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In The Lab

Ro Versus Musashi: How One Molecule Can Turn Cancer Cells Back to Normal

By Julie Grisham

Researchers identify a compound that appears to eliminate tumor cells in a dish and in mice.

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An illustration of a samurai and a crab.

In the Lab

Checkpoint Challenge: When Releasing Immune Cell Brakes Is Not Enough to Stop Cancer

By Matthew Tontonoz

Scientists have learned that cutting a T cell’s brakes can have unexpected consequences.

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Immune cells surrounding a cancer cell

In The Lab

Computational “Hive Mind” Helps Scientists Solve an Enzyme’s Cryptic Movements

By Matthew Tontonoz

The breakthrough gives an unprecedented look at the varied and shifting poses of a protein in action.

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Two clusters of colored blobs with a diagram in the middle

Q & A

Steering Cancer Cells Back to Normal: 8 Questions with Kristian Helin

By Matthew Tontonoz

Learn about Kristian Helin, the new Chair of the Cell Biology Program at the Sloan Kettering Institute and Director of the Center for Epigenetics Research at MSK.

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Kristian Helin in his laboratory

Feature

How Do Immune Cells Kill Their Prey?

By Matthew Tontonoz

When an immune cell faces a foe, it has more than chemical weapons at its disposal.

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An illustration of an immune cell killing a cancer cell, and a snake attacking a mouse

In The Lab

Scientists Home In On “Equation” for Muscle Cell Size

By Matthew Tontonoz

A new study in flies reveals a previously unknown type of cooperation at work in muscle cells.

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Mutlinucleated muscle cells from flies

Feature

Beyond Sugar: What Cancer Cells Need to Grow

By Matthew Tontonoz

While sugar gets most of the attention as a cancer fuel, other nutrients can be equally important.

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a cartoon of a cancer cell spooning glutamine from a jar

Science Byte

Scientists Discover Keys to Immune Response against Anthrax

By Jim Stallard

Researchers clarify how the immune system activates an inflammatory defense against pathogens.

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Ribbon diagram of an anthrax protein.

In the Lab

Scientists Rewrite the Textbook of Organ Development, One Cell at a Time

By Matthew Tontonoz

A large study that analyzed nearly 120,000 cells in a developing mouse embryo is full of surprises.

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In this fluorescent microscopy image of endoderm tissue from a mouse embryo, cell membranes are red, cell nuclei are blue, and extra-embryonic endoderm cells are green (they appear turquoise because blue and green are merged).

Feature

An Old Protein Gets a New Look: Researchers Target TGF-ß to Make Immunotherapy More Effective

By Julie Grisham

Drugs that block the action of TGF-ß may make checkpoint inhibitors more effective.

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Model of TGF-beta molecule