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Clinical Summary

Acupuncture, an important component of Traditional Chinese Medicine (TCM), originated more than 2,000 years ago. Treatment involves stimulation of one or more predetermined points on the body with needles, heat (moxibustion), pressure (acupressure), or electricity for therapeutic effect.

Acupuncture is beneficial for osteoarthritis of the knee (1) (2) (3), chronic mechanical neck pain (4), and symptoms associated with fibromyalgia (5). It was also superior to physical therapy (6) in treating patients with low back pain compared with usual care (7) (8) and was cost effective (9). Acupuncture also reduced high blood pressure (10)and the severity of hot flashes in postmenopausal women (11) , but had mixed results for treating major depressive disorder (12) (13). In addition, studies show benefits of acupuncture for peripheral neuropathy (14) , including that associated with diabetes (15), AIDS (16) (17), and chemotherapy (18) (19). Data from clinical trials support use of acupuncture for chronic headache (20) (21) (22), but there was no difference between true and sham acupuncture; the treatments were, however, more effective compared with a no acupuncture control (23).

Acupuncture also improved reproductive outcomes in women following in vitro fertilization, but clinical studies yielded conflicting results (24) (25) (26) (27) (28); acupuncture did not have an analgesic effect in women undergoing induced labor (29). Acupuncture treatments reduced symptoms of chronic prostatitis/chronic pelvic pain (30), and decreased procedural anxiety in patients undergoing lithotripsy (31). Data from a study done in children undergoing endoscopic procedures indicate benefits of acupressure in reducing preprocedural anxiety (32). Acupuncture may also benefit patients with allergic rhinitis when used in conjunction with standard care, and was cost effective (33) (34).

Acupuncture is being used in the palliative care of cancer to alleviate pain (35) (36), dysfunction (36), and chronic fatigue (37), to reduce post-operative (38) and chemotherapy-induced (39) (40) (41) (42) nausea and vomiting, and to ameliorate xerostomia or dry mouth, commonly experienced by cancer patients following radiotherapy of the head and neck regions (36) (43) (44). Findings from a randomized trial suggest that it is as effective as standard care for the management of hot flashes in breast cancer patients (45). Acupuncture also alleviated aromatase inhibitor-induced joint pain and stiffness, improving physical well-being in patients with breast cancer (46).

Acupuncture is generally safe and well tolerated by patients including children (47) (48) (49). Some conditions require continuous treatments in order to achieve long-term effect. Pregnant women, patients with lymphedema, those wearing pacemakers, and those with low platelet count should inform their practitioners before receiving treatment. Cancer patients considering acupuncture should seek certified or state-licensed practitioners who have training or experience in working with cancer patients.

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Purported Uses
  • Chemotherapy side effects
  • Radiation therapy side effects
  • Nausea and vomiting
  • Pain
  • Constipation
  • Depression
  • Fatigue
  • Allergy
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Mechanism of Action

According to TCM, acupuncture points are thought to be located at specific areas along channels or meridians. Qi (energy) is believed to flow in this network of channels which connect different parts of the body and organs into a unified system. Pain and symptoms of disease are thought to arise when the flow of Qi is stagnated and acupuncture is intended to promote the flow of Qi to relieve symptoms. Acupuncture is known to stimulate release of endogenous opioids. Needles inserted in one part of the body can affect pain sensation in another region (56). Scientific studies have demonstrated that acupuncture can induce analgesia, but that effect was blocked by naloxone, an opioid antagonist (50) (51). Further, mice lacking opiate receptors showed low analgesic effect following electroacupuncture (EA) (52). Recent research shows that EA inhibits pain through different opioid receptors under varying conditions, but the mechanisms warrant further investigation (53). EA was shown to increase ovarian blood flow via ovarian sympathetic nerves in rats (54), and protected against cerebral ischemia by increasing blood flow to the ischemic brain region via neural regulation (55).
Studies using functional magnetic resonance imaging (fMRI) have shown that acupuncture elicits changes in the brain that appear to correlate with neurological effects produced (57). Needling of LI-2, one of several acupoints used to treat xerostomia, is associated with neuroimaging changes correlated to saliva production (58). Results from a study done in patients with peripheral neuropathy indicate that acupuncture improves nerve conduction (14).
Acupuncture also increases neuropetite Y in animals suggesting it has benefits in reducing stress and depression (59) (60).

