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Clinical Expertise
Soft Tissue Sarcomas: Liposarcoma, Gastrointestinal Stromal Tumor, Synovial Sarcoma, Leiomyosarcoma, Malignant Peripheral Nerve Sheath Tumor, Angiosarcoma, Fibrosarcoma, Desmoid Tumor, Dermatofibrosarcoma, MFH, Myxofibrosarcoma, Rhabdomyosarcoma, Ewing’s Sarcoma, Extremity Sarcoma, and Retroperitoneal Sarcoma
Languages Spoken
English
Education
MD, Harvard Medical School
Residencies
Brigham and Women’s Hospital/Harvard Medical School
Fellowships
Dana-Farber Cancer Institute
Board Certifications
Surgery
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Publications by Samuel Singer
Visit PubMed for full listing of Samuel Singer journal articles
Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.
angiosarcoma (AN-jee-oh-sar-KOH-muh)
A type of cancer that begins in the cells that line blood vessels or lymph vessels. Cancer that begins in blood vessels is called hemangiosarcoma. Cancer that begins in lymph vessels is called lymphangiosarcoma.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
cancer (KAN-ser)
A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
cell (sel)
The individual unit that makes up the tissues of the body. All living things are made up of one or more cells.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
chemotherapy (KEE-moh-THAYR-uh-pee)
Treatment with drugs that kill cancer cells.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
clinical (KLIH-nih-kul)
Having to do with the examination and treatment of patients.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
desmoid tumor (DEZ-moyd TOO-mer)
A tumor of the tissue that surrounds muscles, usually in the abdomen. A desmoid tumor rarely metastasizes (spreads to other parts of the body). It may be called aggressive fibromatosis when the tumor is outside of the abdomen.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
diagnosis (DY-ug-NOH-sis)
The process of identifying a disease, such as cancer, from its signs and symptoms.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
DNA
The molecules inside cells that carry genetic information and pass it from one generation to the next. Also called deoxyribonucleic acid.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
extremity (ek-STREH-mih-tee)
A limb of the body, such as the arm or leg.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
fibrosarcoma (FY-broh-sar-KOH-muh)
A type of soft tissue sarcoma that begins in fibrous tissue, which holds bones, muscles, and other organs in place.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
gastrointestinal (GAS-troh-in-TES-tih-nul)
Refers to the stomach and intestines. Also called GI.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
gastrointestinal stromal tumor (GAS-troh-in-TES-tih-nul STROH-mul TOO-mer)
A type of tumor that usually begins in cells in the wall of the gastrointestinal tract. It can be benign or malignant. Also called GIST.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
HDAC
An enzyme that removes a small molecule called an acetyl group from histones (proteins found in chromosomes). This changes the way the histones bind to DNA and may affect its activity. HDAC inhibitors are being studied in the treatment of cancer. Also called histone deacetylase.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
kinase (KY-nays)
A type of enzyme that causes other molecules in the cell to become active. Some kinases work by adding chemicals called phosphates to other molecules, such as sugars or proteins. Kinases are a part of many cell processes. Some cancer treatments target certain kinases that are linked to cancer.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
leiomyosarcoma (LY-oh-MY-oh-sar-KOH-muh)
A malignant (cancer) tumor of smooth muscle cells that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
liposarcoma (LIH-poh-sar-KOH-muh)
A rare cancer of the fat cells.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
malignant (muh-LIG-nunt)
Cancerous. Malignant cells can invade and destroy nearby tissue and spread to other parts of the body.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
medicine (MEH-dih-sin)
Refers to the practices and procedures used for the prevention, treatment, or relief of symptoms of a diseases or abnormal conditions. This term may also refer to a legal drug used for the same purpose.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
multidisciplinary (MUL-tee-DIH-sih-plih-NAYR-ee)
In medicine, a term used to describe a treatment planning approach or team that includes a number of doctors and other health care professionals who are experts in different specialties (disciplines). In cancer treatment, the primary disciplines are medical oncology (treatment with drugs), surgical oncology (treatment with surgery), and radiation oncology (treatment with radiation).
