
Separation Anxiety: Cell Division Gone Awry Leads to Genetic Chaos

Researchers shed light on how aberrant cell division can cause the kind of mutations often found in cancer cells.
MSK molecular geneticist Elli Papaemmanuil.
Large International Study Pinpoints Impact of TP53 Gene Mutations on Blood Cancer Severity

Having two mutated copies of the TP53 gene — as opposed to a single mutated copy — is associated with worse outcomes in a blood cancer called myelodysplastic syndrome, according to a new study led by researchers at Memorial Sloan Kettering.
Finding
Section of a lung cancer tumor in mice
A Never-Before-Seen Cell State May Explain Cancer’s Ability to Resist Drugs

Identified in mice, this unusual cell state emerges early during tumor evolution and gives tumors enormous malleability.