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Contraindications
  • Neutropenia, thrombocytopenia, or history of endocarditis
    Acupuncture may increase risk of infection and bleeding. Use with caution.
  • Pregnancy
    Pregnant women should inform practitioners before seeking acupuncture treatment.
  • Pacemakers
    Electrical stimulation is contraindicated for patients wearing electronic medical devices.
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Adverse Reactions

Acupuncture is generally safe when performed by trained practitioners. Studies in Europe and Japan showed that less than 0.2% of all individuals treated with acupuncture experienced adverse effects. Failure to remove needles, bleeding, hematoma, dizziness, and pain are the commonly reported adverse events. Pneumothorax, local infections, and burns caused by moxibustion are rare.

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Literature Summary and Critique

Meng Z, Garcia MK, Hu C, et al. Randomized controlled trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma. Cancer. 2011 Nov 9. doi: 10.1002/cncr.26550. [Epub ahead of print]
A total of 86 patients with nasopharyngeal carcinoma were randomized to receive acupuncture (AC) or standard of care to prevent xerostomia. Patients were treated 3 times per week before radiotherapy, and both subjective measures (a xerostomia questionnaire [XQ] and MD Anderson Symptom Inventory–Head and Neck [MDASI-HN]) and objective measures (salivary flow rates) were obtained for up to 6 months of followup. XQ was significantly lower for AC than controls starting week 3 through 6 months with clinically significant differences at week 11; findings for MDASI-HN scores were similar. Group differences emerged as early as 3 weeks into treatment for saliva with greater saliva flow in the AC group at weeks 7 and 11 and at 6 months. AC given concurrently with radiotherapy significantly reduced xerostomia and improved quality of life. Other trials are ongoing.

Andreescu C, Glick RM, Emeremni CA, et al. Acupuncture for the treatment of major depressive disorder: a randomized controlled trial. J Clin Psychiatry. 2011;72:1129-35. Epub 2011 May 3.
Fifty-three patients with mild or moderate major depressive disorder were randomized to acupuncture or sham control for a total of twelve 30-minute sessions (twice per week) over 6 to 8 weeks and evaluated using the Hamilton Depression Rating Scale (HDRS) as the primary outcome measure. Both treatments resulted in similar absolute and relative improvements using HDRS and significant decreases in HDRS sleep and anxiety subscale scores from baseline to end of intervention. No adverse effects were reported with either intervention. More studies in MDD populations are needed.

Brinkhaus B, Witt CM, Jena S, et al. Acupuncture in patients with allergic rhinitis: a pragmatic randomized trial. Ann Allergy Asthma Immunol. 2008;101:535-543.
This study involved patients with allergic rhinitis, 487 of whom were assigned to receive up to 15 acupuncture treatments over 3 months, 494 patients to a control group, and 4,256 patients to a nonrandomized acupuncture group. All patients were being treated with standard care for rhinitis. Researchers found that at 3 months, those receiving acupuncture had greater improvement in quality of life compared with patients in the control group as assessed by the Rhinitis Quality of Life Questionnaire. The 6-month improvements in the acupuncture groups were smaller compared with the 3-month assessment. These data indicate that acupuncture resulted in clinically relevant and persistent benefits, and can be a useful adjunct with routine care in the management of allergic rhinitis.

Walker EM, Rodriguez AI, Kohn B, et al. Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: A randomized controlled trial. J Clin Oncol. 2009;28 [Epub ahead of print].
In this study, 50 breast cancer patients were randomly assigned to receive 12 weeks of acupuncture or venlafaxine, the standard drug therapy used to address hot flashes. Following the study period, both groups reported significant reduction in hot flashes, depressive symptoms, and improvement in energy levels, clarity of thought and a sense of well-being. But two weeks after treatment, patients in the venlafaxine group experienced significant increases in hot flashes compared with those in the acupuncture group. The venlafaxine group also reported 18 incidences of adverse effects such as nausea, dry mouth, dizziness, and anxiety. No such effects were seen in the acupuncture group. Acupuncture may be a safe and effective alternative to drug therapy for reducing hot flashes in breast cancer patients.

