Most guidelines recommend annual PSA testing for men starting at age 50. Men at increased risk for prostate cancer may begin annual PSA testing earlier. A prostate biopsy, which is performed by a urologist, is usually recommended for men who have a rising or abnormally high PSA, says surgical oncologist Vincent Laudone of Memorial Sloan Kettering Cancer Center. Biopsy results such as PIN (prostatic intraepithelial neoplasia) and ASAP (atypical small acinar proliferation) may indicate cancer. PSA (prostate-specific antigen) tests may be performed after surgery to see if any prostate cancer cells remain in the body.