2020 Postdoctoral Awardees
Alberto Muñoz, PhD
Project Title: “Development of A One-Pot Synthesis of Carbonyl (Bio)isosteres”
The overall goal of this project is to develop new methods in organic synthesis that provide rapid access to complex and understudied pharmacophores. Our proposed methodologies promise to be catalytic, mild, and user friendly, requiring only visible light in the presence of a photosensitive catalyst to achieve a powerful molecular transformation. The compounds generated throughout the course of our studies will be implemented in research programs geared toward improving human health.
Keunwoo Ryu, PhD
Project Title: “Functional Segregation of Mitochondria by High-Order Assembly of Metabolic Enzymes”
Mitochondria are highly dynamic and play a vital role in bioenergetic and biosynthetic pathways. However, how mitochondria maintain the intricate balance between biosynthetic and bioenergetic functions, especially those that utilize shared substrates and cofactors, remains poorly understood. The proposed research aims to explore whether mitochondria can functionally segregate into distinct populations that independently maintain biosynthetic and bioenergetic functions.
2019 BRIF Awardees
Project Title: Development and application of a cysteine reactivity-based drug discovery platform for challenging protein targets
Project Title: CRISPRa-based Single Cell Barcoding for Tracking and Recovery of Rare Drug Resistant Persister Populations