Vickers AJ, et al. Acupuncture for postchemotherapy fatigue: A phase II study. J Clin Oncol. 2004;22:1731-1735.
In this study involving cancer patients who had completed chemotherapy but experienced persistent fatigue, 25 patients received acupuncture twice a week for 4 weeks and 12 patients received acupuncture once a week for 6 weeks. Patients reported an improvement of 31% in fatigue level measured at 2 weeks after the final treatment compared with baseline. There was no significant difference in weekly and bi-weekly treatments. The result suggests that acupuncture has benefit in treating postchemotherapy fatigue. However, this is only a preliminary study on a small number of patients and was not randomized. Further studies involving large number of patients are warranted.

Vickers AJ, et al. Acupuncture for chronic headache in primary care: large, pragmatic, randomized trial. BMJ. 2004;328:744-749.
In this study, 401 patients with chronic headache were randomly assigned to receive up to 12 acupuncture treatments over a period of 3 months or conventional treatment. Patients in the acupuncture group reported fewer headaches, less use of medication, fewer visits to doctors, and improved quality of life compared with those who received conventional care. Researchers concluded that acupuncture offers persistent clinical benefits for patients with chronic headache, particularly migraine.

Alimi D, et al. Analgesic effect of auricular acupuncture for cancer pain: A randomized, blinded, controlled trial. J Clin Oncol. 2003;21:4120-4126.
Ninety cancer patients were randomly assigned to receive two courses of true auricular acupuncture; auricular acupuncture at placebo points; or with auricular seeds fixed at placebo points. At a 2-month assessment, patients who received acupuncture reported a 36% decrease in pain from baseline compared with 2% in those who received placebo. Researchers concluded that acupuncture significantly reduced pain in cancer patients who were in pain despite being treated with analgesics.

Shen J, et al. Electroacupuncture for control of myeloablative chemotherapy-induced emesis. A randomized controlled trial. JAMA. 2000;284:2755-2761.
In this study, 104 breast cancer patients undergoing chemotherapy were randomly assigned to receive EA at antiemetic acupuncture points once daily for 5 days; minimal needling at control points with mock stimulation once daily for 5 days; or antiemetic drugs alone. All the patients received the same chemotherapeutic and antiemetic drugs. At the end of 5 days, patients who received EA reported fewer episodes of vomiting compared with those who received minimal needling or antiemetic drugs alone. However, these effects were not observed at a follow-up done from days 6-14. Researchers concluded that EA was effective in the short-term for controlling emesis associated with chemotherapeutic treatment in breast cancer patients.

