I have a strong clinical interest in combining surgery, systemic chemotherapy, and hepatic arterial infusional chemotherapy (chemotherapy delivered directly to the liver through an implanted device) to treat tumors that have spread extensively throughout the liver. I have developed minimally invasive (laparoscopic) approaches to liver surgery as well pancreatic resections.
I also care for many patients with primary liver cancer and have numerous treatment options for these patients including liver resection, hepatic artery embolization, and hepatic artery infusional chemotherapy.
In addition to my clinical work, I am very involved in research. I have published extensively on the treatment of metastatic colorectal cancer and proven that cure is possible with liver resection. I have been very involved in research on treatments for gallbladder, pancreas, and bile duct cancer. I have developed clinical trials to determine the effectiveness of the combination of surgery and hepatic arterial infusional chemotherapy for unresectable liver metastases. Finally members of my research group are studying tissues from our surgical specimens to identify genetic changes in tumors. This will help us better understand treatment outcomes and enable us to develop new treatments.