Basic Research Innovation Scholars Fellowship Publications
Arter M, Keeney S. Divergence and conservation of the meiotic recombination machinery. Nat Rev Genet. 2024 May;25(5):309-325. doi: 10.1038/s41576-023-00669-8. Epub 2023 Nov 30. PMID: 38036793.
Geeson MB, Hsiao JC, Tsamouri LP, Ball DP, Bachovchin DA. The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond. Cell Chem Biol. 2024 May 16;31(5):955-961.e4. doi: 10.1016/j.chembiol.2023.12.012. Epub 2024 Jan 11. PMID: 38215746; PMCID: PMC11102328.
Ryu KW, Fung TS, Baker DC, et al. Cellular ATP demand creates metabolically distinct subpopulations of mitochondria. Nature. 2024 Nov;635(8039):746-754. doi: 10.1038/s41586-024-08146-w. Epub 2024 Nov 6. PMID: 39506109.
Zhu J, Schwörer S, Berisa M, Kyung YJ, Ryu KW, Yi J, Jiang X, Cross JR, Thompson CB. Mitochondrial NADP(H) generation is essential for proline biosynthesis. Science. 2021 May 28;372(6545):968-972. doi: 10.1126/science.abd5491. Epub 2021 Apr 22. PMID: 33888598; PMCID: PMC8241437.
Winer BY, Settle AH, Yakimov AM, Jeronimo C, Lazarov T, Tipping M, Saoi M, Sawh A, Sepp AL, Galiano M, Perry JSA, Wong YY, Geissmann F, Cross J, Zhou T, Kam LC, Pasolli HA, Hohl T, Cyster JG, Weiner OD, Huse M. Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells. Sci Immunol. 2024 Jun 7;9(96):eadl2388. doi: 10.1126/sciimmunol.adl2388. Epub 2024 Jun 7. PMID: 38848343; PMCID: PMC11485225.
Settle AH, Winer BY, de Jesus MM, Seeman L, Wang Z, Chan E, Romin Y, Li Z, Miele MM, Hendrickson RC, Vorselen D, Perry JSA, Huse M. β2 integrins impose a mechanical checkpoint on macrophage phagocytosis. Nat Commun. 2024 Sep 18;15(1):8182. doi: 10.1038/s41467-024-52453-9. PMID: 39294148; PMCID: PMC11411054.
Liu D, Winer BY, Chou MY, Tam H, Xu Y, An J, Gardner JM, Cyster JG. Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function. Nat Immunol. 2024 Jan;25(1):142-154. doi: 10.1038/s41590-023-01690-z. Epub 2023 Dec 4. PMID: 38049580; PMCID: PMC10761324.
Sanchez EE, Tello-Lafoz M, Guo AJ, de Jesus M, Elbanna YA, Winer BY, Budhu S, Chan E, Rosiek E, Kondo T, DuSold J, Taylor N, Altan-Bonnet G, Olson MF, Huse M. Apoptotic contraction drives target cell release by cytotoxic T cells. Nat Immunol. 2023 Sep;24(9):1434-1442. doi: https://doi.org/10.1038/s41590-023-01572-4. Epub 2023 Jul 27. PMID: 37500886; PMCID: PMC11138163.
Full Project Publications
Claeys Bouuaert C, Pu S, Wang J, Oger C, Daccache D, Xie W, Patel DJ, Keeney S. DNA-driven condensation assembles the meiotic DNA break machinery. Nature. 2021 Apr;592(7852):144-149. doi: 10.1038/s41586-021-03374-w. Epub 2021 Mar 17. PMID: 33731927; PMCID: PMC8016751.
Liu K, Grasso EM, Pu S, Zou M, Liu S, Eliezer D, Keeney S. Structure and DNA-bridging activity of the essential Rec114-Mei4 trimer interface. Genes Dev. 2023 Jun 1;37(11-12):518-534. doi: 10.1101/gad.350461.123. Epub 2023 Jul 13. PMID: 37442580; PMCID: PMC10393192.
Xu J, Li T, Kim S, Boekhout M, Keeney S. Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2310951120. doi: 10.1073/pnas.2310951120. Epub 2023 Nov 17. PMID: 37976262; PMCID: PMC10666023.
Yu Y, Wang J, Liu K, Zheng Z, Arter M, Bouuaert CC, Pu S, Patel DJ, Keeney S. Cryo-EM structure of the Spo11 core complex bound to DNA. bioRxiv [Preprint]. 2023 Nov 1:2023.10.31.564985. doi: 10.1101/2023.10.31.564985. Update in: Nat Struct Mol Biol. 2024 Sep 20. doi: 10.1101/2023.10.31.564985. PMID: 37961437; PMCID: PMC10634984.
Cryo-EM structures of G4-stalled CMG reveal inchworm mechanism of DNA translocation Sahil Batra, Benjamin Allwein, Charanya Kumar, Sujan Devbhandari, Jan-Gert Bruning, Soon Bahng, Chong Lee, Kenneth J. Marians, Richard K. Hite, Dirk Remus bioRxiv 2024.10.02.616340; doi: https://doi.org/10.1101/2024.10.02.616340
Delos Reyes, A. M. V.; Nieves Escobar, C. S.; Muñoz, A.; Huffman, M. I.; Tan, D. S.* “Direct conversion of amino acids to oxetanol bioisosteres via photoredox catalysis.” Chem. Sci. 2023, 14, 10524–10531. DOI: 10.1039/d3sc00936j. PMID: 37734424 PMCID: PMC10548506
Chromatin architecture mapping by multiplex proximity tagging Axel Delamarre, Benton Bailey, Jennifer Yavid, Richard Koche, Neeman Mohibullah, Iestyn Whitehouse bioRxiv 2024.11.12.623258; doi: https://doi.org/10.1101/2024.11.12.623258
Li S, Yu Y, Zheng J, Miller-Browne V, Ser Z, Kuang H, Patel DJ, Zhao X. Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions. Proc Natl Acad Sci U S A. 2023 Nov 7;120(45):e2310924120. doi: 10.1073/pnas.2310924120. Epub 2023 Oct 30. PMID: 37903273; PMCID: PMC10636319.
Li Q, Zhang J, Haluska C, Zhang X, Wang L, Liu G, Wang Z, Jin D, Cheng T, Wang H, Tian Y, Wang X, Sun L, Zhao X, Chen Z, Wang L. Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat Struct Mol Biol. 2024 Oct;31(10):1532-1542. doi: 10.1038/s41594-024-01319-1. Epub 2024 Jun 18. PMID: 38890552; PMCID: PMC11479838.