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References
  1. Berman BM, Lao L, Langenberg P, et al. Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial. Ann Intern Med. Dec 21 2004;141(12):901-910.
  2. Scharf HP, Mansmann U, Streitberger K, et al. Acupuncture and knee osteoarthritis: a three-armed randomized trial. Ann Intern Med. Jul 4 2006;145(1):12-20.
  3. Witt CM, Jena S, Brinkhaus B, et al. Acupuncture in patients with osteoarthritis of the knee or hip: a randomized, controlled trial with an additional nonrandomized arm. Arthritis Rheum. Nov 2006;54(11):3485-3493.
  4. White P, Lewith G, Prescott P, et al. Acupuncture versus placebo for the treatment of chronic mechanical neck pain: a randomized, controlled trial. Ann Intern Med. Dec 21 2004;141(12):911-919.
  5. Martin DP, Sletten CD, Williams BA, et al. Improvement in fibromyalgia symptoms with acupuncture: results of a randomized controlled trial. Mayo Clin Proc. Jun 2006;81(6):749-757.
  6. Hsieh LL, Kuo CH, Lee LH, et al. Treatment of low back pain by acupressure and physical therapy: randomised controlled trial. BMJ. Mar 25 2006;332(7543):696-700.
  7. Thomas KJ, MacPherson H, Thorpe L, et al. Randomised controlled trial of a short course of traditional acupuncture compared with usual care for persistent non-specific low back pain. BMJ. Sep 23 2006;333(7569):623.
  8. Haake M, Muller HH, Schade-Brittinger C, et al. German Acupuncture Trials (GERAC) for chronic low back pain: randomized, multicenter, blinded, parallel-group trial with 3 groups. Arch Intern Med. Sep 24 2007;167(17):1892-1898.
  9. Ratcliffe J, Thomas KJ, MacPherson H, et al. A randomised controlled trial of acupuncture care for persistent low back pain: cost effectiveness analysis. BMJ. Sep 23 2006;333(7569):626.
  10. Flachskampf FA, Gallasch J, Gefeller O, et al. Randomized trial of acupuncture to lower blood pressure. Circulation. Jun 19 2007;115(24):3121-3129.
  11. Huang MI, Nir Y, Chen B, et al. A randomized controlled pilot study of acupuncture for postmenopausal hot flashes: effect on nocturnal hot flashes and sleep quality. Fertil Steril. Sep 2006;86(3):700-710.
  12. Allen JJ, Schnyer RN, Chambers AS, et al. Acupuncture for depression: a randomized controlled trial. J Clin Psychiatry. Nov 2006;67(11):1665-1673.
  13. Andreescu C, Glick RM, Emeremni CA, et al. Acupuncture for the treatment of major depressive disorder: a randomized controlled trial. J Clin Psychiatry. Aug 2011;72(8):1129-1135.
  14. Schroder S, Liepert J, Remppis A, et al. Acupuncture treatment improves nerve conduction in peripheral neuropathy. Eur J Neurol. Mar 2007;14(3):276-281.
  15. Ahn AC, Bennani T, Freeman R, et al. Two styles of acupuncture for treating painful diabetic neuropathy—a pilot randomised control trial. Acupunct Med. Jun 2007;25(1-2):11-17.
  16. Shlay JC, Chaloner K, Max MB, et al. Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS. JAMA. Nov 11 1998;280(18):1590-1595.
  17. Phillips KD, Skelton WD, Hand GA. Effect of acupuncture administered in a group setting on pain and subjective peripheral neuropathy in persons with human immunodeficiency virus disease. J Altern Complement Med. Jun 2004;10(3):449-455.
  18. Xu WR, Hua BJ, Hou W, et al. [Clinical randomized controlled study on acupuncture for treatment of peripheral neuropathy induced by chemotherapeutic drugs]. Zhongguo Zhen Jiu. Jun 2010;30(6):457-460.
  19. Donald GK, Tobin I, Stringer J. Evaluation of acupuncture in the management of chemotherapy-induced peripheral neuropathy. Acupunct Med. Sep 2011;29(3):230-233.
  20. Vickers AJ, Rees RW, Zollman CE, et al. Acupuncture for chronic headache in primary care: large, pragmatic, randomised trial. BMJ. Mar 27 2004;328(7442):744.
  21. Xue CC, Dong L, Polus B, et al. Electroacupuncture for tension-type headache on distal acupoints only: a randomized, controlled, crossover trial. Headache. Apr 2004;44(4):333-341.
  22. Coeytaux RR, Kaufman JS, Kaptchuk TJ, et al. A randomized, controlled trial of acupuncture for chronic daily headache. Headache. Oct 2005;45(9):1113-1123.
  23. Linde K, Streng A, Jurgens S, et al. Acupuncture for patients with migraine: a randomized controlled trial. JAMA. May 4 2005;293(17):2118-2125.
  24. Westergaard LG, Mao Q, Krogslund M, et al. Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial. Fertil Steril. May 2006;85(5):1341-1346.
  25. Dieterle S, Ying G, Hatzmann W, et al. Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection: a randomized, prospective, controlled clinical study. Fertil Steril. May 2006;85(5):1347-1351.
  26. Smith C, Coyle M, Norman RJ. Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer. Fertil Steril. May 2006;85(5):1352-1358.
  27. Manheimer E, Zhang G, Udoff L, et al. Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis. BMJ. Mar 8 2008;336(7643):545-549.
  28. Moy I, Milad MP, Barnes R, et al. Randomized controlled trial: effects of acupuncture on pregnancy rates in women undergoing in vitro fertilization. Fertil Steril. Feb 2011;95(2):583-587.
  29. Mackenzie IZ, Xu J, Cusick C, et al. Acupuncture for pain relief during induced labour in nulliparae: a randomised controlled study. BJOG. Mar 2011;118(4):440-447.
  30. Lee SW, Liong ML, Yuen KH, et al. Acupuncture versus sham acupuncture for chronic prostatitis/chronic pelvic pain. Am J Med. Jan 2008;121(1):79 e71-77.
