2023 Postdoctoral Awardees
Lingling Cheng, PhD
Project Title: “Integrating high-throughput single-molecule imaging and forward genetics for un-biased discovery of novel regulators of enhancer-promoter communication and dissection of complex multi-enhancer regulatory landscapes”
Enhancers enable precise spatiotemporal gene expression, by activating target promoters over large genomic distances. The specific factors that facilitate enhancer-promoter communication, as well as how multiple enhancers in complex regulatory landscapes work together to control transcription are key issues that remain unaddressed. The goal of this project is to close these knowledge gaps by developing new discovery platforms based on high-throughput single-molecule imaging and CRISPR forward genetics screens.
Michael Geeson, PhD
Project Title: “A simple technology to monitor intracellular redox potential”
Cells are constantly working to maintain a redox state that is out of equilibrium with their surroundings. Disruption of this redox potential causes changes to important cellular processes, and can even result in cell death. We are developing a sensor that allows us to quickly and accurately measure the redox state of a cell, enabling researchers to understand how cellular redox state responds to a diverse range of stimuli and environments
2022 Postdoctoral Awardee
Meret Arter, PhD
Project Title: “Combining novel structure- and function-informed phylogenetic analyses with molecular approaches to investigate the extraordinary plasticity of the meiotic recombination machinery”
To generate haploid gametes during meiosis most sexually reproducing organisms use the homologous recombination DNA repair pathway. While this process of meiotic recombination is almost universally conserved across eukaryotes, the protein machinery required for it is surprisingly variable between species. The goal of this project is to better understand the evolutionary forces that have shaped and keep shaping the meiotic recombination machinery and experimentally address the functional relevance of this remarkable variation
2021 Postdoctoral Awardee
Benjamin Winer, PhD
Project Title: “Defining how cells make decisions between migration and phagocytosis”
Neutrophils are the most abundant immune cell type and play an important role in detecting infection and disease. Neutrophils and other granulocytes must make complex decisions about where to move within the body and whether to perform phagocytosis, a process where they engulf and degrade a diseased cell or pathogen. The relationship between migration and phagocytosis is not well understood. The purpose of this project is to gain insight into these processes.
2020 Postdoctoral Awardees
Alberto Muñoz, PhD
Project Title: “Development of A One-Pot Synthesis of Carbonyl (Bio)isosteres”
The overall goal of this project is to develop new methods in organic synthesis that provide rapid access to complex and understudied pharmacophores. Our proposed methodologies promise to be catalytic, mild, and user friendly, requiring only visible light in the presence of a photosensitive catalyst to achieve a powerful molecular transformation. The compounds generated throughout the course of our studies will be implemented in research programs geared toward improving human health.
Keunwoo Ryu, PhD
Project Title: “Functional Segregation of Mitochondria by High-Order Assembly of Metabolic Enzymes”
Mitochondria are highly dynamic and play a vital role in bioenergetic and biosynthetic pathways. However, how mitochondria maintain the intricate balance between biosynthetic and bioenergetic functions, especially those that utilize shared substrates and cofactors, remains poorly understood. The proposed research aims to explore whether mitochondria can functionally segregate into distinct populations that independently maintain biosynthetic and bioenergetic functions.
2019 BRIF Awardees
Project Title: Development and application of a cysteine reactivity-based drug discovery platform for challenging protein targets
Project Title: CRISPRa-based Single Cell Barcoding for Tracking and Recovery of Rare Drug Resistant Persister Populations