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The Łuksza Lab develops predictive models of immune-driven evolution to understand how tumors and viruses adapt under immune pressure.

… The Łuksza Lab develops predictive models of immune-driven evolution to understand how tumors and viruses adapt under immune pressure. By integrating concepts from information theory, machine learning, statistical physics, and quantitative immunology, the lab builds computational frameworks to quantify

The Long laboratory investigates the molecular mechanisms of ion channels and enzymatic membrane proteins and seeks to use these discoveries to benefit humanity.

… Our laboratory uses a combination of structural biology and biophysical techniques to discover how ion channels and membrane-embedded enzymes function at the atomic level. The proteins we study are crucial for the function of the immune system, vision, cell differentiation, and embryonic development,

Physician-scientist Luke R.G. Pike studies the mechanistic underpinnings of brain metastasis and seeks to identify translational correlates with outcomes following local or systemic therapy.

… The Luke Pike Lab seeks to understand the unique biology of brain metastasis (BrM) and to improve outcomes for patients afflicted with this terrible disease. BrM is an exceptionally common form of solid tumor metastasis, affecting approximately 400,000 U.S. cancer patients each year. The mechanisms by

Molecular pathologist Marc Ladanyi studies the molecular pathogenesis of sarcomas, lung cancer, and mesothelioma.

… The research program in this laboratory focuses on the genomics and molecular pathogenesis of sarcomas and thoracic malignancies, with an emphasis on clinical translation of potential diagnostic markers and therapeutic targets. Dr. Ladanyi also co-directs (with Chris Sander) the Genome Data Analysis

The Lito lab investigates the properties of oncoproteins that drive cancer cell growth, with a focus on cancers driven by RAS mutations.

… The Lito lab investigates the properties of oncoproteins that drive cancer cell growth, with a focus on cancers driven by RAS mutations. RAS mutants were historically thought to be locked in an active state due to an inability to break down the nucleotide GTP. Contrary to this long-held view, we discovered

Led by Dr. Irene Orlow, the Lab participates in self-initiated research and supports investigations from the Population Sciences & Clinical Research programs that involving human specimens processing, testing, and banking. For additional information on current research, publications, and presentations by the Lab, and more, scroll down and click on the ‘View Lab Overview’ or ‘Current Projects’ links.

…   The Molecular Epidemiology Laboratory Led by Dr. Irene Orlow, the Lab participates in self-initiated research and supports investigations from the Population Sciences & Clinical Research programs that involve handling and testing human specimens. For additional information on current research, publications

The Lareau Lab synthesizes computational and experimental genomics methods to study how immune cells in our bodies adapt, expand, differentiate, and evolve over an individual’s lifetime.

… The focus of the Lareau Lab is to understand how cells in our bodies adapt, expand, and evolve during the course of our lives, particularly in the immune system. The theme of our lab’s research is Computational and Translational Immunology, which is purposefully broad but grounds our research program

Derek Tan’s lab studies diversity-oriented synthesis and rational drug design of probes and lead compounds for chemical biology and drug discovery.

… The identification of small-molecule probes and therapeutic lead compounds to address novel biological targets is a significant current challenge in chemical biology and drug discovery. We are engaged in a two-pronged approach to this problem involving diversity-oriented synthesis and rational design

Alban Ordureau explores molecular signaling pathways that regulate cellular homeostasis, with a focus on the ubiquitin and autophagy systems.

… My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end, we combine cell biological, genome engineering (CRISPR), and biochemical approaches to provide new

The Minn Lab investigates how cancers evolve under chronic inflammation and persistent immune pressure to acquire resistance to immunotherapies, with the goal of developing innovative therapies to restore anti-tumor immunity.

… In the Minn Lab, we interrogate the intersection of chronic inflammation and interferon signalling, virus mimicry pathways, and immune checkpoint resistance in tumor cells — integrating cellular, molecular and translational approaches. Our goal is to convert mechanistic insights into new therapeutic