  31. Wang SM, Punjala M, Weiss D, et al. Acupuncture as an adjunct for sedation during lithotripsy. J Altern Complement Med. Mar 2007;13(2):241-246.
  32. Wang SM, Escalera S, Lin EC, et al. Extra-1 acupressure for children undergoing anesthesia. Anesth Analg. Sep 2008;107(3):811-816.
  33. Brinkhaus B, Witt CM, Jena S, et al. Acupuncture in patients with allergic rhinitis: a pragmatic randomized trial. Ann Allergy Asthma Immunol. Nov 2008;101(5):535-543.
  34. Witt CM, Reinhold T, Jena S, et al. Cost-effectiveness of acupuncture in women and men with allergic rhinitis: a randomized controlled study in usual care. Am J Epidemiol. Mar 1 2009;169(5):562-571.
  35. Alimi D, Rubino C, Pichard-Leandri E, et al. Analgesic effect of auricular acupuncture for cancer pain: a randomized, blinded, controlled trial. J Clin Oncol. Nov 15 2003;21(22):4120-4126.
  36. Pfister DG, Cassileth BR, Deng GE, et al. Acupuncture for pain and dysfunction after neck dissection: results of a randomized controlled trial. J Clin Oncol. May 20 2010;28(15):2565-2570.
  37. Vickers AJ, Straus DJ, Fearon B, et al. Acupuncture for postchemotherapy fatigue: a phase II study. J Clin Oncol. May 1 2004;22(9):1731-1735.
  38. Gan TJ, Jiao KR, Zenn M, et al. A randomized controlled comparison of electro-acupoint stimulation or ondansetron versus placebo for the prevention of postoperative nausea and vomiting. Anesth Analg. Oct 2004;99(4):1070-1075.
  39. Shen J, Wenger N, Glaspy J, et al. Electroacupuncture for control of myeloablative chemotherapy-induced emesis: A randomized controlled trial. JAMA. Dec 6 2000;284(21):2755-2761.
  40. Shin YH, Kim TI, Shin MS, et al. Effect of acupressure on nausea and vomiting during chemotherapy cycle for Korean postoperative stomach cancer patients. Cancer Nurs. Jul-Aug 2004;27(4):267-274.
  41. Ezzo J, Vickers A, Richardson MA, et al. Acupuncture-point stimulation for chemotherapy-induced nausea and vomiting. J Clin Oncol. Oct 1 2005;23(28):7188-7198.
  42. Molassiotis A, Helin AM, Dabbour R, et al. The effects of P6 acupressure in the prophylaxis of chemotherapy-related nausea and vomiting in breast cancer patients. Complement Th r Med. Mar 2007;15(1):3-12.
  43. Meng Z, Garcia MK, Hu C, et al. Randomized controlled trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma. Cancer. Nov 9 2011.
  44. Garcia MK, Chiang JS, Cohen L, et al. Acupuncture for radiation-induced xerostomia in patients with cancer: a pilot study. Head Neck. Oct 2009;31(10):1360-1368.
  45. Walker EM, Rodriguez AI, Kohn B, et al. Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: a randomized controlled trial. J Clin Oncol. Feb 1 2010;28(4):634-640.
  46. Crew KD, Capodice JL, Greenlee H, et al. Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer. J Clin Oncol. Mar 1 2010;28(7):1154-1160.
  47. Ng DK, Chow PY, Ming SP, et al. A double-blind, randomized, placebo-controlled trial of acupuncture for the treatment of childhood persistent allergic rhinitis. Pediatrics. Nov 2004;114(5):1242-1247.
  48. Broide E, Pintov S, Portnoy S, et al. Effectiveness of acupuncture for treatment of childhood constipation. Dig Dis Sci. Jun 2001;46(6):1270-1275.
  49. Adams D, Cheng F, Jou H, et al. The Safety of Pediatric Acupuncture: A Systematic Review. Pediatrics. Nov 21 2011.
  50. Pomeranz B, Chiu D. Naloxone blockade of acupuncture analgesia: endorphin implicated. Life Sci. Dec 1 1976;19(11):1757-1762.
  51. Pomeranz B, Warma N. Electroacupuncture suppression of a nociceptive reflex is potentiated by two repeated electroacupuncture treatments: the first opioid effect potentiates a second non-opioid effect. Brain Res. Jun 14 1988;452(1-2):232-236.
  52. Peets JM, Pomeranz B. CXBK mice deficient in opiate receptors show poor electroacupuncture analgesia. Nature. Jun 22 1978;273(5664):675-676.
  53. Meng X, Zhang Y, Li A, et al. The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy. Brain Res. Sep 26 2011;1414:58-65.
  54. Stener-Victorin E, Kobayashi R, Watanabe O, et al. Effect of electro-acupuncture stimulation of different frequencies and intensities on ovarian blood flow in anaesthetized rats with steroid-induced polycystic ovaries. Reprod Biol Endocrinol. Mar 26 2004;2:16.
  55. Zhou F, Guo J, Cheng J, et al. Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: Dependence on stimulation intensity and frequency. J Appl Physiol. Aug 11 2011.
  56. Baldry PE. Acupuncture, trigger points and musculoskeletal pain, 2nd ed. London, UK: Churchill Livingstone; 1993.
  57. Yoo SS, Teh EK, Blinder RA, et al. Modulation of cerebellar activities by acupuncture stimulation: evidence from fMRI study. Neuroimage. Jun 2004;22(2):932-940.
  58. Deng G, Hou BL, Holodny AI, et al. Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study. BMC Complement Altern Med. 2008;8:37.
  59. Eshkevari L, Egan R, Phillips D, et al. Acupuncture at ST36 prevents chronic stress-induced increases in neuropeptide Y in rat. Exp Biol Med. 2012 Jan 1;237(1):18-23. Epub 2011 Dec 7.
  60. Lim S, Ryu YH, Kim ST, et al. Acupuncture increases neuropeptide Y expression in hippocampus of maternally-separated rats. Neurosci Lett. 2003 May 29;343(1):49-52.
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How It Works


