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New roles for Notch signaling in the immune system.

… Dr. Maillard’s research focuses on the role of Notch signaling in hematopoiesis as well as in T and B cell development, differentiation and function. Through more than 15 years of research in the field, his laboratory discovered essential functions for Notch receptors and ligands in graft-versus-host

The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.

… We apply both precision gene editing and large-scale CRISPR screening in human pluripotent stem cells (hPSCs) to explore mechanisms underlying human development. Specifically, we are interrogating the protein-coding regulators of pancreatic development and β cell function. The pathways that regulate

Cancer biologist Nikolaus Schultz uses computational tools to study the diversity of genomic alterations underlying different cancer types.

… The Schultz lab focuses on identifying the genomic alterations that underlie different types of cancer. By applying existing and novel computational methods to large scale cancer genomics data sets, the lab aims to better understand the complex mechanisms at the gene and at the pathway level that drive

Molecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.

… The major theme of our work is how DNA repair processes are disrupted in human cancers and how this can be exploited therapeutically.   Join the Powell Lab! Simon N. Powell, MD, PhD Enid A. Haupt Chair in Radiation Oncology Professor PhD, MD, University of London Email [email protected] Laboratory phone

The Hite laboratory studies the mechanisms of ion and metabolite transport and the maintenance of genomic integrity.

… Our research group has two primary focuses. One part of the lab focuses on determining the mechanisms of intracellular ion and metabolite transport, while the second studies protein nucleic acid interactions that are critical for maintaining genomic integrity. We study these fundamental processes using

The Łuksza Lab develops predictive models of immune-driven evolution to understand how tumors and viruses adapt under immune pressure.

… The Łuksza Lab develops predictive models of immune-driven evolution to understand how tumors and viruses adapt under immune pressure. By integrating concepts from information theory, machine learning, statistical physics, and quantitative immunology, the lab builds computational frameworks to quantify

My research is focused on cellular and molecular mechanisms that control the differentiation, maintenance, and physiological functions of macrophages and monocytes and their roles in tissue homeostasis and disease processes.

… Over the past ten years, we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in diverse types of cancer and can either restrain or promote cancer progression and metastasis. The Geissmann

The Hadjantonakis laboratory studies pluripotency and cell fate specification, tissue patterning and morphogenesis, in mammalian embryos and stem cell-derived embryo models.

… Cancer is a condition arising when cells undergo an identity crisis.  Understanding of how cells control their identity, and how they assemble into tissues with normal organization and function during embryonic development provides the essential blueprint for gaining insights into the fundamental biological

Derek Tan’s lab studies diversity-oriented synthesis and rational drug design of probes and lead compounds for chemical biology and drug discovery.

… The identification of small-molecule probes and therapeutic lead compounds to address novel biological targets is a significant current challenge in chemical biology and drug discovery. We are engaged in a two-pronged approach to this problem involving diversity-oriented synthesis and rational design

Alban Ordureau explores molecular signaling pathways that regulate cellular homeostasis, with a focus on the ubiquitin and autophagy systems.

… My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end, we combine cell biological, genome engineering (CRISPR), and biochemical approaches to provide new