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
multimodality treatment (MUL-tee-moh-DA-lih-tee TREET-ment)
Therapy that combines more than one method of treatment. Also called combination therapy and multimodality therapy.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
National Institutes of Health (NA-shuh-nul IN-stih-TOOTS … helth)
A federal agency in the U.S. that conducts biomedical research in its own laboratories; supports the research of non-Federal scientists in universities, medical schools, hospitals, and research institutions throughout the country and abroad; helps in the training of research investigators; and fosters communication of medical information. Access the National Institutes of Health Web site at . Also called NIH.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
nerve (nerv)
A bundle of fibers that receives and sends messages between the body and the brain. The messages are sent by chemical and electrical changes in the cells that make up the nerves.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
oncologist (on-KAH-loh-jist)
A doctor who specializes in treating cancer. Some oncologists specialize in a particular type of cancer treatment. For example, a radiation oncologist specializes in treating cancer with radiation.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
outcome (OWT-kum)
A specific result or effect that can be measured. Examples of outcomes include decreased pain, reduced tumor size, and improvement of disease.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
quality of life (KWAH-lih-tee ... life)
The overall enjoyment of life. Many clinical trials assess the effects of cancer and its treatment on the quality of life. These studies measure aspects of an individual’s sense of well-being and ability to carry out various activities.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
radiation (RAY-dee-AY-shun)
Energy released in the form of particle or electromagnetic waves. Common sources of radiation include radon gas, cosmic rays from outer space, medical x-rays, and energy given off by a radioisotope (unstable form of a chemical element that releases radiation as it breaks down and becomes more stable).
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
retroperitoneal (REH-troh-PAYR-ih-toh-NEE-ul)
Having to do with the area outside or behind the peritoneum (the tissue that lines the abdominal wall and covers most of the organs in the abdomen).
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
rhabdomyosarcoma (RAB-doh-MY-oh-sar-KOH-muh)
Cancer that forms in the soft tissues in a type of muscle called striated muscle. Rhabdomyosarcoma can occur anywhere in the body.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
RNA
One of two types of nucleic acid made by cells. RNA contains information that has been copied from DNA (the other type of nucleic acid). Cells make several different forms of RNA, and each form has a specific job in the cell. Many forms of RNA have functions related to making proteins. RNA is also the genetic material of some viruses instead of DNA. RNA can be made in the laboratory and used in research studies. Also called ribonucleic acid.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
sarcoma (sar-KOH-muh)
A cancer of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
soft tissue (... TIH-shoo)
Refers to muscle, fat, fibrous tissue, blood vessels, or other supporting tissue of the body.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
soft tissue sarcoma (…TIH-shoo sar-KOH-muh)
A cancer that begins in the muscle, fat, fibrous tissue, blood vessels, or other supporting tissue of the body.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
surgery (SER-juh-ree)
A procedure to remove or repair a part of the body or to find out whether disease is present. An operation.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
synovial sarcoma (sih-NOH-vee-ul sar-KOH-muh)
A malignant tumor that develops in the synovial membrane of the joints.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
targeted therapy (TAR-geh-ted THAYR-uh-pee)
A type of treatment that uses drugs or other substances, such as monoclonal antibodies, to identify and attack specific cancer cells. Targeted therapy may have fewer side effects than other types of cancer treatments.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
therapy (THAYR-uh-pee)
Treatment.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
tissue (TIH-shoo)
A group or layer of cells that work together to perform a specific function.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
tumor (TOO-mer)
An abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Tumors may be benign (not cancer), or malignant (cancer). Also called neoplasm.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
WHO
A part of the United Nations that deals with major health issues around the world. The WHO sets standards for disease control, health care, and medicines; conducts education and research programs; and publishes scientific papers and reports. A major goal is to improve access to health care for people in developing countries and in groups who do not get good health care. The headquarters are located in Geneva, Switzerland. Also called World Health Organization.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
will (wil)
A legal document in which a person states what is to be done with his or her property after death, who is to carry out the terms of the will, and who is to care for any minor children.
Source: The National Cancer Institute's Dictionary of Cancer Terms(http://www.cancer.gov/dictionary)
View Samuel Singer's laboratory research.
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