Bottom Line: Acupuncture is effective in treating some symptoms associated with cancer treatment.Acupuncture is a component of Traditional Chinese Medicine and involves use of needles, heat (moxibustion), pressure (acupressure) or electricity to stimulate one or more points in the body to promote the flow of Qi (internal energy). The World Health Organization supports the use of acupuncture in reducing symptoms, such as depression, facial pain, headache, peripheral neuropathy, lower back pain, nausea and vomiting, neck pain, postoperative pain, shortness of breath, chronic fatigue, hot flashes and side effects caused by radiotherapy and/or chemotherapy. Acupunture also reduced symptoms of sneezing, itching, and runny nose in children with allergies, and may be useful against allergic rhinitis in adults when used along with standard medications. Acupuncture also improved pregnancy rates in women following in vitro fertilization, but did not provide pain relief in women undergoing induced labor.
Acupuncture treatments are generally safe and well tolerated by most patients. Some conditions may require continuous treatments in order to achieve long-term effect.
Cancer patients considering acupuncture should seek certified or state-licensed practitioners who have training or experience in working with cancer patients.

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Purported Uses
  • Pain
    Several clinical trials showed that acupuncture is effective in alleviating pain.
  • In vitro fertilization
    Some studies show acupuncture can improve the pregnancy rates in women following in vitro fertilization. But a recent study shows no benefits.
  • Depression
    Evidence from clinical trials is inconclusive. More studies are needed.
  • Headache
    This use is supported by clinical trials.
  • Fatigue
    Several clinical trials showed that acupuncture reduces fatigue.
  • Constipation
    This use is supported by scientific evidence.
  • Nausea
    A number of studies support the use of acupuncture in treating nausea.
  • Cancer-related symptoms
    Several clinical trials support the use of acupuncture in relieving pain, nausea and vomiting, fatigue, and hot flashes resulting from cancer treatments.
  • Allergy
    A few studies have shown that acupuncture is useful in treating allergic rhinitis when used along with standard care.
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Research Evidence

Cancer
Fifty breast cancer patients were randomly assigned to receive 12 weeks of acupuncture or venlafaxine, the standard drug therapy used for the treatment of hot flashes. Following the study period, both groups reported significant reduction in hot flashes, depressive symptoms, and improvement in energy levels, clarity of thought and a sense of well-being.
But two weeks after treatment, patients in the venlafaxine group experienced significant increases in hot flashes compared to those in the acupuncture group. The venlafaxine group also reported 18 incidences of adverse effects such as nausea, dry mouth, dizziness, and anxiety. No such effects were seen in the acupuncture group.
Acupunture may be a safe and effective alternative to drug therapy for reducing hot flashes in breast cancer patients.

In a recent clinical trial, 104 breast cancer patients undergoing chemotherapy received electroacupuncture, at antiemetic acupuncture points, minimal needling at control points, or antiemetic drugs alone. Patients who received electroacupuncture reported fewer episodes of vomiting compared to those in the other groups. However, this effect was short-term and not observed at a follow-up done from days 6-14.

In another study, twenty-five cancer patients who had completed chemotherapy but experienced fatigue received acupuncture treatments twice a week for 4 weeks or once a week for 6 weeks. All patients irrespective of weekly or biweekly treatments reported a 31% improvement in fatigue level after 2 weeks following the final treatment. However, more studies involving large number of patients are needed to establish this use.

Headache
In a study conducted to determine the effects of acupuncture on headache, 401 patients with chronic headache received up to 12 acupuncture treatments over 3 months or conventional treatment. Patients in the acupuncture group had fewer headaches, paid fewer visits to doctors, and their quality of life improved compared to those in the conventional care group. Researchers concluded that acupuncture is beneficial in patients suffering from chronic headache, particularly, migraine.

Allergic rhinitis
This study involved patients with allergic rhinitis, 487 of whom were assigned to receive up to 15 acupuncture treatments over 3 months, 494 patients to a control group, and 4,256 patients to a nonrandomized acupuncture group. All patients were being treated with standard care for rhinitis. Researchers found that at 3 months, those receiving acupuncture had greater improvement in quality of life compared to patients in the control group as assessed by the Rhinitis Quality of Life Questionnaire. The six-month improvements in the acupuncture groups were smaller compared to the 3-month assessment. These data indicate that acupuncture resulted in clinically relevant and persistent benefits, and can be a useful adjunct with routine care in the management of allergic rhinitis.

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Do Not Take If

Acupuncture is not recommended
 

  • If you have low white blood cell count, low platelet count or heart murmur (symptom of endocarditis). Acupuncture may increase risk of infection and bleeding.
  • If you are pregnant (some acupuncture points can cause strong uterine contractions. Pregnant women should inform practitioners before seeking acupuncture treatment)
  • If you wear pacemakers (electrical stimulation is contraindicated for patients wearing electronic medical devices)
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Side Effects
  • Bleeding
  • Hematoma
  • Dizziness
  • Pain
  • Local infections
  • Burns (from moxibustion)
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Dosage (Inside MSKCC Only)
This field is only visible to only Inside MSKCC users.
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Aliases
Acupressure
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E-mail your questions and comments to aboutherbs@mskcc.org.
Last updated: February 1, 2012